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    BIOMEDICAL PATCHES WITH ALIGNED FIBERS
    2.
    发明申请
    BIOMEDICAL PATCHES WITH ALIGNED FIBERS 有权

    公开(公告)号：US20230053327A9

    公开(公告)日：2023-02-16

    申请号：US17358463

    申请日：2021-06-25

    申请人： Washington University

    发明人： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

    IPC分类号： A61F2/02 ,  B29C48/14 ,  D01D5/00 ,  D04H1/728 ,  D04H3/016 ,  D04H3/073 ,  A61F2/10 ,  A61L15/22 ,  A61L15/42 ,  A61F2/00 ,  A61L27/50 ,  B29C48/05 ,  A61L27/14 ,  C12M1/12

    摘要： A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

    System for stimulating bone growth, tissue healing and/or pain control, and method of use
    3.
    发明授权
    System for stimulating bone growth, tissue healing and/or pain control, and method of use 有权

    公开(公告)号：US10363412B2

    公开(公告)日：2019-07-30

    申请号：US15807152

    申请日：2017-11-08

    申请人： Washington University

    发明人： Eric Claude Leuthardt ,  Daniel W. Moran ,  Matthew R. MacEwan

    IPC分类号： A61N1/05 ,  A61N1/20 ,  A61N1/32 ,  A61N1/36 ,  A61B17/70

    摘要： A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

    Biomedical patches with aligned fibers
    6.
    发明授权
    Biomedical patches with aligned fibers 有权

    公开(公告)号：US11096772B1

    公开(公告)日：2021-08-24

    申请号：US17229171

    申请日：2021-04-13

    申请人： Washington University

    发明人： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

    IPC分类号： A61F2/02 ,  A61L15/22 ,  A61L15/42 ,  A61L27/14 ,  A61L27/50 ,  D01D5/00 ,  D04H1/728 ,  D04H3/016 ,  D04H3/073 ,  C12M1/12

    摘要： A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

    BIOMEDICAL PATCHES WITH ALIGNED FIBERS
    8.
    发明申请
    BIOMEDICAL PATCHES WITH ALIGNED FIBERS 有权

    公开(公告)号：US20210030525A1

    公开(公告)日：2021-02-04

    申请号：US17063924

    申请日：2020-10-06

    申请人： Washington University

    发明人： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

    IPC分类号： A61F2/02 ,  B29C48/05 ,  B29C48/14 ,  A61L15/22 ,  A61L15/42 ,  A61L27/14 ,  A61L27/50 ,  D01D5/00 ,  D04H1/728 ,  D04H3/016 ,  D04H3/073

    摘要： A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

    BIOMEDICAL PATCHES WITH ALIGNED FIBERS
    9.
    发明申请
    BIOMEDICAL PATCHES WITH ALIGNED FIBERS 审中-公开

    公开(公告)号：US20190021837A1

    公开(公告)日：2019-01-24

    申请号：US16130005

    申请日：2018-09-13

    申请人： Washington University

    发明人： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

    IPC分类号： A61F2/02 ,  D04H3/073 ,  D04H3/016 ,  D04H1/728 ,  D01D5/00 ,  A61L15/42 ,  B29C47/00 ,  A61L27/50 ,  A61L27/14 ,  A61L15/22 ,  C12M1/12

    摘要： A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.