公开(公告)号：US09675708B2

公开(公告)日：2017-06-13

申请号：US14353280

申请日：2012-10-22

申请人： STEMGENICS, INC

发明人： Andranik Andrew Aprikyan ,  Kilian Dill

IPC分类号： A61K47/48 ,  A61K38/02 ,  B60R22/34 ,  B60R22/28

CPC分类号： B60R22/3413 ,  A61K38/02 ,  A61K38/1709 ,  A61K47/6939 ,  B60R2022/286 ,  B60R2022/289 ,  B82Y5/00 ,  G01N33/54353

摘要： Functionalized biocompatible nanoparticles capable of penetrating through a mammalian cell membrane and delivering intracellularly a plurality of bioactive molecules for modulating a cellular function are disclosed herein The functionalized biocompatible nanoparticles comprise: a central nanoparticle ranging in size from about 5 to about 50 nm and having a polymer coating thereon, a plurality of functional groups covalently attached to the polymer coating, wherein the plurality of bioactive molecules are attached to the plurality of the functional groups, and wherein the plurality of bioactive molecules include at least a peptide and a protein, and wherein the peptide is capable of penetrating through the mammalian cell membrane and entering into the cell, and wherein the protein is capable of providing a new functionality within the cell. The protein may be a transcription factor selected from the group consisting of Oct4, Sox2, Nanog, Lin28, cMyc, and Klf4.

公开(公告)号：US20130140390A1

公开(公告)日：2013-06-06

申请号：US13655219

申请日：2012-10-18

申请人： TK Holdings Inc.

发明人： Gary Lee STROIK, JR.

IPC分类号： B60R22/28 ,  B60R22/34

CPC分类号： A61K47/6931 ,  A61K38/02 ,  A61K38/1709 ,  A61K47/6939 ,  B60R22/3413 ,  B60R2022/286 ,  B60R2022/289 ,  B82Y5/00 ,  G01N33/54353

摘要： A retractor assembly comprising a spool configured to wind and unwind the webbing, a lock base, and an energy absorbing member having a first end operatively connected to the locking base and a second end operatively connected to the spool. The energy absorbing member provides a progressive level of load resistance upon relative rotation between the spool and the locking base.

摘要翻译： 一种卷收器组件，包括构造成卷绕和展开织带的卷轴，锁定底座和能量吸收构件，其具有可操作地连接到锁定底座的第一端和可操作地连接到卷轴的第二端。 能量吸收构件在卷轴和锁定基座之间的相对旋转时提供渐进级的负载阻力。

公开(公告)号：US20100243782A1

公开(公告)日：2010-09-30

申请号：US12729539

申请日：2010-03-23

申请人： Joachim Biller ,  Nizam Bedak ,  Frank Hufschmied

发明人： Joachim Biller ,  Nizam Bedak ,  Frank Hufschmied

IPC分类号： B60R22/34 ,  B60R22/36 ,  B60R22/46

CPC分类号： B60R22/4676 ,  B60R2022/288 ,  B60R2022/289 ,  B60R2022/468

摘要： A belt retractor (10) comprises a belt reel (12), an adaptive belt limiter (20) and a belt tensioner (22). The force limiter (20) is arranged between the belt reel (12) and the belt tensioner (22) and is operated with a high characteristic during tensioning.

摘要翻译： 带卷收器（10）包括带卷轴（12），自适应带限制器（20）和带张紧器（22）。 力限制器（20）布置在带卷轴（12）和带张紧器（22）之间，并且在张紧期间以高特性运行。

公开(公告)号：US5295714A

公开(公告)日：1994-03-22

申请号：US970762

申请日：1992-11-03

申请人： Artur Fohl

发明人： Artur Fohl

IPC分类号： B60R22/46 ,  B60R22/195 ,  B60R22/28 ,  B60R22/36

CPC分类号： B60R22/1953 ,  B60R22/1951 ,  B60R22/28 ,  B60R2022/289

摘要： In a vehicle safety belt system a gripping means (16) is arranged at a webbing section (10) extending between a deflection fitting (12) and the belt retractor (14). In the rest condition the webbing is led freely between the oppositely disposed clamping elements of the gripping means (16). The gripping means (16) is connected via a pulling cable (38) to a pyrotechnic or mechanical belt tightener drive. Return blocking means are formed by a cylinder (44) attached to the vehicle bodywork and a piston (42) displaceable therein, whereby the cylinder wall is deformed plastically for absorbing load peaks.

