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公开(公告)号：US20160160251A1
公开(公告)日：2016-06-09
申请号：US14905325
申请日：2014-07-17
发明人： Wolfgang Wach , Thomas Rose
CPC分类号： C12P19/12 , C12N11/02 , C12N11/04 , C12P19/24 , C12Y504/99011
摘要： The present invention relates to a method for producing a composition containing isomaltulose from a substrate containing sucrose.
摘要翻译： 本发明涉及含有蔗糖的底物含异麦芽酮糖的组合物的制造方法。
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公开(公告)号：US20170002342A1
公开(公告)日：2017-01-05
申请号：US15123514
申请日：2015-03-03
申请人： Frank Hellmers , Thomas Hueller , Thomas Dassinger , Oliver Thum
发明人： Frank Hellmers , Thomas Hueller , Thomas Dassinger , Oliver Thum
CPC分类号： C12N9/98 , C08L33/04 , C08L33/12 , C12N9/90 , C12N11/16 , C12Y504/99011 , C08F220/14 , C08F2220/1808
摘要： The invention provides granules comprising A) at least one enzyme selected from at least one of the groups selected from transferases of EC 2, hydrolases of EC 3, lyases of EC 4 and isomerases of EC 5, B) at least one polymer selected from C1-C10-alkyl acrylate polymer, C1-C10-alkyl methacrylate polymer and C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer, preferably C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer and C) at least one inorganic carrier material.
摘要翻译： 本发明涉及含有A）至少一种选自由EC2转移酶，EC 3水解酶，EC 4裂解酶和EC 5异构酶组成的组中的至少一种的B）至少一种选自C1 C 10 - 烷基丙烯酸酯聚合物，甲基丙烯酸C1-C10烷基酯聚合物和丙烯酸C1-C10烷基酯 - 甲基丙烯酸C1-C10烷基酯共聚物，优选C1-C10烷基丙烯酸酯-C1-C10-烷基甲基丙烯酸酯共聚物，C） 至少一种无机载体材料。
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公开(公告)号：US20120225458A1
公开(公告)日：2012-09-06
申请号：US13509250
申请日：2010-10-23
申请人： Stefan Pelzer , Christian Zurek , Thomas Rose , Jürgen Eck , Wolfgang Wach , Michael Klingeberg , Karsten Harms
发明人： Stefan Pelzer , Christian Zurek , Thomas Rose , Jürgen Eck , Wolfgang Wach , Michael Klingeberg , Karsten Harms
IPC分类号： C12P19/24 , C12N1/21 , C12N15/113 , C12N15/63
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The invention relates to the biotechnological production of isomaltulose and isomaltulose-containing compositions and improved means, therefore particularly microbial cells.
摘要翻译： 本发明涉及异麦芽酮糖和含异麦芽酮糖的组合物的生物技术生产和改进的方法，因此特别是微生物细胞。
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公开(公告)号：US20180208956A1
公开(公告)日：2018-07-26
申请号：US15879757
申请日：2018-01-25
发明人： Wolfgang Wach , Thomas Rose
CPC分类号： C12P19/12 , C12N11/02 , C12N11/04 , C12P19/24 , C12Y504/99011
摘要： The present invention relates to a method for producing a composition containing isomaltulose from a substrate containing sucrose comprising the steps of: a) contacting the substrate containing sucrose with a particulate carrier-immobilized sucrose isomerase biomass and b) obtaining a composition containing isomaltulose, characterized in that the median particle size d(0.5) of the carrier-immobilized sucrose isomerase biomass is from 370 to 550 μm. The carrier can be an alginate or a polyvinyl alcohol carrier.
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公开(公告)号：US09885030B2
公开(公告)日：2018-02-06
申请号：US15605816
申请日：2017-05-25
发明人： Samir Kumar Roy , Saravanakumar Iyappan , Saju Varghese , Aparna Devi Addala , Milky Agarwal , Kanumuru Rahul Raju , Banibrata Pandey
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
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公开(公告)号：US20230372453A1
公开(公告)日：2023-11-23
申请号：US18030658
申请日：2021-10-07
申请人： ZBiotics Company
IPC分类号： A61K38/45 , C12N9/10 , C12N9/90 , C12N15/75 , C12N1/20 , A61K35/747 , A61K35/745 , A61K35/744 , A61K35/742 , A61K38/47
CPC分类号： A61K38/45 , C12N9/1055 , C12Y204/0101 , C12N9/90 , C12Y504/99011 , C12N15/75 , C12N1/20 , A61K35/747 , A61K35/745 , A61K35/744 , A61K35/742 , A61K38/47 , C12N2800/101
摘要： The present disclosure provides solutions to various challenges in health, including health challenges related to high consumption of carbohydrate and/or low consumption of soluble fiber. The present disclosure provides, among other things, bacteria engineered for expression of a fiber-synthesizing enzyme, e.g., for expression of the enzyme in the gut (e.g., in the intestine). In particular embodiments, the present disclosure provides bacteria engineered for expression of a fiber-synthesizing enzyme that consumes carbohydrate in the process of synthesizing fiber, e.g., in the gut. The present disclosure further includes formulations of isolated fiber-synthesizing enzymes for administration to subjects.
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公开(公告)号：US09920344B2
公开(公告)日：2018-03-20
申请号：US14905325
申请日：2014-07-17
发明人： Wolfgang Wach , Thomas Rose
IPC分类号： G01N33/554 , C12P19/24 , C12P19/12 , C12N11/04 , C12N11/02
CPC分类号： C12P19/12 , C12N11/02 , C12N11/04 , C12P19/24 , C12Y504/99011
摘要： The present invention relates to a method for producing a composition containing isomaltulose from a substrate containing sucrose comprising the steps of: a) contacting the substrate containing sucrose with a particulate carrier-immobilized sucrose isomerase biomass and b) obtaining a composition containing isomaltulose, characterized in that the median particle size d(0.5) of the carrier-immobilized sucrose isomerase biomass is from 370 to 550 μm. The carrier can be an alginate or a polyvinyl alcohol carrier.
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公开(公告)号：US20170267989A1
公开(公告)日：2017-09-21
申请号：US15605816
申请日：2017-05-25
发明人： Samir Kumar Roy , Saravanakumar Iyappan , Saju Varghese , Aparna Devi Addala , Milky Agarwal , Kanumuru Rahul Raju , Banibrata Pandey
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
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公开(公告)号：US09695411B2
公开(公告)日：2017-07-04
申请号：US14655035
申请日：2013-04-17
发明人： Samir Kumar Roy , Saravanakumar Iyappan , Saju Varghese , Aparna Devi Addala , Milky Agarwal , Kanumuru Rahul Raju , Banibrata Pandey
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
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公开(公告)号：US20150344865A1
公开(公告)日：2015-12-03
申请号：US14655035
申请日：2013-04-17
发明人： Samir Kumar Roy , Saravanakumar Iyappan , Saju Varghese , Aparna Devi Addala , Milky Agarwal , Kanumuru Rahul Raju , Banibrata Pandey
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
摘要翻译： 本发明涉及编码蔗糖异构酶和异麦芽酮糖合成酶的天然基因的遗传修饰，以显着增加这些酶的表达水平，并且在生产稀有二糖如异麦芽酮糖和海藻糖的方法中使用所述酶。 本发明还公开了包含修饰基因的表达构建体和表达该基因的宿主细胞。
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