公开(公告)号：US20040247687A1

公开(公告)日：2004-12-09

申请号：US10489853

申请日：2004-03-23

申请人： ROEHM GMBH & CO. KG

发明人： Hans-Ulrich Petereit ,  Guenter Bergmann ,  Klaus Lehmann

IPC分类号： A61K009/50 ,  B29B009/00

CPC分类号： A61K9/1635 ,  A61K9/1694 ,  A61K9/5026

摘要： The invention relates to a method for the production of active ingredient-containing pellets by the steps of a) suspending or dissolving a pharmaceutical active ingredient in a dispersion, which contains a cationic copolymer, b) dropping said dispersion, containing the pharmaceutical active ingredient and the copolymer in an aqueous polymer solution, which contains an anionic copolymer, incompatible with the cationic copolymer, so that active ingredient-containing pellets precipitate and c) separating said active ingredient-containing pellets from the aqueous polymer solution and then drying said pellets. The invention also relates to said pellets and the use thereof in diagnostics or cosmetics, as well as pharmaceutical forms which contain said pellets.

摘要翻译： 本发明涉及通过以下步骤生产含活性成分的粒料的方法：a）将药物活性成分悬浮或溶解在含有阳离子共聚物的分散体中，b）滴加含有药物活性成分的分散体和 含有阴离子共聚物的聚合物水溶液中的共聚物，其与阳离子共聚物不相容，使得含活性成分的颗粒沉淀并且c）从聚合物水溶液中分离所述含活性成分的颗粒，然后干燥所述颗粒。 本发明还涉及所述丸粒及其在诊断或化妆品中的用途，以及含有所述丸粒的药物形式。

公开(公告)号：US20040234610A1

公开(公告)日：2004-11-25

申请号：US10309644

申请日：2002-12-04

发明人： Jesse B. Hall ,  John P. Kress ,  Sherwin E. Morgan ,  Jeffrey H. Ping ,  W. Randolph Warner

IPC分类号： A61K009/14 ,  B29B009/00

CPC分类号： A61M11/06 ,  A61M15/0088 ,  A61M16/06 ,  A61M16/08 ,  A61M16/0833 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/025

摘要： Medical devices and methods are provided for the pulmonary delivery of a drug in heliox gas. One method comprises (a) providing a medical device which comprises an aerosolization means, a conduit means, a gas mask, and a source of heliox gas, the medical device being operable as a closed system to prevent entrainment of ambient air into an inhaled aerosol; (b) providing a drug in a liquid or dry powder form; (c) using the aerosolization means to form an aerosol of particles or droplets dispersed in heliox gas, said particles or droplets comprising the drug and said heliox gas being from said source; and (d) flowing the aerosol through the conduit means and into the gas mask secured over a patient's mouth and nose in a manner for the patient to inhale the aerosol without dilution of the aerosol with ambient air.

摘要翻译： 提供了用于氦气中药物肺部递送的医疗装置和方法。 一种方法包括（a）提供包括雾化装置，导管装置，防毒面具和氦气源的医疗装置，该医疗装置可操作为封闭系统，以防止将环境空气夹带入吸入气溶胶 ; （b）提供液体或干粉形式的药物; （c）使用雾化装置形成分散在氦气中的颗粒或液滴的气溶胶，所述包含药物的所述颗粒或液滴和来自所述源的所述氦气; 和（d）将气溶胶流过导管装置并进入固定在患者口和鼻上的防毒面具，以使患者吸入气溶胶而不用气溶胶与环境空气稀释。

公开(公告)号：US20040119179A1

公开(公告)日：2004-06-24

申请号：US10399595

申请日：2004-02-17

发明人： Michel Perrut ,  Jennifer Jung ,  Fabrice Leboeuf ,  Isabelle Fabing

IPC分类号： B29B009/00

CPC分类号： B82Y5/00 ,  A61K47/6951

摘要： The invention concerns a method for making very fine particles containing at least an active principle inserted in a host molecule and a device for implementing said method. The method is characterized in that it consists in forming a solution of the active principle in a first liquid solvent and of a product formed by the host molecules in a second liquid solvent, then in contacting the resulting solutions with a supercritical pressure fluid, so as to precipitate the host molecules which are dissolved therein.

