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公开(公告)号:US20170349675A1
公开(公告)日:2017-12-07
申请号:US15519679
申请日:2015-10-19
发明人: Yong TANG , Jiashuai LIU , Wenjie TAO
IPC分类号: C08F4/70 , C08F4/26 , C08F4/80 , C10G69/12 , C10G50/00 , C10M105/04 , C07F15/00 , C07F15/04 , C08F8/04
CPC分类号: C08F4/7098 , C07D263/00 , C07D277/00 , C07F15/0066 , C07F15/04 , C07F15/045 , C08F4/26 , C08F4/70 , C08F4/7034 , C08F4/80 , C08F8/04 , C08F10/00 , C10G50/00 , C10G69/126 , C10G2300/302 , C10G2400/10 , C10M105/04 , C10M2203/022 , C10N2220/021 , C10N2220/022 , C10N2230/02 , C08F110/14 , C08F4/7006 , C08F110/02 , C08F110/08 , C08F2500/02 , C08F2500/09 , C08F2500/17
摘要: Disclosed is a new polyolefin catalyst and preparation therefor. Specifically, disclosed is a catalytic system comprising a new complex of iron, cobalt, nickel, palladium, and platinum. In the presence of the catalytic system, oily polyethylene can be efficiently obtained from simple olefins such as ethylene under mild conditions, highly branched oily alkane mixture is then obtained after hydrogenation. The alkane mixture can be used as a processing aid and a high-performance lubricant base oil. The present invention also provides a method for preparing the catalyst, a method for preparing the highly branched oily alkane mixture and a method for preparing functional polyolefin oil.
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公开(公告)号:US20050250784A1
公开(公告)日:2005-11-10
申请号:US11075603
申请日:2005-03-08
申请人: Sampath Anandan , Xiao-Yi Xiao , Dinesh Patel , John Ward
发明人: Sampath Anandan , Xiao-Yi Xiao , Dinesh Patel , John Ward
IPC分类号: A61K31/496 , A61K31/5377 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/14
CPC分类号: C07D277/00 , C07D417/04 , C07D417/14
摘要: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
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公开(公告)号:US20180064694A1
公开(公告)日:2018-03-08
申请号:US15556972
申请日:2016-03-08
发明人: Sanford Markowitz , Stanton Gerson , Amar Desai , Won Jin Ho
IPC分类号: A61K31/4365 , A61K31/426 , C07D277/02
CPC分类号: A61K31/4365 , A61K31/426 , C07D277/00 , C07D277/02 , Y02A50/423
摘要: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
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4.
公开(公告)号:US20100222217A1
公开(公告)日:2010-09-02
申请号:US11989973
申请日:2006-08-02
申请人: Markus Gewehr , Jochen Dietz , Thomas Grote , Wassilios Grammenos , Bernd Müller , Jan Klaas Lohmann
发明人: Markus Gewehr , Jochen Dietz , Thomas Grote , Wassilios Grammenos , Bernd Müller , Jan Klaas Lohmann
IPC分类号: A01N25/26 , C07D231/40 , A01N43/56 , C07D277/46 , A01N43/78 , C07D213/75 , A61K31/44 , A01P3/00
CPC分类号: C07D213/02 , A01N43/40 , A01N43/56 , A01N43/78 , C07D231/10 , C07D277/00 , C07D277/02 , C07D277/20
摘要: N-[2-(Haloalkoxy)phenyl]heteroarylcarboxamides of the formula I, where n=0 or 1, Hal=halogen, X=C2-C4-haloalkyl, Het=a pyrazole, thiazole or pyridine radical (a), (b) or (c), where R1=C1-C4-alkyl or C1-C4-haloalkyl, R2=hydrogen or halogen, R3=C1-C4-alkyl or C1-C4-haloalkyl and R5=halogen, C1-C4-alkyl or C1-C4-haloalkyl; except for N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1,3-dimethylpyrazol-4-yl-carboxamide, N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-trifluoromethyl-1-methylpyrazol-4-yl-carboxamide and N-[2-(2,2,2-trifluorethoxy)phenyl]-3-trifluormethyl-1-methylpyrazol-4-yl-carboxamide. A fungicidal composition comprising at least one compound I, the use of the compounds I for preparing a composition suitable for controlling harmful fungi, a method for controlling harmful fungi using the compounds I and also seed comprising at least one compound I.
