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公开(公告)号：US20100216696A1
公开(公告)日：2010-08-26
申请号：US12661356
申请日：2010-03-16
Applicant: Hugh McTavish
Inventor： Hugh McTavish
CPC classification number: C07K14/65
Abstract: The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent.
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公开(公告)号：US20100197890A1
公开(公告)日：2010-08-05
申请号：US12657906
申请日：2010-01-29
Applicant: Hugh McTavish
Inventor： Hugh McTavish
CPC classification number: A61K47/64
Abstract: The invention provides polypeptide-platinum conjugates comprising an anti-cancer platinum complex conjugated to polypeptides that bind relatively specifically to cancer cells, so as to direct the conjugates to cancer cells resulting in increased anti-cancer efficacy and decreased side-effects as compared to cisplatin and other conventional anti-cancer platinum complexes.
Abstract translation: 本发明提供了多肽 - 铂共轭物，其包含缀合到与癌细胞相对特异性结合的多肽的抗癌铂络合物，以便与顺铂相比，将结合物引导至癌细胞，导致增加的抗癌功效和降低的副作用 和其他常规的抗癌铂络合物。
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公开(公告)号：US07608439B2
公开(公告)日：2009-10-27
申请号：US11821935
申请日：2007-06-26
Applicant: Hugh McTavish , John D. Offerman
Inventor： Hugh McTavish , John D. Offerman
CPC classification number: C12P5/023 , Y02E50/17 , Y02E50/343
Abstract: The invention provides a method to decrease emission of carbon dioxide from combustion of fossil fuels or other hydrocarbons and to enhance the efficiency of methane production from anaerobic biodigesters. The invention involves feeding carbon dioxide from the exhaust gas of hydrocarbon fuel combustion to an anaerobic biodigester where biomass is anaerobically fermented to produce methane. Carbon dioxide is an electron acceptor for anaerobic fermentation, and thus some of the carbon dioxide is reduced to methane, which can again be used for fuel. In this way, at least a portion of the exhaust gas CO2 is recycled to form fuel methane instead of being released into the atmosphere. Thus, the net CO2 emission from burning a given amount of fossil fuel is decreased. Adding carbon dioxide to an anaerobic fermentation also increases the efficiency and amount of methane production in the fermentation.
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公开(公告)号：US20080026443A1
公开(公告)日：2008-01-31
申请号：US11906396
申请日：2007-10-02
Applicant: John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
Inventor： John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
CPC classification number: C02F3/346 , C02F11/04 , C07C27/22 , C07C29/1518 , C12M21/04 , C12M43/00 , C12P5/023 , C12P7/04 , C12P7/08 , Y02E50/16 , Y02E50/17 , Y02E50/32 , Y02E50/343 , Y02W10/23 , C07C31/04 , C07C31/12 , C07C31/125 , C07C31/10 , C07C31/08
Abstract: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of the synthesis gas with a catalyst to produce alcohol. In some embodiments, a microorganism that reduces ferric iron to ferrous iron is included in the fermentation mixture to enhance the efficiency of the fermentation and the yield of alcohol. The invention also provides a method of producing alcohol involving fermenting organic material to a biogas comprising methane; removing sulfhydryls from the biogas; converting at least a portion of the biogas to synthesis gas comprising CO and H2; contacting at least a portion of the synthesis gas with a sulfur-free catalyst to produce a substantially sulfur-free alcohol; and purifying the alcohol wherein the purified alcohol is substantially sulfur-free and comprises less than 5% methanol and at least 70% C2+ alcohols by weight.
Abstract translation: 本发明提供用于生产乙醇和其它醇的方法，装置和试剂盒。 所述方法包括将发酵混合物中的有机材料发酵成包含甲烷的沼气; 将至少一部分沼气转化成包含CO和H 2的合成气; 并使至少一部分合成气与催化剂接触以产生醇。 在一些实施方案中，将发酵混合物中包含将铁还原成二价铁的微生物，以提高发酵的效率和醇的产率。 本发明还提供一种生产醇的方法，其涉及将有机材料发酵成包含甲烷的沼气; 从沼气中除去巯基; 将至少一部分沼气转化成包含CO和H 2的合成气; 使至少一部分合成气与无硫催化剂接触以产生基本上不含硫的醇; 并纯化醇，其中纯化醇基本上是无硫的，并且包含小于5重量％的甲醇和至少70重量％的C 2醇。
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5.发明申请Toxins and radionuclides coupled to IGF-1 receptor ligands for treatment of cancer 有权与IGF-1受体配体偶联的毒素和放射性核素用于治疗癌症公开(公告)号：US20070224119A1
公开(公告)日：2007-09-27
申请号：US11788627
申请日：2007-04-20
Applicant: Hugh McTavish
Inventor： Hugh McTavish
IPC: A61K51/08 , A61K103/10 , A61K103/20 , A61P43/00 , A61K103/32 , A61K38/30
CPC classification number: A61K38/30 , A61K47/62 , A61K47/64 , A61K47/6415 , A61K51/088
Abstract: The invention provides an insulin-like growth factor-1 (IGF-1) receptor ligand carrying a therapeutic radionuclide for treatment of cancer is provided. A method of treating cancer using the IGF-1 receptor ligand carrying a therapeutic radionuclide is also provided. An anti-cancer therapeutic agent containing an IGF-1 receptor ligand linked to a toxin is also provided, as are methods of using the toxin conjugates for treatment of cancer.
