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1.发明授权Inosine producing microorganism belonging to the genus Corynebacterium and process of producing inosine using the same 有权产于棒杆菌属的产生肌苷的微生物及使用其产生肌苷的方法公开(公告)号：US08551736B2
公开(公告)日：2013-10-08
申请号：US12811778
申请日：2009-01-02
申请人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
发明人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
CPC分类号： C12P19/40 , C12N9/2497 , C12Y302/02001 , C12Y302/02008
摘要： A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.
摘要翻译： 能够产生肌苷分解代谢途径被阻断并具有渗漏的腺嘌呤营养缺陷型的肌氨酸杆菌属的微生物，并且还具有泄漏的鸟嘌呤营养缺陷型表型和产生肌苷的方法，该方法包括培养微生物 披露了棒状杆菌属。
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2.发明申请INOSINE PRODUCING MICROORGANISM BELONGING TO THE GENUS CORYNEBACTERIUM AND PROCESS OF PRODUCING INOSINE USING THE SAME 有权生产与根瘤菌相关的微生物的生产和使用其生产异辛烯的方法公开(公告)号：US20110003342A1
公开(公告)日：2011-01-06
申请号：US12811778
申请日：2009-01-02
申请人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
发明人： Chul Ha Kim , Jong Soo Choi , Jeong Hwan Kim , Hyoung Seok Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Jae Ick Sim , Min Ji Baek , Na Ra Kwon , Hye Jin Choi
CPC分类号： C12P19/40 , C12N9/2497 , C12Y302/02001 , C12Y302/02008
摘要： A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genus Corynebacterium are disclosed.
摘要翻译： 能够产生肌苷分解代谢途径被阻断并具有渗漏的腺嘌呤营养缺陷型的肌氨酸杆菌属的微生物，并且还具有泄漏的鸟嘌呤营养缺陷型表型和产生肌苷的方法，该方法包括培养微生物 披露了棒状杆菌属。
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3.发明申请Microorganisms of Corynebacterium with Improved 5'-Inosinic Acid Productivity, and Method for Producing Nucleic Acids Using Same 审中-公开具有改善的5'-肌苷酸生产力的棒状杆菌的微生物和使用其产生核酸的方法公开(公告)号：US20120021466A1
公开(公告)日：2012-01-26
申请号：US13262202
申请日：2010-03-23
申请人： Jeong Hwan Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Min Ji Baek , Na Ra Kwon , Nan Young Yoon , Ju Jeong Kim
发明人： Jeong Hwan Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Min Ji Baek , Na Ra Kwon , Nan Young Yoon , Ju Jeong Kim
CPC分类号： C12P19/34 , C12N9/1235 , C12P19/32 , C12R1/15
摘要： The present invention relates to a microorganisms of the genus Corynebacterium producing 5′-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5′-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved 5′-inosinic acid productivity.
摘要翻译： 本发明涉及产生5'-肌苷酸的棒状杆菌属的微生物，其中编码嘌呤生物合成相关酶的基因的表达增加高于本征表达，并且涉及一种产生5'-肌苷酸的方法，包括 用5'-肌苷酸生产力培养棒状杆菌属的微生物。
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4.发明授权Microorganisms of Corynebacterium with improved 5′-inosinic acid productivity, and method for producing nucleic acids using same 有权具有改善的5'-肌苷酸生产力的棒状杆菌的微生物以及使用其的产生核酸的方法公开(公告)号：US08993272B2
公开(公告)日：2015-03-31
申请号：US13262202
申请日：2010-03-23
申请人： Jeong Hwan Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Min Ji Baek , Na Ra Kwon , Nan Young Yoon , Ju Jeong Kim
发明人： Jeong Hwan Kim , Jung Gun Kwon , Tae Min Ahn , Soo Youn Hwang , Min Ji Baek , Na Ra Kwon , Nan Young Yoon , Ju Jeong Kim
CPC分类号： C12P19/34 , C12N9/1235 , C12P19/32 , C12R1/15
摘要： The present invention relates to a microorganisms of the genus Corynebacterium producing 5′-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5′-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved 5′-inosinic acid productivity.
摘要翻译： 本发明涉及产生5'-肌苷酸的棒状杆菌属的微生物，其中编码嘌呤生物合成相关酶的基因的表达增加高于本征表达，并且涉及一种产生5'-肌苷酸的方法，包括 用5'-肌苷酸生产力培养棒状杆菌属的微生物。
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5.发明授权Corynebacterium glutamicum variety producing L-arginine and method for fabricating the same 有权产生L-精氨酸的谷氨酸棒杆菌品种及其制造方法公开(公告)号：US08048648B2
公开(公告)日：2011-11-01
申请号：US12522280
申请日：2008-01-11
申请人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
发明人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
CPC分类号： C12P13/10
摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.
摘要翻译： 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体 通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。 本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。
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6.发明申请MICROORGANISM HAVING ENHANCED L-VALINE PRODUCTIVITY AND METHOD FOR PRODUCING L-VALINE USING THE SAME 有权具有增强的L-精氨酸生产力的微生物和使用其生产L-缬氨酸的方法公开(公告)号：US20130045511A1
公开(公告)日：2013-02-21
申请号：US13310536
申请日：2011-12-02
申请人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
发明人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
摘要： The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.
摘要翻译： 本发明涉及具有增强的L-缬氨酸生产力的微生物和使用其的L-缬氨酸生产方法。 更具体地，本发明涉及对L-缬氨酸及其衍生物具有抗性的L-缬氨酸生产力提高的谷氨酸棒杆菌突变菌株和使用其的L-缬氨酸生产方法。
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7.发明授权Microorganism having enhanced L-valine productivity and method for producing L-valine using the same 有权具有增强的L-缬氨酸生产力的微生物和使用其生产L-缬氨酸的方法公开(公告)号：US08465962B2
公开(公告)日：2013-06-18
申请号：US13310536
申请日：2011-12-02
申请人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
发明人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
摘要： The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.
摘要翻译： 本发明涉及具有增强的L-缬氨酸生产力的微生物和使用其的L-缬氨酸生产方法。 更具体地，本发明涉及对L-缬氨酸及其衍生物具有抗性的L-缬氨酸生产力提高的谷氨酸棒杆菌突变菌株和使用其的L-缬氨酸生产方法。
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8.发明申请CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME 有权生产L-阿魏酸的罗丹明葡萄球菌及其制备方法公开(公告)号：US20100041109A1
公开(公告)日：2010-02-18
申请号：US12522280
申请日：2008-01-11
申请人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
发明人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
CPC分类号： C12P13/10
摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.
摘要翻译： 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体 通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。 本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。
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