公开(公告)号：US06539265B2

公开(公告)日：2003-03-25

申请号：US09848487

申请日：2001-05-03

申请人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

发明人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

IPC分类号： A61N106

CPC分类号： A61N1/3702 ,  A61B5/0424 ,  A61B5/044 ,  A61B5/1107 ,  A61B18/1492 ,  A61B2018/1435 ,  A61B2018/144 ,  A61B2018/1472

摘要： The present invention provides an apparatus method for performing rf intraluminal reduction and/or occlusion with a virtual electrode. An apparatus in accord with the present invention includes a catheter and a guide wire. The guide wire includes a conductive core having a proximal end electrically connected to a generator of rf current and an exposed distal end. An insulative material having disposed therein at least one microlumen for providing a conductive fluid to a target site within the lumen encases the guide wire.

摘要翻译： 本发明提供一种用虚拟电极进行腔内还原和/或闭塞的装置方法。 根据本发明的装置包括导管和导丝。 导丝包括导电芯，其具有电连接到rf电流的发生器和暴露的远端的近端。 在其中设置有用于将导电流体提供到管腔内的目标部位的至少一个微粉末的绝缘材料包围导丝。

公开(公告)号：US06327505B1

公开(公告)日：2001-12-04

申请号：US09304681

申请日：1999-05-04

申请人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

发明人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

IPC分类号： A61N106

CPC分类号： A61N1/3702 ,  A61B5/0424 ,  A61B5/044 ,  A61B5/1107 ,  A61B18/1492 ,  A61B2018/1435 ,  A61B2018/144 ,  A61B2018/1472

摘要： The present invention provides an apparatus and method for performing rf intraluminal reduction and/or occlusion with a virtual electrode. An apparatus in accord with the present invention includes a catheter and a guide wire. The guide wire includes a conductive core having a proximal end electrically connected to a generator of rf current and an exposed distal end. An insulative material having disposed therein at least one microlumen for providing a conductive fluid to a target site within the lumen encases the guide wire. In a method in accord with the present invention, an rf conductive fluid is introduced at the target site in a body lumen. Radio frequency current is applied to the site by a conductive electrode through the conductive fluid, causing the connective tissues in the lumen walls to heat and contract. Application of the rf current is discontinued when the lumen wall has contracted or been reduced to the desired extent, which will often be complete occlusion.

摘要翻译： 本发明提供一种用虚拟电极进行腔内还原和/或闭塞的装置和方法。 根据本发明的装置包括导管和导丝。 导丝包括导电芯，其具有电连接到rf电流的发生器和暴露的远端的近端。 在其中设置有用于将导电流体提供到管腔内的目标部位的至少一个微粉末的绝缘材料包围导丝。 在根据本发明的方法中，将rf导电流体引入体腔内的靶部位。 射频电流通过导电流体通过导电电极施加到现场，导致管腔壁中的结缔组织发热和收缩。 当管腔壁收缩或减小至所需程度时，rf电流的应用停止，这通常是完全闭塞的。

公开(公告)号：US06527697B2

公开(公告)日：2003-03-04

申请号：US09740839

申请日：2000-12-21

申请人： Grant Ernest Bashford ,  Edward Paul Gerard Wessler ,  Raymond Macklin Whitton

发明人： Grant Ernest Bashford ,  Edward Paul Gerard Wessler ,  Raymond Macklin Whitton

IPC分类号： A61N106

CPC分类号： A61N2/02 ,  Y10S977/865

摘要： A therapeutic device and the use of it to alleviate the symptoms of health-related disorders. The device includes a magnetic field generator capable of creating a magnetic field, a power supply for providing power to energize the generator to generate a generated magnetic field, and a controller coupled to the power source for varying the power provided by the power supply to the generator. A method of alleviating the symptoms of a health-related disorder includes the steps of determining the direction and strength of the predominant component of a local magnetic field, generating a first magnetic field within a zone, wherein the first magnetic field is opposite in direction to the predominant component, wherein the first magnetic field is of sufficient strength such that within the zone the resulting field is between approximately 10,000 nT and 30,000 nT or between approximately −10,000 nT and −30,000 nT (or of sufficient strength to provide therapeutic value) and positioning an individual having health-related disorder symptoms substantially within the zone for a period of time sufficient to alleviate the symptoms.

