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    PRRSV vaccines
    6.
    发明授权
    PRRSV vaccines 失效
    PRRSV疫苗

    公开(公告)号：US08790656B2

    公开(公告)日：2014-07-29

    申请号：US11422970

    申请日：2006-06-08

    申请人： Johanna Jacoba Maria Meulenberg ,  Monique Helene Verheije

    发明人： Johanna Jacoba Maria Meulenberg ,  Monique Helene Verheije

    IPC分类号： C12N15/86 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/5256 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10043 ,  C12N2770/10061

    摘要： The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines and diagnostic assays obtainable by using and modifying such infectious clones of PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous microorganism.

    摘要翻译： 本发明涉及从PRRS病毒获得的PRRS病毒和感染性克隆的领域。 此外，本发明涉及通过使用和修饰PRRS病毒感染性克隆而获得的疫苗和诊断测定法。 本发明提供了具有其原始PRRSV核酸的至少一些缺失的猪繁殖和呼吸综合征病毒（PRRSV）复制子，所述复制子能够进行体内RNA复制，所述复制子还被剥夺了其原始PRRSV核酸的至少一些 酸和/或已经补充有源自异源微生物的核酸。

    Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof
    8.
    发明申请
    Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof 有权
    北美猪繁殖与呼吸综合征（PRRS）病毒及其用途的传染性cDNA克隆

    公开(公告)号：US20110040080A1

    公开(公告)日：2011-02-17

    申请号：US12619880

    申请日：2009-11-17

    申请人： Jay Gregory Calvert ,  Michael G. Sheppard ,  Siao-Kun W. Welch ,  Raymond R.R. Rowland ,  Dal-Young Kim

    发明人： Jay Gregory Calvert ,  Michael G. Sheppard ,  Siao-Kun W. Welch ,  Raymond R.R. Rowland ,  Dal-Young Kim

    IPC分类号： C07H21/04

    CPC分类号： C07K14/005 ,  A61K2039/525 ,  A61K2039/53 ,  C12N15/86 ,  C12N2770/10022 ,  C12N2770/10043

    摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

    摘要翻译： 本发明提供分离的多核苷酸分子，包括质粒; 病毒载体; 和包含编码编码北美PRRS病毒的感染性RNA序列的DNA序列的转染宿主细胞; 以及由此编码的北美PRRS病毒。 本发明还提供编码北美PRRS病毒的分离的感染性RNA分子。 本发明还提供分离的多核苷酸分子，感染性RNA分子，病毒载体和编码经遗传修饰的北美PRRS病毒的转染宿主细胞; 和由此编码的转基因北美PRRS病毒。 本发明还提供包含这样的质粒，RNA分子，病毒载体和北美PRRS病毒的疫苗，以及在猪和其他动物中使用这些疫苗的方法。 还提供了分离的多核苷酸分子，病毒载体和包含编码北美PRRS病毒的肽的核苷酸序列的转染宿主细胞。 这些病毒载体和转染的宿主细胞系可用于提供肽以补偿编码经遗传修饰的北美PRRS病毒的DNA序列的突变的肽编码序列，从而可以产生功能性病毒体。