摘要翻译： 在车辆安全带系统中，夹持装置（16）布置在在偏转配件（12）和带卷收器（14）之间延伸的织带部分（10）。 在静止状态下，织带在夹持装置（16）的相对设置的夹紧元件之间自由地引导。 夹持装置（16）经由拉绳（38）连接到烟火或机械带紧固器驱动器。 返回阻挡装置由附接到车辆车体的气缸（44）和可在其中移动的活塞（42）形成，由此气缸壁塑性变形以吸收载荷峰值。

公开(公告)号：US4978139A

公开(公告)日：1990-12-18

申请号：US452586

申请日：1989-12-19

申请人： Rudolf Andres ,  Heinz Knoll ,  Harald Pfistner ,  Voker Petri

发明人： Rudolf Andres ,  Heinz Knoll ,  Harald Pfistner ,  Voker Petri

IPC分类号： B60R22/28

CPC分类号： B60R22/28 ,  B60R2022/288 ,  B60R2022/289

摘要： In an energy absorbing damping device for safety belts of motor vehicles, for the purpose of controlled reduction of the deceleration force which acts on the belt user in the event of a collision, a strip element, which is connected to the safety belt, is pulled out of a coil and, by plastically deformed deformation members arranged on both sides of the strip element. The deformation members are formed as two toothed rollers, which engage with one another, so that the strip element, as it is pulled out of the coil, is first deformed sectionally and subsequently pulled straight again.

摘要翻译： 在用于机动车辆的安全带的能量吸收阻尼装置中，为了控制减少在碰撞时作用在皮带使用者上的减速力，牵引连接到安全带的带状元件被拉动 并且通过设置在带状元件的两侧上的塑性变形变形构件。 变形构件形成为彼此接合的两个齿形滚子，使得带状元件首先从线圈拉出，然后首先变形并随后再次直线拉直。

公开(公告)号：US20190241153A1

公开(公告)日：2019-08-08

申请号：US16188909

申请日：2018-11-13

申请人： Hyundai Motor Company ,  Kia Motors Corporation

发明人： Kum-Lim CHOI ,  Hyung-Moo Lee ,  Eun-Suk Suh ,  In-Ju Lee ,  Jong-Ho Kwon

IPC分类号： B60R22/28

CPC分类号： B60R22/28 ,  B60R2022/286 ,  B60R2022/289 ,  F16F7/12

摘要： A load limiter may include a load limiter body to which a downward pulling force and an upward pulling force are applied together in opposite directions, wherein the load limiter absorbs energy by deformation to limit the downward pulling force in a multi-stage manner and simultaneously absorbs energy by deformation to limit the upward pulling force in a multi-stage manner.

公开(公告)号：US20170088095A1

公开(公告)日：2017-03-30

申请号：US15124943

申请日：2015-02-23

申请人： TAKATA CORPORATION

发明人： Hayato UCHIBORI ,  Daichi NEMOTO

IPC分类号： B60R22/34 ,  B60R22/28 ,  B60R22/24

CPC分类号： B60R22/3413 ,  B60R22/24 ,  B60R22/28 ,  B60R2022/285 ,  B60R2022/289 ,  F16D7/044

摘要： To provide an energy absorbing device, a seat belt retractor, and a seat belt apparatus that can vary an energy absorbing amount depending on increase and decrease of rotation speed between relatively rotating objects and can improve durability. An energy absorbing device includes a casing connected to one object, an annular first clutch disc disposed in the casing, an annular second clutch disc disposed in the casing, and an annular clutch plate connected to the other object and having an engaging surface that faces both the first clutch disc and the second clutch disc, wherein the engaging outer teeth of the first clutch disc and the engaging inner teeth of the second clutch disc alternately engage with the engaging teeth of the clutch plate so as to absorb an energy generated by a relative rotation between one object and the other object.