Abstract translation: 本发明提供了一种携带用于治疗癌症的治疗放射性核素的胰岛素样生长因子-1（IGF-1）受体配体。 还提供了使用携带治疗性放射性核素的IGF-1受体配体治疗癌症的方法。 还提供了含有与毒素连接的IGF-1受体配体的抗癌治疗剂，以及使用毒素缀合物治疗癌症的方法。
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Patent Agency Ranking
公开(公告)号：US20100303929A1
公开(公告)日：2010-12-02
申请号：US12803526
申请日：2010-06-29
Applicant: Hugh McTavish
Inventor： Hugh McTavish
Abstract: The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent.
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公开(公告)号：US20080227571A1
公开(公告)日：2008-09-18
申请号：US12009642
申请日：2008-01-19
Applicant: Hugh McTavish , Johannes N. Gaston , Douglas J. VanOrnum , Brian D. Gale , Steven A. Beaudry
Inventor： Hugh McTavish , Johannes N. Gaston , Douglas J. VanOrnum , Brian D. Gale , Steven A. Beaudry
IPC: A63B69/38
CPC classification number: A63B69/0097 , A63B69/38 , A63B2071/026 , A63B2209/00 , A63B2210/50
Abstract: The invention provides a new tennis backboard design. The backboard includes a firm backing layer underlying a soft deadening layer. The rebound of a tennis ball from the backboard is reduced as compared to rebound from a rigid hard-surface backboard. This allows a player to stand fairly close to the backboard, which reduces misses. The player can stand fairly close and hit balls hard against the backboard. Because the rebound is reduced, the ball simply bounces back softly and easily to the player, allowing the player to hit hard again from a fairly short distance. Thus, long rallies without missing are easily achieved. Since the bounce is reduced, the player can stand closer to the backboard, and therefore the backboard can be smaller than conventional backboards without the player missing the backboard. This allows the backboard to be light, portable, and easily stored. Because of the addition of a soft deadening layer, the firm backing layer of the backboard can also be thin and made of lighter and weaker material than a conventional backboard, reducing the weight of the backboard.
Abstract translation: 本发明提供了一种新的网球背板设计。 背板包括柔软的消音层下面的坚固背衬层。 与刚性硬表面背板的回弹相比，网球从背板的反弹减少了。 这样一来，玩家就可以靠近篮板，这样可以减少错误。 玩家可以相当接近，并且撞击篮板。 因为反弹减少，球轻轻地弹回到玩家身上，让玩家从相当短的距离再次击中。 因此，很容易就能实现没有失误的长期集会。 由于反弹减少，玩家可以靠近背板，因此背板可以比常规背板小，而玩家缺少背板。 这样就可以使背板轻巧，便于携带，方便存放。 由于添加了柔软的减震层，背板的坚固背衬层也可以比传统背板更薄，材质更轻，材质更薄，从而减轻了背板的重量。
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公开(公告)号：US20080032394A1
公开(公告)日：2008-02-07
申请号：US11906518
申请日：2007-10-02
Applicant: John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
Inventor： John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
IPC: C12M1/107
CPC classification number: C02F3/346 , C02F11/04 , C07C27/22 , C07C29/1518 , C12M21/04 , C12M43/00 , C12P5/023 , C12P7/04 , C12P7/08 , Y02E50/16 , Y02E50/17 , Y02E50/32 , Y02E50/343 , Y02W10/23 , C07C31/04 , C07C31/12 , C07C31/125 , C07C31/10 , C07C31/08
Abstract: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of the synthesis gas with a catalyst to produce alcohol. In some embodiments, a microorganism that reduces ferric iron to ferrous iron is included in the fermentation mixture to enhance the efficiency of the fermentation and the yield of alcohol. The invention also provides a method of producing alcohol involving fermenting organic material to a biogas comprising methane; removing sulfhydryls from the biogas; converting at least a portion of the biogas to synthesis gas comprising CO and H2; contacting at least a portion of the synthesis gas with a sulfur-free catalyst to produce a substantially sulfur-free alcohol; and purifying the alcohol wherein the purified alcohol is substantially sulfur-free and comprises less than 5% methanol and at least 70% C2+ alcohols by weight.