摘要翻译： 本发明涉及一种制备非常细的颗粒的方法，所述方法至少包含插入主体分子中的活性成分和用于实现所述方法的装置。 该方法的特征在于它包括在第一液体溶剂中形成活性成分的溶液和在第二液体溶剂中由主体分子形成的产物，然后使所得溶液与超临界压力流体接触，以便 以沉淀溶解在其中的主体分子。

公开(公告)号：US20040113300A1

公开(公告)日：2004-06-17

申请号：US10356330

申请日：2003-01-31

申请人： Buhler AG

发明人： Theodor Jurgens ,  Rudolf Geier

IPC分类号： B29B009/00

CPC分类号： B01J2/04 ,  B29B9/10 ,  B29B9/16 ,  B29B2009/165 ,  B29B2009/166 ,  B29C2791/008 ,  B29K2067/00 ,  B29K2067/006

摘要： The invention relates to a method and a device for the production of spherical particles, whereby a molten prepolymer or precondensate is transformed into droplets by means of a drip nozzle, the droplets are subjected to a countercurrent with a gas in a precipitation column until at least partial crystallization is achieved and are then subjected to an additional post-crystallization phase. In order to economically produce higher quality particles at a high flow rate, the molten prepolymer is transformed into droplets by means of a vibrating nozzle plate and/or direct vibration of the molten prepolymer or polymer and resulting droplets are subjected to an air and gas countercurrent.

摘要翻译： 本发明涉及一种用于生产球形颗粒的方法和装置，其中熔融预聚物或预缩合物通过滴水喷嘴转化成液滴，使液滴与沉淀柱中的气体逆流直到至少 实现部分结晶，然后进行另外的后结晶相。 为了以高流速经济地生产更高质量的颗粒，熔融预聚物通过振动喷嘴板转化成液滴，和/或熔融预聚物或聚合物的直接振动，并使所得到的液滴经受空气和气体逆流 。

公开(公告)号：US20040091542A1

公开(公告)日：2004-05-13

申请号：US10466365

申请日：2003-12-11

发明人： Wiwik Watanabe ,  Esko Kauppinen ,  Petri Ahonen ,  David Brown ,  Esa Muttonen

IPC分类号： A61K009/14 ,  B29B009/00

CPC分类号： A61K9/5192 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01J13/0004

摘要： The invention relates to free nano-sized particles of active agents e.g. therapeutic, cosmetic or diagnostic agents, and to a method for the preparation of such particles. The method comprises providing a liquid feed stock comprising an active agent or combination of two or more active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Nano-sized crystalline spherical uncharged particles with narrow aerodynamic particle size distribution and rough surfaces, are obtained. The particles show improved dissolution rate in-vitro and bioavailability in-vivo, dispersibility and stability.

摘要翻译： 本发明涉及活性剂的游离纳米尺寸颗粒，例如 治疗剂，化妆品或诊断剂，以及制备这种颗粒的方法。 该方法包括提供液体原料，其包含活性剂或两种或更多种活性剂的组合，使液体原料雾化，将液滴悬浮在载气中，并使载气和液滴通过加热的管流反应器在预定的 停留时间和温度历史，并收集生成的颗粒。 获得具有窄空气动力学粒度分布和粗糙表面的纳米尺寸的结晶球形不带电粒子。 颗粒体外显示改善的溶出速率和体内，分散性和稳定性的生物利用度。

