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公开(公告)号:US20020015722A1
公开(公告)日:2002-02-07
申请号:US09564662
申请日:2000-05-03
发明人: Leslie John Herzog , Sanitha Shamanna Bhima Rao , Matthew Richard Park , John David Crump , Charles Bee Brown , Podutoori Ravinder Reddy , Mandy Kim Chen , Matthew Patrick , Michael Budd
IPC分类号: A61K047/00 , A61K031/35 , A61K031/305
CPC分类号: A61K31/35 , A23F3/14 , A23F3/30 , A23F3/34 , A23F3/405 , A23L33/105 , A23L33/11 , A23V2002/00 , A61K31/305 , A61K2300/00 , A23V2250/214 , A23V2250/2116
摘要: A food product containing isoflavones and flavanol is taught, where the weight ratio of isoflavones to flavanol is from 10 to 1 to 1 to 100.
摘要翻译: 教导了含有异黄酮和黄烷醇的食品,其中异黄酮与黄烷醇的重量比为10至1至1至100。
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公开(公告)号:US20030225117A1
公开(公告)日:2003-12-04
申请号:US10418036
申请日:2003-04-17
发明人: Alvar Gronberg , Per Wikstrom
IPC分类号: C12Q001/54 , A61K031/44 , A61K031/4164 , A61K031/305 , A61K031/265 , A61K031/255
CPC分类号: A61K31/255 , A61K31/03 , A61K31/12 , A61K31/265 , A61K31/305 , A61K31/4164 , A61K31/44 , C12Q1/26 , G01N33/66 , G01N33/6893 , G01N2500/04 , G01N2800/042 , Y10S514/866
摘要: The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or diseases related thereto, such as type II diabetes. Specifically, the invention relates to a method for identifying an agent useful for the treatment or prophylaxis of a medical condition associated with elevated levels of blood glucose, the method comprising (i) contacting a candidate agent with a mammalian NAD(P)H oxidase or NAD(P)H oxidase complex; and (ii) determining whether said candidate agent inhibits the biological activities of the NAD(P)H oxidase or NAD(P)H oxidase complex.
摘要翻译: 本发明涉及NAD(P)H氧化酶抑制剂用于增加葡萄糖的细胞摄取以及用于治疗和/或预防由胰岛素抵抗或其相关疾病引起的疾病,例如II型糖尿病。 具体地,本发明涉及用于鉴定可用于治疗或预防与血糖水平升高相关的医学病症的药剂的方法,所述方法包括(i)使候选药剂与哺乳动物NAD(P)H氧化酶或 NAD(P)H氧化酶复合物; 和(ii)确定所述候选试剂是否抑制NAD(P)H氧化酶或NAD(P)H氧化酶复合物的生物活性。
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