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12 条记录 (耗时 0.02 秒)

    Methods of Detecting Prostate Cancer
    3.
    发明申请
    Methods of Detecting Prostate Cancer 审中-公开
    检测前列腺癌的方法

    公开(公告)号：US20080260637A1

    公开(公告)日：2008-10-23

    申请号：US11667793

    申请日：2005-11-16

    申请人： Dalia Dickman

    发明人： Dalia Dickman

    IPC分类号： A61K51/08 ,  C12Q1/04 ,  C12Q1/16 ,  A61K103/32 ,  A61K103/20 ,  A61K101/00 ,  A61K103/00 ,  A61K103/30 ,  A61K103/10 ,  C12Q1/68

    CPC分类号： G01N33/57434 ,  A61K51/0476 ,  G01N33/60

    摘要： A method of detecting presence or absence of prostate cancer in a subject, both in vivo and ex vivo is disclosed. The method comprises analyzing mitochondria or a mitochondrial component in at least one prostate cell of the subject, whereby mitochondria an alteration in quantity and or characteristic is indicative of the presence or absence of the prostate cancer in the subject.

    摘要翻译： 公开了一种在体内和体内检测受试者中存在或不存在前列腺癌的方法。 该方法包括分析受试者的至少一个前列腺细胞中的线粒体或线粒体成分，由此线粒体数量和/或特征的改变指示受试者中前列腺癌的存在或不存在。

    LIVER- RECEPTOR IMAGING INJECTION, DISPENSING METHOD AND PHARMACEUTICAL COMPOSITION THEREOF
    4.
    发明申请
    LIVER- RECEPTOR IMAGING INJECTION, DISPENSING METHOD AND PHARMACEUTICAL COMPOSITION THEREOF 有权
    肝脏摄取成像注射，分配方法及其药物组合物

    公开(公告)号：US20120107236A1

    公开(公告)日：2012-05-03

    申请号：US13243225

    申请日：2011-09-23

    申请人： MEI-HUI WANG ,  Wuu-Jyh Lin ,  Hung-Man Yu ,  Chuan-Yi Chien ,  Ping-Yen Wang

    发明人： MEI-HUI WANG ,  Wuu-Jyh Lin ,  Hung-Man Yu ,  Chuan-Yi Chien ,  Ping-Yen Wang

    IPC分类号： A61K103/20 ,  C07F5/00 ,  A61P43/00

    CPC分类号： A61K51/0491 ,  A61K51/0406 ,  A61K51/0497 ,  A61K51/065

    摘要： The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.

    摘要翻译： 本发明涉及一种肝 - 受体成像注射用药物组合物，该药物组合物包含具有ASGPR特异性的双功能化合物，其中双官能化合物包括α-氨基酸（或其衍生物 ）和与α-氨基酸连接的聚半乳糖胺链（或聚乳糖链）。 因此，药物组合物可以量化肝脏储存能力的潜力并评估肝脏疾病过程的严重程度。 还提供使用其的肝受体成像注射器及其一步式分配方法，以改善碘标记的缺陷，克服降压标记产率和高压灭菌后的不稳定性的缺点。

    Toxins and radionuclides coupled to IGF-1 receptor ligands for treatment of cancer
    7.
    发明申请
    Toxins and radionuclides coupled to IGF-1 receptor ligands for treatment of cancer 有权
    与IGF-1受体配体偶联的毒素和放射性核素用于治疗癌症

    公开(公告)号：US20070224119A1

    公开(公告)日：2007-09-27

    申请号：US11788627

    申请日：2007-04-20

    申请人： Hugh McTavish

    发明人： Hugh McTavish

    IPC分类号： A61K51/08 ,  A61K103/10 ,  A61K103/20 ,  A61P43/00 ,  A61K103/32 ,  A61K38/30

    CPC分类号： A61K38/30 ,  A61K47/62 ,  A61K47/64 ,  A61K47/6415 ,  A61K51/088

    摘要： The invention provides an insulin-like growth factor-1 (IGF-1) receptor ligand carrying a therapeutic radionuclide for treatment of cancer is provided. A method of treating cancer using the IGF-1 receptor ligand carrying a therapeutic radionuclide is also provided. An anti-cancer therapeutic agent containing an IGF-1 receptor ligand linked to a toxin is also provided, as are methods of using the toxin conjugates for treatment of cancer.

