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公开(公告)号：US08791245B2
公开(公告)日：2014-07-29
申请号：US13122428
申请日：2009-10-02
申请人： Warren Charles Kett , Yugang Chen
发明人： Warren Charles Kett , Yugang Chen
IPC分类号： C07H15/234 , A61K31/7036
CPC分类号： A61K47/4823 , A61K31/702 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7056 , A61K47/48092 , A61K47/549 , A61K47/61 , C07H3/06 , C07H5/06 , C07H5/10 , C07H13/12 , C07H15/14 , C07H15/203 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/236 , C07H15/238 , C07H15/26 , C07H19/056
摘要： The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.
摘要翻译： 本发明涉及可用于模拟称为糖胺聚糖（GAG）的阴离子生物活性分子的结构和/或活性的糖基化细菌代谢物的阴离子缀合物。 本发明还涉及制备缀合物的方法。 这样的缀合物可用于预防和/或治疗疾病状况，特别是慢性疾病病症，例如炎症（包括过敏性）疾病，转移性癌症和包括细菌，病毒或寄生虫在内的病原体感染。
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公开(公告)号：US20110190233A1
公开(公告)日：2011-08-04
申请号：US13122428
申请日：2009-10-02
申请人： Warren Charles Kett , Yugang Chen
发明人： Warren Charles Kett , Yugang Chen
IPC分类号： A61K31/7036 , C07H5/06 , A61K31/7028 , A61P29/00 , A61P35/04 , A61P31/04 , A61P31/12 , A61P33/00 , A61K31/7056 , C07H15/232
CPC分类号： A61K47/4823 , A61K31/702 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7056 , A61K47/48092 , A61K47/549 , A61K47/61 , C07H3/06 , C07H5/06 , C07H5/10 , C07H13/12 , C07H15/14 , C07H15/203 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/236 , C07H15/238 , C07H15/26 , C07H19/056
摘要： The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.
摘要翻译： 本发明涉及可用于模拟称为糖胺聚糖（GAG）的阴离子生物活性分子的结构和/或活性的糖基化细菌代谢物的阴离子缀合物。 本发明还涉及制备缀合物的方法。 这样的缀合物可用于预防和/或治疗疾病状况，特别是慢性疾病病症，例如炎症（包括过敏性）疾病，转移性癌症和包括细菌，病毒或寄生虫在内的病原体感染。
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">3.发明授权3"-Deoxystreptomycin production thereof and pharmaceutical compositions containing same 失效3“ - 其中含有霉菌霉素及含有它们的药物组合物
公开(公告)号：US4473557A
公开(公告)日：1984-09-25
申请号：US475269
申请日：1983-03-09
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Takayuki Usui
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Takayuki Usui
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/238 , A61K31/71 , C07H15/22
CPC分类号： C07H15/238 , Y02P20/55
摘要： A new semi-synthetic antibiotic, 3"-deoxystreptomycin is now provided, which is useful as an antibacterial agent and is produced from 3"-deoxydihydrostreptomycin by a process comprising oxidizing the 3'-hydroxymethyl group of 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxydihydrostreptomycin as prepared by skilled introduction of amino-protecting group and hydroxyl-protecting group of appropriately selected natures into 3"-deoxydihydrostreptomycin, and then removing the protective groups from the oxidation product, 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxystreptomycin.
摘要翻译： 现在提供一种新的半合成抗生素3'-脱氧链霉素，其可用作抗菌剂并且由3'-脱氧双氢链霉素通过包括氧化2,5,6的3'-羟甲基的方法制备， 4“，6” - 五-O-乙酰基-2“ - N-苄氧羰基-3” - 脱氧二氢嘧啶霉素，由熟练引入氨基保护基和适当选择的性质的羟基保护基制成3' 脱氧链霉素，然后从氧化产物2,5,6,4'，6“ - 五-O-乙酰基-2”-N-苄氧羰基-3“ - 脱氧链霉素中除去保护基团。
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4.发明授权Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby 失效使用过渡金属盐和中间体在氨基酸中选择性阻断氨基酸功能的过程
公开(公告)号：US4136254A
公开(公告)日：1979-01-23
申请号：US697297
申请日：1976-06-17
IPC分类号： C07B51/00 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07B31/00 , C07C67/00 , C07C231/02 , C07C239/00 , C07C269/00 , C07F1/00 , C07H1/00 , C07H15/22 , C07H15/222 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/236 , C07H15/238 , C07H23/00
CPC分类号： C07H23/00 , C07H15/222 , C07H15/238
摘要： Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and hydroxyl group pairs in said polyamino organic compound, followed by introduction of blocking groups on the non-complexed amino groups and, finally, removing the transition metal cations from the selectively N-blocked polyamino organic compound complex to obtain a polyamino organic compound having selectively blocked amino groups.This process is particularly valuable when carrying out aminocyclitol-aminoglycoside transformations utilizing transition metal salt complexes of cupric acetate, nickel (II) acetate, cobalt (II) acetate or mixtures thereof.