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公开(公告)号：US20050266540A1
公开(公告)日：2005-12-01
申请号：US11137874
申请日：2005-05-26
Applicant: John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
Inventor： John Offerman , Delman Hogen , Jeffrey Lighthart , Hugh McTavish
IPC: C02F3/12 , C02F3/28 , C02F3/34 , C02F11/04 , C07C27/22 , C07C27/26 , C07C29/151 , C12P5/02 , C12P7/04 , C12P7/06 , C12P7/08
CPC classification number: C02F3/346 , C02F11/04 , C07C27/22 , C07C29/1518 , C12M21/04 , C12M43/00 , C12P5/023 , C12P7/04 , C12P7/08 , Y02E50/16 , Y02E50/17 , Y02E50/32 , Y02E50/343 , Y02W10/23 , C07C31/04 , C07C31/12 , C07C31/125 , C07C31/10 , C07C31/08
Abstract: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of the synthesis gas with a catalyst to produce alcohol. In some embodiments, a microorganism that reduces ferric iron to ferrous iron is included in the fermentation mixture to enhance the efficiency of the fermentation and the yield of alcohol. The invention also provides a method of producing alcohol involving fermenting organic material to a biogas comprising methane; removing sulfhydryls from the biogas; converting at least a portion of the biogas to synthesis gas comprising CO and H2; contacting at least a portion of the synthesis gas with a sulfur-free catalyst to produce a substantially sulfur-free alcohol; and purifying the alcohol wherein the purified alcohol is substantially sulfur-free and comprises less than 5% methanol and at least 70% C2+ alcohols by weight.
Abstract translation: 本发明提供用于生产乙醇和其它醇的方法，装置和试剂盒。 所述方法包括将发酵混合物中的有机材料发酵成包含甲烷的沼气; 将至少一部分沼气转化成包含CO和H 2的合成气; 并使至少一部分合成气与催化剂接触以产生醇。 在一些实施方案中，将发酵混合物中包含将铁还原成二价铁的微生物，以提高发酵的效率和醇的产率。 本发明还提供一种生产醇的方法，其涉及将有机材料发酵成包含甲烷的沼气; 从沼气中除去巯基; 将至少一部分沼气转化成包含CO和H 2的合成气; 使至少一部分合成气与无硫催化剂接触以产生基本上不含硫的醇; 并纯化醇，其中纯化醇基本上是无硫的，并且包含小于5重量％的甲醇和至少70重量％的C 2醇。
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10.发明申请Fusion Proteins Containing Insulin-Like Growth Factor-1 and Epidermal Growth Factor and Variants Thereof and Uses Thereof 有权含有胰岛素样生长因子-1和表皮生长因子及其变体的融合蛋白及其用途公开(公告)号：US20150196656A1
公开(公告)日：2015-07-16
申请号：US14594980
申请日：2015-01-12
Applicant: Hugh McTavish
Inventor： Hugh McTavish
IPC: A61K47/48 , A61K31/4184 , A61K38/19 , A61K31/519
CPC classification number: A61K38/191 , A61K31/196 , A61K31/4184 , A61K31/519 , A61K38/00 , A61K47/642 , A61K51/08 , C07K14/485 , C07K14/495 , C07K14/52 , C07K14/525 , C07K14/65 , C07K2319/02 , C07K2319/21
Abstract: Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (IGF-1) and variants thereof, epidermal growth factor (EGF), and other ligands to the EGF receptor, are provided. The fusion proteins further comprise SEQ ID NO:1 or other segments having lysine, glutamic acid, or aspartic acid residues. Uses for the fusion proteins are also provided.
Abstract translation: 提供了包含细胞因子，特别是胰岛素样生长因子-1（IGF-1）及其变体，表皮生长因子（EGF）以及EGF受体的其它配体的融合蛋白。 融合蛋白还包含SEQ ID NO：1或具有赖氨酸，谷氨酸或天冬氨酸残基的其它区段。 还提供了融合蛋白的用途。
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