摘要:
The invention provides a novel process for making novel (4-phenyl-1,3,-dioxan-cis-5-yl)alkenoic acids of the formula I in which Ra and Rb are independently hydrogen, alkenyl, alkyl, halogenoalkyl, pentafluorophenyl, aryl or aryl-(1-4C)alkyl; or Ra and Rb together are polymethylene; Rc is hydroxy or (1-6C)alkanesulphonamido, A is vinylene, n is 1, Y is polymethylene, and benzene ring B bears various optional substituents. The process involves the reaction of an aldehyde of formula II with an ylid to give an erythro-diol of formula III which is then cyclized to the required dioxane derivative of formula I. The invention also provides a novel process for making the aldehydes of formula II from the corresponding lactols of formula IIa, which are themselves obtained with the correct trans-stereochemistry by two selective reductions of a trans-phenylparaconic acid of formula V. The compounds of formula I are useful as therapeutic agents.
摘要:
N-(haloalkyl)sulfonamides represented by the formula ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.20 aryl, alkaryl, aralkyl or alkyl group; R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or methyl groups; n is the integer 0 or 1 and X is a chloro, bromo or iodo group, are prepared by reacting an N-(haloalkyl)sulfonyl imide with a C.sub.1 -C.sub.6 alkanol.
摘要:
Mite eggs are killed by applying thereto N-tetrachloroethylthio-substituted halomethanesulfonamides of the formula ##STR1## wherein R is alkyl, cycloalkyl, aryl, X is fluoro, chloro, bromo or iodo and R' is tetrachloroethyl.
摘要:
The sulfonamidophenethanolamine 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide is an antihypertensive beta-adrenergic blocking agent selectively lowering blood pressure with minimal reduction of heart rate.
摘要:
Segmented fluorocarbon sulfonic acids comprising the reaction product of a perfluoroalkyl-alkyl halide and a sulfonation reagent as well as the acid anhydrides, metal salts, sulfonyl halides and sulfonamides thereof. The resulting compositions possess unique surface active properties and thus are applicable as effective emulsifying agents. They may also be used as intermediates in the preparation of water and oil repellency agents.
摘要:
Alpha -Aminoalkyl-4-hydroxy-3-sulfamoylaminobenzyl alcohols having Beta -adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from 3-amino-4benzyloxyphenones by, for example, reaction with a sulfamoyl chloride to give 3-sulfamoylaminophenones, bromination of these phenones and treatment of the resulting Alpha -bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.
摘要:
The invention relates to a sulphonic acid amidamine corresponding to the following general formula I: ##STR1## wherein R.sup.1 represents a C.sub.8 -C.sub.30 linear, saturated aliphatic hydrocarbon group or said group which is substituted by one or more chlorine atoms;R.sup.2 and R.sup.5 independently represent hydrogen or C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl which is substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl, and/or is interrupted by at least one oxy (--O--) or thio (--S--) group;R.sup.3 and R.sup.4 independently represent C.sub.2 -C.sub.13 alkylene or C.sub.5 -C.sub.7 cycloalkylene or said alkylene or cycloalkylene groups which are substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl;p represents zero or an integer of from 1 to 3;q represents zero or an integer of from 1 to 12; andn represents an integer of from 1 to 8.
摘要:
This invention provides Class III anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is alkylsulfonamido, arylsulfonamido, perfluoroalkylsulfonamido, R.sup.2 and R.sup.3 are hydrogen or alkyl, R.sup.4 is alkyl, and n is 2 to 4, or a pharmaceutically acceptable salt thereof.