公开(公告)号：US6127177A

公开(公告)日：2000-10-03

申请号：US151821

申请日：1998-09-11

申请人： Mehmet Toner ,  Michael Russo ,  Robert Bieganski

发明人： Mehmet Toner ,  Michael Russo ,  Robert Bieganski

IPC分类号： A01N1/02 ,  C12N5/00

CPC分类号： A01N1/0221 ,  A01N1/02 ,  Y10S977/902 ,  Y10S977/92 ,  Y10S977/944

摘要： A preservation method for biological material having cell membranes includes reversibly porating the cell membranes; loading a bio-protective agent having bio-preservation properties to a predetermined intracellular concentration; preparing the bio-protective agent loaded biological material for storage; storing the biological material; recovering the stored biological material from storage; and reversing the cell membrane poration. H5 .alpha.-toxin, a genetically engineered mutant of Staphylococcus aureus .alpha.-hemolysin, may be used as a porating agent. Non-permeating sugars such as trehalose and sucrose may be used as the bio-protective agent.

摘要翻译： 具有细胞膜的生物材料的保存方法包括可逆地将细胞膜打孔; 将具有生物保存性能的生物保护剂装载到预定的细胞内浓度; 制备装载生物保护剂的生物材料进行储存; 储存生物材料; 从储存中回收储存的生物材料; 并逆转细胞膜引诱。 H5α-毒素，金黄色葡萄球菌α-溶血素的遗传工程改造的突变体，可用作开孔剂。 可以使用非渗透性糖如海藻糖和蔗糖作为生物保护剂。

公开(公告)号：US06902931B1

公开(公告)日：2005-06-07

申请号：US09443842

申请日：1999-11-19

申请人： Mehmet Toner ,  Michael Russo ,  Robert Bieganski

发明人： Mehmet Toner ,  Michael Russo ,  Robert Bieganski

IPC分类号： A01N1/02 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08

CPC分类号： A01N1/0221 ,  A01N1/02 ,  Y10S977/902 ,  Y10S977/92 ,  Y10S977/944

摘要： A preservation method for biological material having cell membranes includes reversibly porating the cell membranes; loading a bio-protective agent having bio-preservation properties to a predetermined intracellular concentration; preparing the bio-protective agent loaded biological material for storage; storing the biological material; recovering the stored biological material from storage; and reversing the cell membrane poration. H5 α-toxin, a genetically engineered mutant of Staphylococcus aureus α-hemolysin, may be used as a porating agent. Non-permeating sugars such as trehalose and sucrose may be used as the bio-protective agent.

摘要翻译： 具有细胞膜的生物材料的保存方法包括可逆地将细胞膜打孔; 将具有生物保存性能的生物保护剂装载到预定的细胞内浓度; 制备装载生物保护剂的生物材料进行储存; 储存生物材料; 从储存中回收储存的生物材料; 并逆转细胞膜引诱。 H5α-毒素，金黄色葡萄球菌α-溶血素的遗传工程改造的突变体可用作开孔剂。 可以使用非渗透性糖如海藻糖和蔗糖作为生物保护剂。

公开(公告)号：US06640137B2

公开(公告)日：2003-10-28

申请号：US10098821

申请日：2002-03-15

申请人： Stuart G. MacDonald

发明人： Stuart G. MacDonald

IPC分类号： A61N108

CPC分类号： A61N1/3785 ,  A61N1/3708 ,  A61N1/3718 ,  H02N11/002 ,  Y10S977/882 ,  Y10S977/944

摘要： An implantable, rechargeable assembly that contains an implantable device within a living organism; an electrical storage device is connected to the implantable device, and a thermoelectric charging assembly is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module, for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

摘要翻译： 一种植入式可充电组件，其包含活体内的可植入装置; 电存储装置连接到可植入装置，并且热电充电组件连接到所述蓄电装置。 热电充电组件包括用于在活体和热电模块之间传递热能的装置，用于从热能产生具有第一极性的电流，用于从热能产生具有第二极性的电流，用于对电存储充电 装置，其具有所述第一极性的电流，并且用第二极性的电流对蓄电装置充电。

公开(公告)号：US06656763B1

公开(公告)日：2003-12-02

申请号：US10385375

申请日：2003-03-10

申请人： Jane V. Oglesby ,  Christopher F. Lyons ,  Ramkumar Subramanian ,  Angela T. Hui ,  Minh Van Ngo ,  Suzette K. Pangrle

发明人： Jane V. Oglesby ,  Christopher F. Lyons ,  Ramkumar Subramanian ,  Angela T. Hui ,  Minh Van Ngo ,  Suzette K. Pangrle

IPC分类号： H01L5140

CPC分类号： G11C13/025 ,  B82Y10/00 ,  G11C11/5664 ,  G11C13/0014 ,  G11C13/0016 ,  G11C2213/16 ,  G11C2213/71 ,  H01L27/285 ,  H01L51/0003 ,  H01L51/0004 ,  H01L51/0034 ,  H01L51/0035 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0038 ,  H01L51/0041 ,  H01L51/005 ,  H01L51/0053 ,  H01L51/0059 ,  H01L51/0062 ,  H01L51/0077 ,  H01L51/0078 ,  H01L51/0081 ,  H01L51/0084 ,  H01L51/0085 ,  Y10S977/843 ,  Y10S977/944

摘要： A method of making organic memory cells made of two electrodes with a controllably conductivce media between the two electrodes is disclosed. The controllably conductive media contains an organic semiconductor layer and passive layer. The organic semiconductor layer is formed using spin-on techniques with the assistance of certain solvents.

摘要翻译： 公开了一种在两个电极之间制造具有可控导电介质的两个电极制成的有机存储单元的方法。 可控导电介质包含有机半导体层和无源层。 在某些溶剂的帮助下，使用旋转技术形成有机半导体层。

公开(公告)号：US20030176900A1

公开(公告)日：2003-09-18

申请号：US10098821

申请日：2002-03-15

发明人： Stuart G. MacDonald

IPC分类号： A61N001/08

CPC分类号： A61N1/3785 ,  A61N1/3708 ,  A61N1/3718 ,  H02N11/002 ,  Y10S977/882 ,  Y10S977/944

摘要： An implantable, rechargeable assembly that contains an implantable device within a living organism; an electrical storage device is connected to the implantable device, and a thermoelectric charging assembly is connected to said electrical storage device. A thermoelectric charging assembly contains devices for transferring thermal energy between the living organism and a thermoelectric module, for creating an electrical current of a first polarity from thermal energy, for creating an electrical current with a second polarity from thermal energy, for charging the electrical storage device with the electrical current of said first polarity, and for charging the electrical storage device with the electrical current of the second polarity.

摘要翻译： 一种植入式可充电组件，其包含活体内的可植入装置; 电存储装置连接到可植入装置，并且热电充电组件连接到所述蓄电装置。 热电充电组件包括用于在活体和热电模块之间传递热能的装置，用于从热能产生具有第一极性的电流，用于从热能产生具有第二极性的电流，用于对电存储充电 装置，其具有所述第一极性的电流，并且用第二极性的电流对蓄电装置充电。