公开(公告)号：US20040007790A1

公开(公告)日：2004-01-15

申请号：US10418317

申请日：2003-04-18

发明人： Kenji Kato ,  Yukio Yamaguchi ,  Seiichi Isomae ,  Masaki Miyazaki

IPC分类号： B29B009/00 ,  B05C005/00 ,  C23C016/00 ,  C23C022/70 ,  H01L021/44 ,  H01L021/20

CPC分类号： B22F9/08 ,  B01J2/04 ,  B22F2009/0816 ,  B22F2009/0888 ,  B22F2009/0892

摘要： A method for producing semiconductor or metal particles comprises the steps of: storing a semiconductor or metal melt in a crucible having a nozzle; supplying a gas comprising at least one selected from the group consisting of He, Ne, Ar, Kr and Xe into the crucible such that the pressure of the supplied gas in a space over the melt in the crucible is higher than the pressure of a gaseous phase into which the melt is dropped; dropping the melt from the nozzle into the gaseous phase by the pressure of the gas to form liquid particles; and solidifying the liquid particles in the gaseous phase to obtain semiconductor or metal particles. The crucible comprises at least one selected from the group consisting of hexagonal BN, cubic BN, Si3N4, TiB2, ZrB2, zirconia and stabilized zirconia at least near the nozzle. Alternatively, the crucible comprises quartz glass at least near the nozzle and has a heat-resistant support member for suppressing deformation caused by a decrease in viscosity of the quartz glass at high temperatures.

摘要翻译： 一种制造半导体或金属颗粒的方法包括以下步骤：将半导体或金属熔体储存在具有喷嘴的坩埚中; 将包含选自He，Ne，Ar，Kr和Xe中的至少一种的气体供应到坩埚中，使得在坩埚中的熔体上方的供应气体的压力高于气体的压力 熔体滴入其中的相; 通过气体的压力将熔体从喷嘴滴入气相中以形成液体颗粒; 并使气相中的液体颗粒固化，得到半导体或金属颗粒。 所述坩埚至少包括至少一个选自六边形BN，立方BN，Si3N4，TiB2，ZrB2，氧化锆和稳定的氧化锆的至少一种，至少在喷嘴附近。 或者，坩埚包括至少在喷嘴附近的石英玻璃，并且具有用于抑制在高温下石英玻璃的粘度降低引起的变形的耐热支撑构件。

公开(公告)号：US20030232995A1

公开(公告)日：2003-12-18

申请号：US10425504

申请日：2003-04-29

发明人： Joe W. Curtis ,  Marudai Balasubramanian ,  Joel R. Calvin ,  Eric F.V. Scriven ,  Charles R. Hopper ,  Ramiah Murugan ,  L. Mark Huckstep

IPC分类号： C07D213/72 ,  B29B009/00

CPC分类号： C07D213/73 ,  B01J31/0237 ,  B01J31/0244 ,  B01J35/023 ,  B01J37/0063 ,  B01J2231/4205 ,  C07D213/74 ,  C07D213/84

摘要： Described are preferred processes for producing extrusion-granulated supernucleophilic 4-amino-substituted pyridine catalysts, and granular products obtainable thereform. Also described are preferred activation-substitution-deactivation processes for producing 4-aminopyridine compounds, which involve the use of acrylic acid or acrylamide or analogs thereof for activation, and substitution steps conducted under mild basic conditions in an excess of the amine reagent for 4-substitution. Such processes provide improved reacted masses which are more readily processed to recover the products in pure, heat-stable form. Further, described are processes for preparing 4-substituted-pyridines via pyridine betaines.

公开(公告)号：US20030222363A1

公开(公告)日：2003-12-04

申请号：US10150234

申请日：2002-05-17

发明人： Vivek Kapur ,  Govindasamy Paramasivan Rajendran ,  Kenneth Wayne Leffew

IPC分类号： B29B009/00

CPC分类号： C08G63/88 ,  C08L67/02 ,  C08L2666/18

摘要： A process for forming solid particles comprising the steps of: combining in molten form a major component of a crystallizable condensation homopolymer and a minor component of a non-crystallizable condensation polymer, wherein the crystallizable condensation homopolymer and the non-crystallizable condensation polymer each have a degree of polymerization of 10 to less than 48 prior to the combining; mixing the combined crystallizable condensation homopolymer and non-crystallizable condensation polymer in molten form to form a mixture that comprises 10 to 30 mol % of the non-crystallizable condensation polymer; forming the mixture into droplets; exposing the droplets to a thermal environment which results in the bulk of the droplet reaching within 15 seconds a temperature within null10null C. of the temperature at which the maximum rate of crystallization of the crystallizable condensation homopolymer occurs; and crystallizing at least a portion of the crystallizable condensation homopolymer in the mixture to form solid particles.

