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公开(公告)号：US11685768B2
公开(公告)日：2023-06-27
申请号：US15580320
申请日：2016-06-24
发明人： Irina Borodina , Carina Holkenbrink , Marie Inger Dam , Christer Löfstedt , Baojian Ding , Hong-Lei Wang
IPC分类号： C12P7/04 , C07K14/435 , C12P7/24 , C12P7/6436 , C12N1/16
CPC分类号： C07K14/43563 , C12N1/16 , C12P7/04 , C12P7/24 , C12P7/6436 , C12Y102/01084 , C12Y114/19005 , C12Y203/01086 , Y02P20/582
摘要： The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell using desaturases and fatty acyl-CoA reductase. Also disclosed are methods for production of (Z)-11-hexadecenal in a yeast cell. Also disclosed are methods for production of (Z)-11-hexadecen-1-yl acetate in a yeast cell. The disclosure also provides for nucleic acid constructs and yeast cells useful for performing the present methods, as well as to pheromone compositions.
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公开(公告)号：US20240076329A1
公开(公告)日：2024-03-07
申请号：US18144503
申请日：2023-05-08
发明人： Irina Borodina , Carina Holkenbrink , Marie Inger Dam , Christer Löfstedt , Baojian Ding , Hong-Lei Wang
IPC分类号： C07K14/435 , C12N1/16 , C12P7/04 , C12P7/24 , C12P7/6436
CPC分类号： C07K14/43563 , C12N1/16 , C12P7/04 , C12P7/24 , C12P7/6436 , C12Y102/01084 , C12Y114/19005 , C12Y203/01086 , Y02P20/582
摘要： The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell. Also disclosed are methods for production of (Z)-11-hexadecenal in a yeast cell. Also disclosed are methods for production of (Z)-11-hexadecen-1-yl acetate in a yeast cell. The disclosure also provides for nucleic acid constructs and yeast cells useful for performing the present methods, as well as to pheromone compositions.
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公开(公告)号：US20230242945A1
公开(公告)日：2023-08-03
申请号：US18161794
申请日：2023-01-30
申请人： Jan Christer Lofstedt , Per Fredrik Hofvander , Honglei Wang , Baojian Ding , ISCA Technologies, Inc.
发明人： Jan Christer Löfstedt , Per Fredrik Hofvander , Honglei Wang , Baojian Ding , Agenor Mafra-Neto
CPC分类号： C12P7/04 , C12N9/0008 , C12N9/0071 , C12Y114/19005
摘要： The present invention relates to methods of producing Amyelois transitella pheromone precursors and genetically modified plants and microorganisms capable of producing Amyelois transitella pheromone precursors. The genetically modified plants and microorganisms include a heterologous gene encoding a first fatty-acyl desaturase and a second fatty-acyl desaturase in combination, and a fatty-acyl reductase.
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公开(公告)号：US20240287555A1
公开(公告)日：2024-08-29
申请号：US18570271
申请日：2022-07-01
IPC分类号： C12P7/6409 , C12N9/02 , C12P7/6436
CPC分类号： C12P7/6409 , C12N9/0008 , C12N9/0071 , C12P7/6436 , C12Y102/01084 , C12Y114/19 , C12Y114/19005
摘要： The present invention relates to yeast cells capable of producing Δ13 desaturated fatty acyl-CoAs and optionally desaturated fatty alcohols, said yeast cells expressing heterologous Δ13 desaturases. Said compounds are precursors of sex pheromone components of several insects, such as the navel orangeworm Amyelois transitella, the grape leaffolder Desmia funeralis, Cedar processionary moth Thaumetopoea bonjeani, the iron prominent Notodonta dromedarius, and others.
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公开(公告)号：US20180162916A1
公开(公告)日：2018-06-14
申请号：US15580320
申请日：2016-06-24
发明人： Irina Borodina , Carina Holkenbrink , Marie Inger Dam , Christer Löfstedt , Baojian Ding , Hong-Lei Wang
IPC分类号： C07K14/435 , C12P7/04 , C12P7/24 , C12P7/64 , C12N1/16
CPC分类号： C07K14/43563 , C12N1/16 , C12P7/04 , C12P7/24 , C12P7/6436 , C12Y102/01084 , C12Y114/19005 , C12Y203/01086 , Y02P20/582
摘要： The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell using desaturases and fatty acyl-CoA reductase. Also disclosed are methods for production of (Z)-11-hexadecenal in a yeast cell. Also disclosed are methods for production of (Z)-11-hexadecen-1-yl acetate in a yeast cell. The disclosure also provides for nucleic acid constructs and yeast cells useful for performing the present methods, as well as to pheromone compositions.
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公开(公告)号：US11884940B2
公开(公告)日：2024-01-30
申请号：US17550212
申请日：2021-12-14
申请人： Provivi, Inc.
CPC分类号： C12N9/0006 , C12N9/0071 , C12N9/18 , C12N15/52 , C12N15/815 , C12P7/6409 , C12Y101/0104 , C12Y101/01042 , C12Y101/01044 , C12Y101/01049 , C12Y114/19005 , C12Y301/01031
摘要： The present application relates to methods to improve biomass or lipid production in a microorganism from one or more fatty acid and one or more simple carbon co-substrates. Produced lipids may include unsaturated C6-C24 fatty acids, alcohols, aldehydes, and acetates which may be useful as final products or precursors to insect pheromones, fragrances, flavors, and polymer intermediates. The application further relates to recombinant microorganisms modified for improved production of biomass or lipid, or improved lipid selectivity. Also provided are methods of producing one or more lipid using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product lipid.
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公开(公告)号：US11844353B2
公开(公告)日：2023-12-19
申请号：US17408050
申请日：2021-08-20
申请人： Provivi, Inc.
发明人： Effendi Leonard , Peter Meinhold , Keith Wampler , Pedro Coelho , Micah Sheppard , Thomas Heel
IPC分类号： A01N63/50 , C12P7/6472 , C12P7/6436 , C12P7/62 , A01N3/02 , C12N9/02 , C12P7/04 , A01N31/02
CPC分类号： A01N63/50 , A01N31/02 , C12N9/0008 , C12N9/0071 , C12P7/04 , C12P7/62 , C12P7/6436 , C12P7/6472 , C12Y102/0105 , C12Y114/19001 , C12Y114/19005
摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C6-C24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C6-C24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C6-C24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.
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