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1.发明申请Microorganism Producing Inosine and Method of Producing Inosine Using the Same 有权生产肌苷的微生物及使用其产生肌苷的方法公开(公告)号：US20100081173A1
公开(公告)日：2010-04-01
申请号：US12522004
申请日：2008-01-15
申请人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
发明人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
CPC分类号： C12P19/32 , C12N9/16 , C12N9/2497 , C12P19/40 , C12Y302/02008
摘要： The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610).
摘要翻译： 本发明涉及一种生产肌苷的微生物，其是嘌呤核苷之一，是5'-肌苷酸合成的重要材料，以及使用其的产生肌苷的方法。 更具体地说，本发明涉及通过使编码核苷水解酶II的基因失活而产生高浓度肌苷的棒杆菌属的重组微生物，并且通过增强仍保留产氨棒杆菌CJIP2401的特征的编码5'-核苷酸酶的基因的表达， （KCCM-10610）。
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公开(公告)号：US08187840B2
公开(公告)日：2012-05-29
申请号：US13229166
申请日：2011-09-09
申请人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
发明人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
CPC分类号： C12P19/32 , C12N9/16 , C12N9/2497 , C12P19/40 , C12Y302/02008
摘要： The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610).
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3.发明授权Inosine producing microorganism belonging to the genus Corynebacterium and process of producing inosine using the same 有权产于棒杆菌属的产生肌苷的微生物及使用其产生肌苷的方法公开(公告)号：US08551736B2
公开(公告)日：2013-10-08
申请号：US12811778
申请日：2009-01-02
申请人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
发明人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
CPC分类号： C12P19/40 , C12N9/2497 , C12Y302/02001 , C12Y302/02008
摘要： A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.
摘要翻译： 能够产生肌苷分解代谢途径被阻断并具有渗漏的腺嘌呤营养缺陷型的肌氨酸杆菌属的微生物，并且还具有泄漏的鸟嘌呤营养缺陷型表型和产生肌苷的方法，该方法包括培养微生物 披露了棒状杆菌属。
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4.发明申请INOSINE PRODUCING MICROORGANISM BELONGING TO THE GENUS CORYNEBACTERIUM AND PROCESS OF PRODUCING INOSINE USING THE SAME 有权生产与根瘤菌相关的微生物的生产和使用其生产异辛烯的方法公开(公告)号：US20110003342A1
公开(公告)日：2011-01-06
申请号：US12811778
申请日：2009-01-02
申请人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
发明人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
CPC分类号： C12P19/40 , C12N9/2497 , C12Y302/02001 , C12Y302/02008
摘要： A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.
摘要翻译： 能够产生肌苷分解代谢途径被阻断并具有渗漏的腺嘌呤营养缺陷型的肌氨酸杆菌属的微生物，并且还具有泄漏的鸟嘌呤营养缺陷型表型和产生肌苷的方法，该方法包括培养微生物 披露了棒状杆菌属。
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5.发明授权Microorganism producing inosine and method of producing inosine using the same 有权生产肌苷的微生物及使用其产生肌苷的方法公开(公告)号：US08168422B2
公开(公告)日：2012-05-01
申请号：US12522004
申请日：2008-01-15
申请人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
发明人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
CPC分类号： C12P19/32 , C12N9/16 , C12N9/2497 , C12P19/40 , C12Y302/02008
摘要： The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610).
摘要翻译： 本发明涉及一种生产肌苷的微生物，其是嘌呤核苷之一，是5'-肌苷酸合成的重要材料，以及使用其的产生肌苷的方法。 更具体地说，本发明涉及通过使编码核苷水解酶II的基因失活而产生高浓度肌苷的棒杆菌属的重组微生物，并且通过增强仍保留产氨棒杆菌CJIP2401的特征的编码5'-核苷酸酶的基因的表达， （KCCM-10610）。
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6.发明申请Microorganism Producing Inosine and Method of Producing Inosine Using the Same 有权生产肌苷的微生物及使用其产生肌苷的方法公开(公告)号：US20110318783A1
公开(公告)日：2011-12-29
申请号：US13229166
申请日：2011-09-09
申请人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
发明人： Young-hoon Park , Kwang-myung Cho , Hee-jong Lee , Jin-nam Lee
IPC分类号： C12P19/40
CPC分类号： C12P19/32 , C12N9/16 , C12N9/2497 , C12P19/40 , C12Y302/02008
摘要： The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610).
摘要翻译： 本发明涉及一种生产肌苷的微生物，其是嘌呤核苷之一，是5'-肌苷酸合成的重要材料，以及使用其的产生肌苷的方法。 更具体地说，本发明涉及通过使编码核苷水解酶II的基因失活而产生高浓度肌苷的棒杆菌属的重组微生物，并且通过增强仍保留产氨棒杆菌CJIP2401的特征的编码5'-核苷酸酶的基因的表达， （KCCM-10610）。
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