摘要翻译： 一种形成固体颗粒的方法，包括以下步骤：以熔融形式混合可结晶的缩合均聚物的主要组分和不可结晶的缩聚物的次要组分，其中可结晶的缩合均聚物和不可结晶的缩聚物各自具有 在组合之前聚合度为10至小于48; 将熔融形式的组合的可结晶的缩合均聚物和不可结晶的缩聚物混合以形成包含10至30摩尔％的不可结晶缩合聚合物的混合物; 将混合物形成液滴; 将液滴暴露于导致大部分液滴在15秒内达到可结晶冷凝均聚物最大结晶速率的±10℃以内的温度的热环境中; 并使混合物中至少一部分可结晶的缩合均聚物结晶以形成固体颗粒。

公开(公告)号：US20030183973A1

公开(公告)日：2003-10-02

申请号：US10376580

申请日：2003-02-28

申请人： Minebea Co., Ltd.

发明人： Kazuo Hokkirigawa ,  Rikuro Obara

IPC分类号： B29B009/00

CPC分类号： F16C33/201 ,  C08K3/04 ,  F16C17/14 ,  F16C33/043 ,  Y10S384/907

摘要： According to the invention, a synthetic resin composition having a desirable a low coefficient of friction when submersed in a liquid is provided. In addition, a method of making a low friction bearing for use under liquid is provided as well as a low friction bearing or use underwater. According to the invention, a synthetic resin composition with lubricative underwater properties is provided. A powder preferably a fine powder of a RBC, CRBC or both are uniformly dispersed in a synthetic resin. Desirably the weight ratio between RBC or CRBC powders and the synthetic resin is 30:90 to 70:10.

摘要翻译： 根据本发明，提供了当浸入液体中时具有低摩擦系数的合成树脂组合物。 此外，提供了一种制造在液体下使用的低摩擦轴承的方法以及低摩擦轴承或在水下使用。 根据本发明，提供了一种具有润滑水下特性的合成树脂组合物。 优选粉末中RBC，CRBC或两者的粉末均匀分散在合成树脂中。 理想地，RBC或CRBC粉末与合成树脂之间的重量比为30:90至70:10。

公开(公告)号：US20030180367A1

公开(公告)日：2003-09-25

申请号：US10260788

申请日：2002-09-30

申请人： SkyePharma Canada, Inc.

发明人： Indu Parikh ,  Ulagaraj Selvaraj

IPC分类号： A61K009/14 ,  B29B009/00

CPC分类号： B82Y5/00 ,  A61K9/145

摘要： The invention provides a composition comprising microparticles of a water-insoluble or poorly soluble compound, at least one phospholipid, and at least one surfactant, produced by applying an energy to a mixture comprising particles of the compound, the at least one phospholipid, and the at least one surfactant so as to obtain the microparticles. The invention also provides a process for preparing microparticles of a water-insoluble or poorly soluble compound. The process includes mixing particles of a water-insoluble or poorly soluble compound with at least one phospholipid and at least surfactant to form a mixture and applying energy to the mixture sufficient to produce microparticles of the compound. The methods of the invention allow for the production of microparticles smaller than particles produced through previously known methods and the microparticles exhibit advantageous properties including remarkable resistance to particle size growth during storage.

摘要翻译： 本发明提供一种组合物，其包含水不溶性或难溶性化合物的微粒，至少一种磷脂和至少一种表面活性剂，其通过将能量施加到包含化合物颗粒，至少一种磷脂和 至少一种表面活性剂以获得微粒。 本发明还提供了制备水不溶性或难溶性化合物的微粒的方法。 该方法包括将水不溶性或难溶性化合物的颗粒与至少一种磷脂和至少表面活性​​剂混合形成混合物，并向混合物施加足以产生化合物微粒的能量。 本发明的方法允许生产比通过先前已知的方法制备的颗粒小的微粒，并且微粒表现出有利的性质，包括在储存期间显着抗性粒径生长。