摘要翻译: 式I的N- [2-(卤代烷氧基)苯基]杂芳基甲酰胺,其中n = 0或1,Hal =卤素,X = C 2 -C 4 - 卤代烷基,Het =吡唑,噻唑或吡啶基(a),(b )或(c)中,其中R 1 = C 1 -C 4 - 烷基或C 1 -C 4 - 卤代烷基,R 2 =氢或卤素,R 3 = C 1 -C 4 - 烷基或C 1 -C 4卤代烷基,R 5 =卤素,C 1 -C 4 - 烷基 或C 1 -C 4 - 卤代烷基; 除了N- [2-(1,1,2,2-四氟乙氧基)苯基] -1,3-二甲基吡唑-4-基 - 甲酰胺,N- [2-(1,1,2,2-四氟乙氧基)苯基 ] -3-三氟甲基-1-甲基吡唑-4-基甲酰胺和N- [2-(2,2,2-三氟乙氧基)苯基] -3-三氟甲基-1-甲基吡唑-4-基 - 甲酰胺。 包含至少一种化合物I的杀真菌组合物,使用化合物I制备适于控制有害真菌的组合物,使用化合物I控制有害真菌的方法,还包含至少一种化合物I的种子。
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公开(公告)号:US20170322231A1
公开(公告)日:2017-11-09
申请号:US15585773
申请日:2017-05-03
IPC分类号: G01N33/94 , G01N33/493
CPC分类号: G01N33/94 , A61B5/00 , A61K31/075 , A61K31/10 , A61K31/13 , C07D277/00 , C07D307/00 , G01N33/493 , G01N2560/00 , G01N2800/52
摘要: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.
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公开(公告)号:US20090325944A1
公开(公告)日:2009-12-31
申请号:US12226151
申请日:2007-04-11
IPC分类号: A61K31/54 , C07D279/06 , C07D263/58 , C07D409/04 , C07D215/227 , C07D239/22 , C07D235/26 , C07D471/04 , A61K31/423 , A61K31/4725 , A61K31/47 , A61K31/513 , A61K31/4184 , A61K31/519 , A61K31/4436 , C07H21/04 , C07K14/00 , C12Q1/68 , A61P3/00 , A61P9/00
CPC分类号: C07D401/12 , C07D215/36 , C07D235/26 , C07D239/60 , C07D239/70 , C07D263/58 , C07D277/00 , C07D279/06 , C07D409/04 , C07D409/14 , C07D417/12 , C07D513/04
摘要: The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.
摘要翻译: 本发明涉及调节蛋白质糖基化的方法和产品。 本发明对于治疗糖基化相关疾病如神经变性,糖尿病,包括糖尿病并发症如胰岛素抵抗,肾病,微血管损伤和内皮功能障碍是有用的。 本发明还部分涉及用于鉴定和测试用于调节蛋白质糖基化的候选化合物的测定。
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公开(公告)号:US20050197336A1
公开(公告)日:2005-09-08
申请号:US10992303
申请日:2004-11-17
申请人: Sampath Anandan , Xiao-Yi Xiao , Dinesh Patel , John Ward
发明人: Sampath Anandan , Xiao-Yi Xiao , Dinesh Patel , John Ward
IPC分类号: A61K31/496 , A61K31/5377 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/14
CPC分类号: C07D277/00 , C07D417/04 , C07D417/14
摘要: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
摘要翻译: 公开了抑制组蛋白脱乙酰酶(HDAC)酶活性的化合物。 还公开了包含这些化合物的药物组合物以及至少部分由HDAC介导的治疗条件,特别是增殖病症的方法。
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