公开(公告)号：US20240270796A1

公开(公告)日：2024-08-15

申请号：US18494219

申请日：2023-10-25

申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： Xinle Cui ,  Clifford M. Snapper

IPC分类号： C07K14/005 ,  A61K39/245 ,  A61K39/25 ,  A61P31/22 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/245 ,  A61K39/25 ,  A61P31/22 ,  C12N7/00 ,  C12N2710/16034 ,  C12N2710/16071 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2710/16234 ,  C12N2710/16271 ,  C12N2710/16334 ,  C12N2710/16371 ,  C12N2710/16634 ,  C12N2710/16671 ,  C12N2710/16734 ,  C12N2710/16771

摘要： Provided are antigenic compositions and uses thereof that include at least two human herpesvirus (HHV) polypeptides involved in mediating HHV binding, fusion, and entry into host cells, such as gp350, gH, gL, and gB, or nucleic acids encoding the polypeptides. The two HHV polypeptides comprise any combination of: a gB polypeptide; a gp350 polypeptide; a gL polypeptide; and a gH polypeptide, and optionally any one or more of the following polypeptides: gp42, gM, gN, gl, gC, gE, gD, ORF68, BMRF-2, BDLF2, UL128, UL130, UL131A, and gpK8.1. Also disclosed are methods of inducing an immune response or treating or preventing O an HHV infection in a subject by administering to the subject at least two of the HHV polypeptides or nucleic acid(s) encoding the same. Methods of passively transferring immunity using high-titer anti-HHV antibodies or immune cells are also disclosed.

公开(公告)号：US20090246226A1

公开(公告)日：2009-10-01

申请号：US12078307

申请日：2008-03-28

申请人： Motoyuki Esaki ,  Takanori Sato ,  Kristi M. Dorsey

发明人： Motoyuki Esaki ,  Takanori Sato ,  Kristi M. Dorsey

IPC分类号： A61K39/245 ,  C12N7/01 ,  A61P31/22

CPC分类号： A61K39/12 ,  A61K39/00 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N2710/14122 ,  C12N2710/14134 ,  C12N2710/16343 ,  C12N2710/16371 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The present invention provides a poultry vaccine containing a positive marker gene. More specifically, recombinant turkey herpesvirus modified by the presence of an extraneous antigen gene that may be used as a positive marker to identify and track vaccinated animals is provided. When inoculated into host animals, a poultry vaccine comprising the recombinant turkey herpesvirus provided in the present invention can elicit serological immune responses to the marker gene product that may be detected by serological assays such as enzyme-linked immunosorbent assay and serum agglutination test, thus enabling easy identification and tracking of vaccinated animals.

摘要翻译： 本发明提供含有阳性标记基因的家禽疫苗。 更具体地，提供了可以用作阳性标记物以鉴定和跟踪接种疫苗的动物的外来抗原基因存在而修饰的重组火鸡疱疹病毒。 当接种到宿主动物中时，包含本发明提供的重组火鸡疱疹病毒的家禽疫苗可引起可通过血清学检测如酶联免疫吸附测定和血清凝集试验检测的标记基因产物的血清学免疫应答，从而使 容易识别和跟踪疫苗接种的动物。

公开(公告)号：US20160220657A1

公开(公告)日：2016-08-04

申请号：US14915534

申请日：2014-09-05

申请人： CEVA SANTE ANIMALE

发明人： Motoyuki Esaki ,  Shuji Saitoh ,  Takanori Sato

IPC分类号： A61K39/12 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2710/16371 ,  C12N2720/10034 ,  C12N2720/10051 ,  C12N2720/10071 ,  C12N2760/16034 ,  C12N2760/18134

摘要： The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组病毒及其用途。 更具体地说，本发明涉及编码感兴趣多肽的新型重组马立克氏病病毒，以及它们用于将这些多肽表达或递送到动物，特别是家禽的用途。 本发明特别适用于针对禽类病原体接种家禽。

公开(公告)号：US20170043006A1

公开(公告)日：2017-02-16

申请号：US15228912

申请日：2016-08-04

申请人： The Texas A&M University System

发明人： Sanjay M. Reddy ,  Blanca M. Lupiani

IPC分类号： A61K39/12 ,  A61K39/255 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  A61P31/12 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16371 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10071

摘要： The present disclosure provides a recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome for treatment of diseases in poultry. Also provided are immunogenic compositions comprising such recombinant viral vectors and methods for preventing or inhibiting Marek's disease in combination with at least a second disease in poultry.

摘要翻译： 本公开提供了包含插入马立克氏病病毒基因组中的至少一种转基因用于治疗家禽疾病的重组病毒载体。 还提供了包含这种重组病毒载体的免疫原性组合物和用于预防或抑制马立克氏病与家禽中至少第二种疾病相结合的方法。

公开(公告)号：US20110311994A1

公开(公告)日：2011-12-22

申请号：US12448105

申请日：2009-03-16

申请人： Motoyuki Esaki ,  Takanori Sato ,  Kristi M. Dorsey

发明人： Motoyuki Esaki ,  Takanori Sato ,  Kristi M. Dorsey

IPC分类号： G01N33/53 ,  C12N7/01

CPC分类号： A61K39/12 ,  A61K39/00 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N2710/14122 ,  C12N2710/14134 ,  C12N2710/16343 ,  C12N2710/16371 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The present invention provides a poultry vaccine containing a positive marker gene. More specifically, recombinant turkey herpesvirus modified by the presence of an extraneous antigen gene that may be used as a positive marker to identify and track vaccinated animals is provided. When inoculated into host animals, a poultry vaccine comprising the recombinant turkey herpesvirus provided in the present invention can elicit serological immune responses to the marker gene product that may be detected by serological assays such as enzyme-linked immunosorbent assay and serum agglutination test, thus enabling easy identification and tracking of vaccinated animals.

摘要翻译： 本发明提供含有阳性标记基因的家禽疫苗。 更具体地，提供了可以用作阳性标记物以鉴定和跟踪接种疫苗的动物的外来抗原基因存在而修饰的重组火鸡疱疹病毒。 当接种到宿主动物中时，包含本发明提供的重组火鸡疱疹病毒的家禽疫苗可引起可通过血清学检测如酶联免疫吸附测定和血清凝集试验检测的标记基因产物的血清学免疫应答，从而使 容易识别和跟踪疫苗接种的动物。