摘要翻译： 治疗装置及其用于缓解健康相关疾病症状的用途。 该装置包括能够产生磁场的磁场发生器，用于提供功率以激励发电机以产生产生的磁场的电源，以及耦合到电源的控制器，用于将由电源提供的电力改变为 发电机。 减轻健康相关疾病症状的方法包括以下步骤：确定局部磁场的主要成分的方向和强度，在区域内产生第一磁场，其中第一磁场在 主要组分，其中第一磁场具有足够的强度，使得在该区域内，所得场在约10,000nT至30,000nT之间或约-10,000nT至-30,000nT（或具有足够的强度以提供治疗值）和 将具有健康相关障碍症状的个体定位在该区域内基本上在足以减轻症状的时间段内。

公开(公告)号：US06430447B1

公开(公告)日：2002-08-06

申请号：US09707706

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

摘要翻译： 用于直接接触人心内膜的可植入刺激电极显示小于约0.3mV的低偏振值，并且旨在用于具有耦合到导体的近端的电连接器的可植入导线，用于可释放地附接到刺激 脉冲发生器。 电极由具有初始暴露的外表面的金属基底构成，其基本上覆盖有第一内层氮化钛和第二外层铂黑。 氮化钛的第一内层具有小于约15微米的厚度，并且类似地覆盖在氮化钛层上的第二外层铂黑的厚度小于约15微米。 本发明包括制造可植入刺激电极的方法。

公开(公告)号：US06356790B1

公开(公告)日：2002-03-12

申请号：US09361444

申请日：1999-07-26

申请人： Mark A. Maguire ,  Kevin C. Ladd ,  John W. Gaiser ,  Le T. Le

发明人： Mark A. Maguire ,  Kevin C. Ladd ,  John W. Gaiser ,  Le T. Le

IPC分类号： A61N106

CPC分类号： A61M25/0138 ,  A61B5/0422 ,  A61B5/6855 ,  A61B5/6857 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2017/00101 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00916 ,  A61B2018/1226 ,  A61B2018/124 ,  A61B2018/1273 ,  A61B2018/1861 ,  A61B2562/0209 ,  A61B2562/043 ,  A61M25/0147 ,  A61M2025/015 ,  A61M2025/0161

摘要： An improved system and method for ablating a tissue site is provided. In one embodiment, the system comprises an ablation catheter employing one or more electrodes and multiple temperature sensors located along the catheter distal end. The temperature sensors control the power applied to the one or more electrodes. A deflection mechanism may be included to provide directional control to the catheter.

摘要翻译： 提供了一种用于烧蚀组织部位的改进的系统和方法。 在一个实施例中，系统包括使用一个或多个电极的消融导管和沿着导管远端定位的多个温度传感器。 温度传感器控制施加到一个或多个电极的功率。 可以包括偏转机构以向导管提供方向控制。

公开(公告)号：US06687549B1

公开(公告)日：2004-02-03

申请号：US09911978

申请日：2001-07-25

申请人： John R. Helland ,  Kevin L. Morgan ,  Phong D. Doan

发明人： John R. Helland ,  Kevin L. Morgan ,  Phong D. Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable endocardial lead intended for use with a cardiac stimulation device includes an elongated lead body of flexible resilient material, for example, silicone rubber or polyurethane, having a longitudinally extending lumen defined by a plurality of longitudinally extending side wall surfaces, adjacent pairs of the side wall surfaces lying in angularly disposed planes and intersecting at an energy absorbing corner ridge. An electrical conductor is located loosely within and extends longitudinally along the lumen between proximal and distal ends. With this construction, forces imposed laterally on the lead body by the conductor engaging the side wall surfaces of the lumen upon bending of the lead body are absorbed without damaging the lead body by reason of engagement of the conductor with a corner ridge causing the corner ridge thereby engaged to recede toward a condition of being coplanar with its subtended pair of side wall surfaces.

