公开(公告)号：US08932834B2

公开(公告)日：2015-01-13

申请号：US13404148

申请日：2012-02-24

申请人： Hidetaka Doi ,  Yoshihiro Usuda

发明人： Hidetaka Doi ,  Yoshihiro Usuda

IPC分类号： C12P13/08 ,  C12P13/12 ,  C12P13/22 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/78 ,  C12N9/80

CPC分类号： C12P13/08 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/78 ,  C12N9/80 ,  C12P13/12 ,  C12P13/227 ,  C12Y203/01109 ,  C12Y206/01081 ,  C12Y305/01096 ,  C12Y305/03023

摘要： A method for producing an L-amino acid which includes the steps of culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium, and collecting the L-amino acid from the medium, wherein the bacterium has been modified so that an activity or activities of one or two or more enzymes of the arginine succinyltransferase pathway, such as arginine succinyltransferase, succinylarginine dihydrolase, succinylornithine aminotransferase, succinylglutamate-semialdehyde dehydrogenase, and succinylglutamate desuccinylase, is/are decreased.

摘要翻译： 一种L-氨基酸的制造方法，其特征在于，在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌的步骤，在培养基中生成并积累L-氨基酸，并收集 来自培养基的L-氨基酸，其中所述细菌已被修饰，使得精氨酸琥珀酰转移酶途径的一种或两种或多种酶的活性或活性，例如精氨酸琥珀酰转移酶，琥珀酰精氨酸二水解酶，琥珀酰鸟氨酸氨基转移酶，琥珀酰谷氨酸 - 半醛脱氢酶和 琥珀酰谷氨酸脱琥珀酰基酶降低。

公开(公告)号：US20120219995A1

公开(公告)日：2012-08-30

申请号：US13404148

申请日：2012-02-24

申请人： Hidetaka Doi ,  Yoshihiro Usuda

发明人： Hidetaka Doi ,  Yoshihiro Usuda

IPC分类号： C12P13/04 ,  C12P13/22 ,  C12P13/12 ,  C12P13/08

CPC分类号： C12P13/08 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/78 ,  C12N9/80 ,  C12P13/12 ,  C12P13/227 ,  C12Y203/01109 ,  C12Y206/01081 ,  C12Y305/01096 ,  C12Y305/03023

摘要： A method for producing an L-amino acid which includes the steps of culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium, and collecting the L-amino acid from the medium, wherein the bacterium has been modified so that an activity or activities of one or two or more enzymes of the arginine succinyltransferase pathway, such as arginine succinyltransferase, succinylarginine dihydrolase, succinylornithine aminotransferase, succinylglutamate-semialdehyde dehydrogenase, and succinylglutamate desuccinylase, is/are decreased.

摘要翻译： 一种L-氨基酸的制造方法，其特征在于，在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌的步骤，在培养基中生成并积累L-氨基酸，并收集 来自培养基的L-氨基酸，其中所述细菌已被修饰，使得精氨酸琥珀酰转移酶途径的一种或两种或多种酶的活性或活性，例如精氨酸琥珀酰转移酶，琥珀酰精氨酸二水解酶，琥珀酰鸟氨酸氨基转移酶，琥珀酰谷氨酸 - 半醛脱氢酶和 琥珀酰谷氨酸脱琥珀酰基酶降低。