摘要:
Provided herein are inter alia, unnatural amino acids based on fluorosulfonyloxybenzoyl-L-lysine FSK, proteins comprising unnatural amino acids, nanobodies comprising unnatural amino acids based on fluorosulfate-L-tyrosine FSY, meta-FSY and FFY within CDR1, CDR2, or CDR3, biomolecule conjugates, and methods of making the proteins and biomolecule conjugates.
摘要:
The instant invention is directed to a substituted polyisocyanate or polyisocyanate mixtures of the diphenyl methane series containing chlorosulfonyl groups, a process for the preparation thereof and the use thereof for the preparation of polyisocyanate polyaddition compounds.
摘要:
The present invention provides (I) a method of manufacturing a triphenylmethane colorant that can suppress the sub-reactions in conversion to a sulfonamide and is industrially advantageous, (II) a colorant compound that has both excellent spectral characteristics and a high solubility relative to organic solvents or polymers as a coloring agent to be used in color filters and (III) a blue resist composition for use in a color filter that shows a high lightness and an excellent hue particularly for blue color and can be used to display an image that is excellent in terms of spectral characteristics and contrast.
摘要:
The present invention provides a compound of formula (1) ##STR1## in which: R.sub.4 represents a hydrogen atom, a halogen atom or a nitro group; R.sub.6 represents a hydrogen atom or a straight or branched (C.sub.1 -C.sub.6)alkyl group; R.sub.7 represents a chlorine atom or a hydroxyl group; and Z represents: a phenyl group optionally substituted with one or more halogen atoms, straight or branched (C.sub.1 -C.sub.4)alkyl groups, straight or branched (C.sub.1 -C.sub.4)alkoxy groups, or trifluoromethyl, formyl, --CH.sub.2 OR, --CH.sub.2 OCOR, --CH.sub.2 CONRR', --CH.sub.2 ONCOR, --COOR, nitro, --NHR, --NRR' or --NHCOR groups, wherein R and R' are each, independently, a hydrogen atom or a (C.sub.1 -C.sub.7)alkyl group; a heterocyclic group optionally substituted as defined above for phenyl; or a cyclo(C.sub.5 -C.sub.8)alkyl group; additionally, when R.sub.7 represents chlorine, Z can represent iodine; in the free form or in the form of a salt with an alkali metal or tertiary amine, processes for their preparation and their use as synthetic intermediates.
摘要:
A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.
摘要:
The present Application discloses pesticidally active compounds of formula (I):Q(CH.sub.2).sub.a (O).sub.b Q.sup.1 CR.sup.2 .dbd.CR.sup.2 .dbd.CR.sup.3 CR.sup.4 .dbd.CR.sup.5 CXNR.sup.1 R.sup.xor a salt or propesticide thereof, wherein Q is an optionally substituted aromatic monocyclic or fused bicyclic ring system in which at least one ring is aromatic, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halo or hydrogen; Q.sup.1 is a 1,2-cyclopropyl ring optionally substituted by one or more groups selected from C.sub.1-3 alkyl, halo, C.sub.1-3 haloalkyl, C.sub.2-3 alkynyl, or cyano; or is (CH.sub.2).sub.7 ;a=0 or 1; b= 0 or 1;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl;X is oxygen or sulphur;R.sup.1 is phenyl optionally substituted by 1-5 substituents chosen from:a) C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenoxy and methylenedioxy, each optionally substituted by 1 to 5 halo;b) halo, cyano, nitro, formyl, C.sub.1-5 acyl;c) C.sub.2-3 alkynyl, C.sub.2-3 alkenyl, each optionally substituted by 1 to 5 halo;d) a group S(O).sub.n R.sup.7 wherein n=0,1,2 and R.sup.7 is C.sub.1-4 alkyl, halo or NR.sup.8 R.sup.9 wherein R.sup.8 and R.sup.9 are independently selected from hydrogen, C.sub.1-4 alkyl and C.sub.1-4 acyl;and a group e) NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are as defined above;R.sup.X is hydrogen or an optionally substituted C.sub.1-8 alkyl or benzyl group, their preparation, pesticidal compositions containing them and their use against pests.
摘要翻译:本申请公开了式(I)的杀虫活性化合物:Q(CH2)a(O)bQ1CR2 = CR2 = CR3CR4 = CR5 CXNR1Rx或其盐或杀虫剂,其中Q是任选取代的芳族单环或稠合双环体系 其中至少一个环是芳族的,或Q是二卤代乙烯基或R6-C 3BONDC,其中R6是C1-4烷基,三C1-4烷基甲硅烷基,卤素或氢; Q1是任选被一个或多个选自C 1-3烷基,卤素,C 1-3卤代烷基,C 2-3炔基或氰基的基团取代的1,2-环丙基环; 或为(CH 2)7; a = 0或1; b = 0或1; R 2,R 3,R 4和R 5相同或不同,至少一个为氢,其余独立地选自氢,卤素,C 1-4烷基或C 1-4卤代烷基; X是氧或硫; R1是任选被1-5个选自下列的取代基取代的苯基:a)C 1-4烷基,C 1-4烷氧基,苯氧基和亚甲二氧基,各自任选被1至5个卤素取代; b)卤素,氰基,硝基,甲酰基,C 1-5酰基; c)C2-3炔基,C2-3烯基,各自任选被1至5个卤素取代; d)基团S(O)n R 7,其中n = 0,1,2,R 7为C 1-4烷基,卤素或NR 8 R 9,其中R 8和R 9独立地选自氢,C 1-4烷基和C 1-4酰基; 和基团e)NR 8 R 9,其中R 8和R 9如上所定义; RX是氢或任选取代的C 1-8烷基或苄基,它们的制备方法,含有它们的杀虫组合物及其对害虫的用途。
摘要:
Cyan couplers of the formula: ##STR1## wherein R=a ballast groupX=H or a leaving group which may be separated during color couplingY=halogen, alkyl, alkoxy, aryl or alkylthion=0 to 2 (if n=2, the radicals Y may be the same or different)have good dark fading stability of the coupled dye, moreover low secondary color densities and a sufficiently long-wave absorption maximum which is density-independent, furthermore they have high coupling activity and good solubility in high-boiling solvents.
摘要:
NOVEL SUBSTITUTED N-(PHENYL-CARBAMYL)-AMINOBENZENE-SULFONYL FLUORIDES HAVING USEFUL BIOLOGICAL ACTIVITY WHICH HAS BEEN DEMONSTRATED IN INHIBITING BACTERIAL GROWATH AS WELL AS FUNGAL GROWTH. THESE N-(PHENYL-CARBAMYL)-AMINO-BENZENE-SULFONYL FLUORIDES HAVE THE GENEREL FORMULA:
(XM,X''N-PHENYL)-NH-CO-NH-C6H4-SO2-F
WHEREIN X IS CHLORIDE, BROMINE TRIFLUOROMETHYL, NETHOXY OR FLUOROSULFONYL; X'' IS HYDROGEN, CHLORIDE, BROMINES, TRIFLUOROMETHYL, METHOXY OR FLUOROXULFONYL; M IS A WHOLE NUMBER FROM 1 TO 3, AND N IS A WHOLE NUMBER FROM 1 TO 3.