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    2-Amino-6-biphenylacetic acids
    1.
    发明授权
    2-Amino-6-biphenylacetic acids 失效
    2-氨基-6-联苯乙酸

    公开(公告)号：US4333951A

    公开(公告)日：1982-06-08

    申请号：US165323

    申请日：1980-07-02

    Applicant: David A. Walsh

    Inventor： David A. Walsh

    IPC: C07D209/34 ,  C07C101/447 ,  A61K31/195 ,  A61K31/215

    CPC classification number: C07D209/34 ,  Y10S514/906

    Abstract: Novel 2-amino-6-biphenylacetic acids, esters, and metal salts are provided of the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R.sup.1 represents fluoro, chloro, bromo, lower-alkyl or amino; R.sup.2 represents lower-alkyl, lower-alkoxy, fluoro, chloro, bromo, amino or trifluoromethyl; n is 0-3 and m is 0-2, and the pharmaceutically acceptable salts thereof. The compounds exhibit muscle relaxant activity, and are also useful as anti-inflammatory agents.

    Abstract translation: 新的2-氨基-6-联苯乙酸，酯和金属盐由下式提供：其中R表示氢或低级烷基，R 1表示氟，氯，溴，低级烷基或氨基; R 2表示低级烷基，低级烷氧基，氟，氯，溴，氨基或三氟甲基; n为0-3，m为0-2，及其药学上可接受的盐。 化合物显示肌肉松弛剂活性，并且也可用作抗炎剂。

    Novel substituted phenylacetic acid amide compounds
    4.
    发明授权
    Novel substituted phenylacetic acid amide compounds 失效
    新型取代苯乙酸酰胺化合物

    公开(公告)号：US4250192A

    公开(公告)日：1981-02-10

    申请号：US033295

    申请日：1979-04-25

    Applicant: Alfred Sallmann ,  Gerhard Baschang

    Inventor： Alfred Sallmann ,  Gerhard Baschang

    IPC: A61K38/00 ,  C07K5/02 ,  C07C101/447 ,  A01N37/10 ,  A01N37/12

    CPC classification number: C07K5/0202 ,  A61K38/00

    Abstract: Phenylacetic acid amide compounds of the formula ##STR1## in which R.sub.1 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, R.sub.3 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, and in which R.sub.5 is a radical of aliphatic character containing the group R.sub.6, R.sub.6 and R.sub.7 are each hydrogen or together are a divalent alipahtic radical and the group of the formula --C(.dbd.O)--R.sub.8 (Ia) is a carboxyl group, which can be functionally modified, and their salts are useful as anti-inflammatory agents.

    Abstract translation: 其中R1是氢，低级烷基，低级烷氧基，原子序数不多于35的卤素或三氟甲基，R2是氢，低级烷基，低级烷氧基，卤素，具有式（Ⅰ）的苯乙酸酰胺化合物 原子序数不大于35或三氟甲基，R3是氢原子数不多于35的氢，低级烷基，低级烷氧基或卤素，R4是氢原子数不多于的氢，低级烷基，低级烷氧基或卤素 并且其中R 5是含有基团R 6的脂族基性基团，R 6和R 7各自为氢或一起为二价基团，式-C（= O）-R8（Ia）的基团为 羧基，其可以被功能修饰，并且它们的盐可用作抗炎剂。

    Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds
    6.
    发明授权
    Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds 失效
    取代的氮杂双环庚烷，其用途，含有这些化合物的药物制剂，以及这些化合物的制造方法

    公开(公告)号：US4764640A

    公开(公告)日：1988-08-16

    申请号：US32656

    申请日：1987-04-01

    Applicant: Alex Alder ,  Jaroslaw Stanek ,  Daniel Bellus

    Inventor： Alex Alder ,  Jaroslaw Stanek ,  Daniel Bellus

    IPC: A61K31/435 ,  A61P35/00 ,  A61P43/00 ,  C07D211/88 ,  C07D221/22 ,  C07D311/00 ,  C12N9/99 ,  C07C101/447

    CPC classification number: C07D221/22 ,  C07D311/00

    Abstract: 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

    Abstract translation: 式（Ⅰ）的1-苯基-3-氮杂双环[3.1.1] - 庚烷-2,4-二酮其中R 1表示氢或饱和或不饱和的脂族，脂环族，脂环族 - 脂族，脂族，芳族或 具有至多并包括18个，优选至多且包含12个碳原子的芳族 - 脂族烃基，R 2表示氢，低级烷基，磺基或酰基，R 3表示氢或低级烷基，R 4表示氢，低级烷基，苯基或苯基 被-N（R2）（R3）取代，并且这些化合物的盐具有有价值的药理学性质，作为芳香酶抑制剂是有效的，因此可用于治疗激素依赖性疾病，特别是乳腺癌。

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