摘要翻译： 旨在用于心脏刺激装置的可植入心内膜包括柔性弹性材料的细长引线体，例如硅橡胶或聚氨酯，具有由多个纵向延伸的侧壁表面限定的纵向延伸的内腔，相邻的一对 侧壁表面位于角度设置的平面中并且在能量吸收拐角脊处相交。 电导体松散地位于内端之间并且在近端和远端之间沿内腔纵向延伸。 利用这种结构，通过在引线体弯曲时与内腔的侧壁表面接合的导体横向地施加的力被吸收，而不会因导体与导致角隅角的拐角接合而损坏引线体 从而接合到与其对置的一对侧壁表面共面的状态。

公开(公告)号：US06560487B1

公开(公告)日：2003-05-06

申请号：US09679557

申请日：2000-10-06

申请人： Michael B. McGraw ,  William A. Rux ,  William J. Carroll ,  Richard M. Terrell ,  Randy Alan Murphy

发明人： Michael B. McGraw ,  William A. Rux ,  William J. Carroll ,  Richard M. Terrell ,  Randy Alan Murphy

IPC分类号： A61N106

CPC分类号： A61N1/326 ,  A61N1/323

摘要： A multi-functional portable electro-medical device provides interferential current stimulation to promote bone growth. Two electrical signals are applied to a target area, each electrical signal being formed by a set of two electrode pads. A beat frequency is created at the location the signals intersect with each other. The beat frequency is the difference between the frequencies of the two signals and has an amplitude that is additive and greater than either signal alone. The depth of the interferential signal is increased by increasing the carrier frequency of the signals. The direction of the interferential signal shifts toward the signal having the lower amplitude. The electrical stimulation is used in combination with biologics to further increase bone growth.

摘要翻译： 多功能便携式电疗装置提供干扰电流刺激以促进骨骼生长。 两个电信号被施加到目标区域，每个电信号由一组两个电极焊盘形成。 在信号彼此相交的位置处产生拍频。 节拍频率是两个信号的频率之间的差异，并且具有相加且大于任一个信号的幅度。 通过增加信号的载波频率来增加干扰信号的深度。 干扰信号的方向向具有较低振幅的信号转移。 电刺激与生物制剂结合使用以进一步增加骨生长。

公开(公告)号：US06493589B1

公开(公告)日：2002-12-10

申请号：US09636573

申请日：2000-08-10

申请人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

发明人： Adel M. Medhkour ,  Michael F. Hoey ,  Peter M. J. Mulier

IPC分类号： A61N106

CPC分类号： A61N1/3702 ,  A61B5/0424 ,  A61B5/044 ,  A61B5/1107 ,  A61B18/1492 ,  A61B2018/00541 ,  A61B2018/1435 ,  A61B2018/144 ,  A61B2018/1472

摘要： Apparatuses and methods are disclosed for introducing a conductive fluid and delivering an electrical current to the fluid at a target site in a body lumen. The electrical current is delivered to the site by a conductive electrode through the conductive fluid, causing the tissues in the lumen walls, or peripheral to the lumen walls, to heat and contract. Application of the current can be discontinued when the lumen wall has contracted or been reduced to the desired extent, which will often be complete occlusion. Alternatively, the current can be applied until tissues peripheral to the lumen are effected.

摘要翻译： 公开了用于引入导电流体并将电流输送到体腔内的靶位置处的流体的装置和方法。 电流通过导电流体通过导电电极传送到现场，导致管腔壁中的组织或腔壁周围的组织加热和收缩。 当管腔壁缩小或缩小到期望的程度时，电流的施加可以停止，这通常是完全闭塞的。 或者，可以施加电流，直到进入管腔周围的组织。

公开(公告)号：US06430448B1

公开(公告)日：2002-08-06

申请号：US09707828

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

公开(公告)号：US06246914B1

公开(公告)日：2001-06-12

申请号：US09372484

申请日：1999-08-12

申请人： Alan de la Rama ,  Hosheng Tu ,  Cary Hata

发明人： Alan de la Rama ,  Hosheng Tu ,  Cary Hata

IPC分类号： A61N106

CPC分类号： A61N1/06

摘要： A flexible catheter shaft suitable for inserting into a body of a patient comprising a high torque transmission assembly of a slit tubular element that has either a plurality of slits or at least one continuously spiraling slit on said slit tubular element and has sufficient torque properties ensuring that a substantial fraction of the rotational and displacement forces provided along said flexible catheter shaft are translated to rotational and displacement forces at a distal end of said flexible catheter shaft.

摘要翻译： 适于插入患者体内的柔性导管轴，包括狭缝管状元件的高扭矩传递组件，狭缝管状元件在所述狭缝管状元件上具有多个狭缝或至少一个连续螺旋形狭缝，并具有足够的扭矩特性，确保 沿着所述柔性导管轴提供的旋转和移位力的很大一部分被转换为在所述柔性导管轴的远端处的旋转和移位力。