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公开(公告)号：US3989598A
公开(公告)日：1976-11-02
申请号：US777876
申请日：1968-11-21
申请人： Sylvie Pinnert , Leon Ninet , Jean Preud'Homme
发明人： Sylvie Pinnert , Leon Ninet , Jean Preud'Homme
IPC分类号： C07H15/238 , C07H15/252 , C12D9/14
CPC分类号： C07H15/252 , C07H15/238 , Y10S435/886
摘要： The invention provides the novel antibiotic known as daunorubicin (13057 RP) which has a powerful anti-cancer effect and is also an anti-bacterial agent. This antibiotic is a constituent of a mixture of three antibiotics, called 9865 R.P., produced by aerobic culture of one of the strains of Streptomyces, NRRL 3046 and 3045.
摘要翻译： 本发明提供了称为柔红霉素（13057RP）的抗生素，其具有强大的抗癌作用，也是抗细菌剂。 该抗生素是三种抗生素混合物的组成成分，称为9865 R.P.，其通过链霉菌菌株，NRRL 3046和3045的有氧培养产生。
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公开(公告)号：US3583973A
公开(公告)日：1971-06-08
申请号：US3583973D
申请日：1968-04-19
申请人： LAB ALBERT ROLLAND
发明人： ROLLAND MICHEL , VALETTE RAYMOND
IPC分类号： C07H15/232 , C07H15/236 , C07H15/238 , C07C129/18 , C07D7/00
CPC分类号： C07H15/234 , C07H15/232 , C07H15/238
摘要： THE INVENTION PROVIDES SALTS OF BASIC ANTIBIOTICS WITH EUCALYPTOL MONO- OR DI-SULPHONIC ACID. THERE NEW SALTS HAVE THE SAME UTILITY AS THE PARENT ANTIBIOTICS BUT MARKEDLY REDUCED TOXICITY.
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公开(公告)号：US3389139A
公开(公告)日：1968-06-18
申请号：US55467066
申请日：1966-06-02
申请人： WANDER AG DR A
IPC分类号： C07H15/238
CPC分类号： C07H15/238 , Y10S514/96
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8.发明授权Salts of dihydrodesoxystreptobiosamines and process for the preparation thereof 失效二氢去氧代维生素胺的盐及其制备方法
公开(公告)号：US3197461A
公开(公告)日：1965-07-27
申请号：US17360162
申请日：1962-01-16
申请人： RIKAGAKU KENKYUSHO
发明人： HIROSHI IKEDA , HATSUKO IKEDA
IPC分类号： C07H15/12 , C07H15/238
CPC分类号： C07H15/12 , C07H15/238
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公开(公告)号：US2882270A
公开(公告)日：1959-04-14
申请号：US60596056
申请日：1956-08-24
申请人： SCHENLEY IND INC
IPC分类号： C07H15/238
CPC分类号： C07H15/238
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10.发明授权1, 3-disubstituted-2-streptomycyl-tetrahydroimidazole, acid addition salts thereof, and therapeutic compositions containing same 失效1,3-二取代-2-链霉亲合 - 四氢咪唑，其酸加成盐和含有它们的治疗组合物
公开(公告)号：US2767116A
公开(公告)日：1956-10-16
申请号：US35762053
申请日：1953-05-26
申请人： BRISTOL LAB INC
发明人： CHENEY LEE C
IPC分类号： C07D233/02 , C07H15/238
CPC分类号： C07D233/02 , C07H15/238
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