公开(公告)号：US20240318202A1

公开(公告)日：2024-09-26

申请号：US18574777

申请日：2022-06-30

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Arun Dhar ,  Arjoneel Dhar ,  Rod Russel R. Alenton

IPC分类号： C12N15/86 ,  C12N9/22 ,  C12N15/113

CPC分类号： C12N15/86 ,  C12N9/22 ,  C12N15/113 ,  C12N2310/20 ,  C12N2310/531 ,  C12N2770/30043

摘要： Described herein are engineered nodaviral vectors, systems, and uses thereof. In some embodiments, the engineered nodaviral vectors and/or systems can be used to deliver a cargo, such as a nucleic acid cargo, to a cell or cell population, or a subject. In some embodiments, the cargo is a therapeutic or preventative.

公开(公告)号：US09644188B2

公开(公告)日：2017-05-09

申请号：US14254886

申请日：2014-04-16

申请人： Aln Rao ,  Jang-Kyung Seo

发明人： Aln Rao ,  Jang-Kyung Seo

IPC分类号： C12N7/00 ,  C12N7/02 ,  A61K39/12 ,  C07K14/005

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N7/025 ,  C12N2770/30022 ,  C12N2770/30043 ,  C12N2770/30052

摘要： Certain embodiments of the invention relate to mutant forms of flock house virus B2 protein characterized by having enhanced suppressor of RNA silencing activity as compared to wild type flock house virus B2 protein. Certain embodiments of the invention relate to nucleic acid sequences and vectors that encode and/or direct expression of such mutant forms of flock house virus B2 protein in eukaryotic cells. Certain embodiments of the invention relate to methods of using such mutant forms of flock house virus B2 protein and/or nucleic acid sequences and vectors that encode and/or direct expression thereof in eukaryotic cells to increase a replication rate of a plant or animal virus in a plant or animal cell.

公开(公告)号：US20160251630A9

公开(公告)日：2016-09-01

申请号：US14254886

申请日：2014-04-16

申请人： ALN Rao ,  Jang-Kyung Seo

发明人： ALN Rao ,  Jang-Kyung Seo

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N7/025 ,  C12N2770/30022 ,  C12N2770/30043 ,  C12N2770/30052

摘要： Certain embodiments of the invention relate to mutant forms of flock house virus B2 protein characterized by having enhanced suppressor of RNA silencing activity as compared to wild type flock house virus B2 protein. Certain embodiments of the invention relate to nucleic acid sequences and vectors that encode and/or direct expression of such mutant forms of flock house virus B2 protein in eukaryotic cells. Certain embodiments of the invention relate to methods of using such mutant forms of flock house virus B2 protein and/or nucleic acid sequences and vectors that encode and/or direct expression thereof in eukaryotic cells to increase a replication rate of a plant or animal virus in a plant or animal cell.

公开(公告)号：US20160040133A1

公开(公告)日：2016-02-11

申请号：US14254886

申请日：2014-04-16

申请人： ALN Rao ,  Jang-Kyung Seo

发明人： ALN Rao ,  Jang-Kyung Seo

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N7/025 ,  C12N2770/30022 ,  C12N2770/30043 ,  C12N2770/30052

摘要： Certain embodiments of the invention relate to mutant forms of flock house virus B2 protein characterized by having enhanced suppressor of RNA silencing activity as compared to wild type flock house virus B2 protein. Certain embodiments of the invention relate to nucleic acid sequences and vectors that encode and/or direct expression of such mutant forms of flock house virus B2 protein in eukaryotic cells. Certain embodiments of the invention relate to methods of using such mutant forms of flock house virus B2 protein and/or nucleic acid sequences and vectors that encode and/or direct expression thereof in eukaryotic cells to increase a replication rate of a plant or animal virus in a plant or animal cell.

摘要翻译： 本发明的某些实施方案涉及与野生型鸡群病毒B2蛋白相比具有增强的沉默沉默活性抑制因子的鸡群病毒B2蛋白质的突变形式。 本发明的某些实施方案涉及在真核细胞中编码和/或直接表达这些突变形式的鸡群病毒B2蛋白的核酸序列和载体。 本发明的某些实施方案涉及使用这种突变形式的鸡群病毒B2蛋白和/或核酸序列的方法和在真核细胞中编码和/或直接表达其的载体，以增加植物或动物病毒的复制率 植物或动物细胞。

公开(公告)号：US06700038B1

公开(公告)日：2004-03-02

申请号：US09281851

申请日：1999-03-31

申请人： Ranjit K. Dasgputa ,  Robert Goodman

发明人： Ranjit K. Dasgputa ,  Robert Goodman

IPC分类号： C12N1582

CPC分类号： C12N15/8203 ,  C12N15/86 ,  C12N2770/30043 ,  C12N2810/65

摘要： The invention provides insect viral vectors useful to transfer genes to plants, insects and other hosts.

摘要翻译： 本发明提供了可用于将基因转移至植物，昆虫和其他宿主的昆虫病毒载体。