公开(公告)号：US06454811B1

公开(公告)日：2002-09-24

申请号：US09416346

申请日：1999-10-12

申请人： Jill K. Sherwood ,  Linda G. Griffith ,  Scott Brown

发明人： Jill K. Sherwood ,  Linda G. Griffith ,  Scott Brown

IPC分类号： A61P202

CPC分类号： A61L27/46 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/468 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30199 ,  A61F2002/30301 ,  A61F2002/30678 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/3093 ,  A61F2002/30952 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30971 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2230/0095 ,  A61F2240/001 ,  A61F2250/0014 ,  A61F2250/0023 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/56 ,  B29C64/165 ,  B29L2031/7532 ,  B33Y70/00 ,  B33Y80/00 ,  A61L27/58 ,  A61L27/54

摘要： Composite devices for tissue engineering are provided having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In various embodiments, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue. The devices are made in a continuous process that imparts structural integrity as well as a unique gradient of materials in the architecture. The gradient may relate to the materials, the macroarchitecture, the microarchitecture, the mechanical properties of the device, or several of these together. The devices disclosed herein typically are made using solid free form processes, especially three-dimensional printing process (3DP™). The device can be manufactured in a single continuous process such that the transition from one form of tissue regeneration scaffold and the other form of tissue regeneration scaffold have no “seams” and are not subject to differential swelling along an axis once the device is implanted into physiological fluid.

摘要翻译： 提供了用于组织工程的复合装置，其具有以下一种或多种的梯度：材料，宏结构，微结构或机械性质，其可用于选择或促进特定细胞类型附着在装置之前和/ 或植入后。 在各种实施方案中，梯度在由材料组成的区域或具有最适合于一种类型的组织的特性的区域中形成过渡区域到由材料构成的区域或具有适用于不同类型的组织的性质的区域。 这些设备是在连续的过程中制造的，在架构中赋予结构完整性以及唯一的材料梯度。 梯度可能与材料，宏建筑结构，微架构，设备的机械性能或其中几种有关。 本文公开的装置通常使用固体自由形式工艺，特别是三维印刷工艺（3DP TM）制成。 该装置可以在单个连续过程中制造，使得来自组织再生支架的一种形式的过渡和组织再生支架的另一种形式不存在“接缝”，并且一旦将该装置植入，就不会沿着轴发生不均匀的溶胀 生理液体