    摘要翻译： 本发明提供了一种携带用于治疗癌症的治疗放射性核素的胰岛素样生长因子-1（IGF-1）受体配体。 还提供了使用携带治疗性放射性核素的IGF-1受体配体治疗癌症的方法。 还提供了含有与毒素连接的IGF-1受体配体的抗癌治疗剂，以及使用毒素缀合物治疗癌症的方法。

    Chelating Agent Conjugated Alpha-MSH Peptide Derivatives, Preparation Method Thereof and Composition for Diagnosis and Treatment of Melanoma Comprising the Same as an Active Ingredient
    9.
    发明申请
    Chelating Agent Conjugated Alpha-MSH Peptide Derivatives, Preparation Method Thereof and Composition for Diagnosis and Treatment of Melanoma Comprising the Same as an Active Ingredient 有权
    螯合剂缀合的α-MSH肽衍生物及其制备方法和用于诊断和治疗与活性成分相同的黑素瘤的组合物

    公开(公告)号：US20090304586A1

    公开(公告)日：2009-12-10

    申请号：US12409288

    申请日：2009-03-23

    申请人： Young-Don Hong ,  Sun-Ju Choi ,  So-Young Lee ,  Kang-Hyuk Choi

    发明人： Young-Don Hong ,  Sun-Ju Choi ,  So-Young Lee ,  Kang-Hyuk Choi

    IPC分类号： A61K51/08 ,  C07K7/00 ,  A61K103/32 ,  A61K103/10 ,  A61K103/20 ,  A61K103/00

    CPC分类号： C07K14/685 ,  A61K51/086 ,  A61K51/088

    摘要： Disclosed are chelating agent-conjugated α-MSH peptide derivatives, preparation methods thereof, and compositions for use in a diagnosis or treatment of a melanoma tumor containing the same as an active ingredient. The novel α-MSH peptide derivatives conjugated with chelating agent according to the present invention are highly selective to the melanocortin-1 receptor which is α-MSH receptor expressing in melanoma tumor and their labeling rate of a radioactive isotope is high. Also, they remain in kidney shortly and have high taking rate of the melanoma tumor. Therefore, with the aforesaid reasons, they may be effectively used for early diagnosis or treatment of melanoma tumor.

    摘要翻译： 公开了螯合剂缀合的α-MSH肽衍生物，其制备方法和用于诊断或治疗含有其作为活性成分的黑素瘤肿瘤的组合物。 与根据本发明的螯合剂缀合的新型α-MSH肽衍生物对黑皮质素-1受体具有高度选择性，黑素皮质素-1受体是黑素瘤肿瘤中表达的α-MSH受体，并且其放射性同位素的标记率高。 此外，他们很快就保持在肾脏，并且具有高的黑色素瘤肿瘤的摄入率。 因此，由于上述原因，它们可以有效地用于黑色素瘤肿瘤的早期诊断或治疗。

    Carrier molecules
    10.
    发明申请
    Carrier molecules 审中-公开
    载体分子

    公开(公告)号：US20090092546A1

    公开(公告)日：2009-04-09

    申请号：US12231381

    申请日：2008-09-02

    申请人： Francis J. Carr ,  Anita A. Hamilton

    发明人： Francis J. Carr ,  Anita A. Hamilton

    IPC分类号： A61K51/10 ,  C07K16/18 ,  A61K101/02 ,  A61K103/10 ,  A61K103/20 ,  A61K101/00 ,  A61K103/34

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56

    摘要： The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.

    摘要翻译： 本发明一般涉及一种衍生自一种动物或禽类物种或菌株的载体分子，当从另一种动物或禽类生物的物种或毒株暴露于免疫系统时，它们基本上是非免疫原性的。 更具体地，本发明提供了用于诊断和治疗应用的去免疫化免疫相互作用分子和甚至更特定的去免疫化抗体。