摘要:
A novel process is provided for the preparation of optical isomers of certain sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking agents which can be used for various treatments such as for the treatment of congestive heart failure.
摘要:
3-Alkylamino-5-sulfamyl benzoic acid derivatives are prepared by reducing 3-acylamino-5-sulfamyl-benzoic acid derivatives by means of boron hydrides or complex boron hydrides in the presence of Lewis acids.
摘要:
A group of novel N4-substituted-N1-alkoxy(alkylthio)-3,5dinitrosulfanilamides are herbicides which are particularly useful for preemergence control of weeds in ornamental turf.
摘要:
THIS INVENTION RELATES TO NEW 4-SUBSTITUTED 5-SULFAMYLANTHRANILIC ACIDS, AND SALTS AND ESTERS THEREOF, HAVING A PRONOUNCED DIURETIC AND SALURETIC EFFECT; TO METHODS OF PRODUCING THE SAID COMPOUNDS; AND TO PHARMACEUTICAL COMPOSITIONS IN DOSAGE UNIT FORM CONTAINING THE SAID COMPOUNDS AS ACTIVE INGREDIENTS.
摘要:
hydrogen, fluorine, chlorine, bromine, an alkyl residue or an alkoxy residue having one to four carbon atoms, with the sum of the carbon atoms of the residues R1 and R2 not exceeding the number seven, Ar denotes a benzene or naphthalene residue, R3 denotes hydrogen, an alkyl residue having not more than four carbon atoms, the Beta -cyanoethyl residue or a hydroxyalkyl residue having two to four carbon atoms, R4 denotes an alkylene radical having three to 15 carbon atoms in the chain which may furthermore optionally be substituted by methyl or ethyl groups, and m and n are each 1 or 2.
摘要:
Novel 5-phenyl-tetrazole derivatives of the general formula:
WHEREIN X is a halogen atom, an azido group or a trifluoromethyl radical, R1 is a hydrogen atom or a lower alkyl radical, R2 is a phenyl, furyl or thienyl radical and n is 0, 1 or 2; and the pharmacologically compatible salts thereof, possess exceptional diuretic and saluretic properties.
摘要:
COMPOUNDS USEFUL IN PREPARING QUINAZOLINONE COMPOUNDS HAVING SUPERIOR DIURETIC PROPERTIES HAVE THE FOLLOWING GENERIC FORMULA:
1-((R3,R4,R5-PHENYL)-NH-CO-),2-(R7-N(-R6)-),4-X,
5-(R"-NO2(-R'')-S-)BENZENE
OR THE PHARMACEUTICALLY ACCCEPTABLE SALTS THEREOF, WHEREIN X IS HALOGEN OR TRIFLUOROMETHYL; R'' AND R" ARE HYDROGEN, LOWER ALKYL, PHENYLLOWERALKYL OR PHENYL; R6 AND R7 ARE HYDROGEN, LOWER ALKYL, PHENYL, PHENYL LOWER ALKYL, AMINO LOWER ALKYL, LOWER ALKYL AMINO LOWER ALKYL, LOWER ALKANOYL OR HYDROXY LOWER ALKYL, AND R3, R4 AND R5 ARE HYDROGEN, LOWER ALKYL, HYDROXY, LOWER ALKOXY, AMINO, LOWER ALKOXY LOWER ALKYL, HALOGEN, SULFAMYL OR TRIFLUOROMETHYL. THE ABOVE COMPOUNDS ARE MADE, FOR EXAMPLE, BY REACTING 4-CHLORO-5-SULFAMYL ANTHRANILIC ACID WITH LIQUID PHOSGENE IN GLACIAL ACETIC ACID AND THE PRODUCT DRIED OVER P2O5 TO PRODUCE 7-CHLORO-6-SULFAMYLISATOIC ANHYDRIDE. THIS COMPOUND WAS THEN REACTED WITH O-TOLUIDINE, P-CHLOROANILINE, OR OTHER SUBSTITUTED ANILINE TO GIVE THE AMIDE OF THIS INVENTION.
摘要:
2-AMINO-4-PHENYLSULFONYL-BENZENESULFONAMIDE HAS A REMARKABLE ANTICONVULSIVE EFFECT, PAIRED WITH ABSENCE OF SEDATIVE EFFECT. ITS TOXICITY IS LOW. IT IS PRODUCED BY FRIEDEL-CRAFTS REACTION BETWEEN 4CHLORO-3-NITROBENZENESULFONIC-ACID CHLORIDE AND BENZENE. SULFIDIZING TO FORM THE DISULFIDE COMPOUND, OXIDATION, AMINATION AND REDUCTION OF THE NITRO GROUPS.