公开(公告)号：US20170088093A1

公开(公告)日：2017-03-30

申请号：US15124964

申请日：2015-02-23

申请人： TAKATA CORPORATION

发明人： Hayato UCHIBORI ,  Daichi NEMOTO

IPC分类号： B60R22/28 ,  B60R22/26 ,  B60R22/34

CPC分类号： B60R22/28 ,  B60R22/26 ,  B60R22/3413 ,  B60R2022/285 ,  B60R2022/288 ,  B60R2022/289

摘要： To provide an energy absorption apparatus, a seatbelt retractor, and a seatbelt apparatus that are capable of changing the energy absorption amount according to increases and decreases in the rotation speed between objects that rotate relative to each other and capable of improving endurance. The energy absorption apparatus includes a first plate connected to one of the objects and having a wave-shaped groove formed in an annular shape, a second plate connected to another one of the objects, disposed so as to be adjacent to the first plate, and having a plurality of radial grooves formed at locations that face the wave-shaped groove, a plurality of driving pins that are inserted, at one end, in the wave-shaped groove and inserted, at another end, in the radial grooves, and a plurality of follower bodies that are housed in the wave-shaped groove or the radial grooves and that slide along the wave-shaped groove as the driving pins move.

公开(公告)号：US20140342004A1

公开(公告)日：2014-11-20

申请号：US14353280

申请日：2012-10-22

申请人： STEMGENICS, INC.

发明人： Andranik Andrew Aprikyan ,  Kilian Dill

IPC分类号： A61K47/48 ,  A61K38/02

CPC分类号： B60R22/3413 ,  A61K38/02 ,  A61K38/1709 ,  A61K47/6939 ,  B60R2022/286 ,  B60R2022/289 ,  B82Y5/00 ,  G01N33/54353

摘要： Functionalized biocompatible nanoparticles capable of penetrating through a mammalian cell membrane and delivering intracellularly a plurality of bioactive molecules for modulating a cellular function are disclosed herein The functionalized biocompatible nanoparticles comprise: a central nanoparticle ranging in size from about 5 to about 50 nm and having a polymer coating thereon, a plurality of functional groups covalently attached to the polymer coating, wherein the plurality of bioactive molecules are attached to the plurality of the functional groups, and wherein the plurality of bioactive molecules include at least a peptide and a protein, and wherein the peptide is capable of penetrating through the mammalian cell membrane and entering into the cell, and wherein the protein is capable of providing a new functionality within the cell. The protein may be a transcription factor selected from the group consisting of Oct4, Sox2, Nanog, Lin28, cMyc, and Klf4.

摘要翻译： 能够穿透哺乳动物细胞膜并递送细胞内多个生物活性分子以调节细胞功能的官能化的生物相容性纳米粒子在本文中公开。官能化的生物相容性纳米颗粒包括：尺寸为约5至约50nm的中心纳米颗粒，并且具有聚合物 在其上涂覆多个共价连接到聚合物涂层的官能团，其中多个生物活性分子连接到多个官能团，并且其中多个生物活性分子至少包括肽和蛋白质，并且其中 肽能够穿透哺乳动物细胞膜并进入细胞，并且其中蛋白质能够在细胞内提供新的功能。 蛋白质可以是选自Oct4，Sox2，Nanog，Lin28，cMyc和Klf4的转录因子。

公开(公告)号：US20130126657A1

公开(公告)日：2013-05-23

申请号：US13679466

申请日：2012-11-16

申请人： TK Holdings Inc.

发明人： Gary Lee STROIK, JR.

IPC分类号： B60R22/34

CPC分类号： B60R22/3413 ,  B60R2022/289

摘要： A retractor assembly for a seatbelt system having a webbing for restraining a secured occupant, the retractor comprising a spool configured to wind and unwind the webbing about an axis of rotation, the spool includes a side with an opening therein; a collar including an outer surface and an inner surface, the outer surface configured to engage the opening; a locking base configured to operatively engage the inner surface; and an energy absorbing member configured to provide a progressive level of load resistance upon relative rotation between the spool and the locking base.

摘要翻译： 一种用于安全带系统的卷收器组件，其具有用于限制安全乘客的织带，所述牵开器包括构造成围绕旋转轴线卷绕和展开所述织带的卷轴，所述卷轴包括在其中具有开口的侧面; 包括外表面和内表面的套环，所述外表面被配置为接合所述开口; 锁定基座，其构造成可操作地接合所述内表面; 以及能量吸收构件，其构造成在所述线轴和所述锁定座之间的相对旋转时提供逐级的负载阻力水平。