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11 条记录 (耗时 0.023 秒)

    LITHIUM METAL DOPED ELECTRODES FOR LITHIUM-ION RECHARGEABLE CHEMISTRY
    2.
    发明申请
    LITHIUM METAL DOPED ELECTRODES FOR LITHIUM-ION RECHARGEABLE CHEMISTRY 有权
    用于锂离子可充电化学的锂金属掺杂电极

    公开(公告)号：US20140227432A1

    公开(公告)日：2014-08-14

    申请号：US14347957

    申请日：2012-10-05

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Gao Liu ,  Vince Battaglia ,  Lei Wang

    IPC分类号： H01M4/04 ,  H01M4/36

    CPC分类号： H01M4/0404 ,  H01M4/0416 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/366 ,  H01M4/587 ,  H01M4/622 ,  H01M4/623 ,  H01M4/625 ,  H01M10/0525 ,  Y02E60/122

    摘要： An embodiment of the invention combines the superior performance of a polyvinylidene difluoride (PVDF) or polyethyleneoxide (POE) binder, the strong binding force of a styrene-butadiene (SBR) binder, and a source of lithium ions in the form of solid lithium metal powder (SLMP) to form an electrode system that has improved performance as compared to PVDF/SBR binder based electrodes. This invention will provide a new way to achieve improved results at a much reduced cost.

    摘要翻译： 本发明的一个实施方案结合了聚偏二氟乙烯（PVDF）或聚环氧乙烷（POE）粘合剂的优异性能，苯乙烯 - 丁二烯（SBR）粘合剂的强结合力和固体锂金属形式的锂离子源 粉末（SLMP），以形成与基于PVDF / SBR粘合剂的电极相比具有改进的性能的电极系统。 本发明将提供一种以大大降低成本实现改进结果的新方式。

    Mutant Aminoacyl tRNA Synthetase
    5.
    发明申请
    Mutant Aminoacyl tRNA Synthetase 有权

    公开(公告)号：US20220411778A1

    公开(公告)日：2022-12-29

    申请号：US17818919

    申请日：2022-08-10

    申请人： The Regents of the University of California

    发明人： Lei Wang

    IPC分类号： C12N9/88 ,  C07F9/12 ,  C07F9/24 ,  C12N9/00 ,  C12N15/52 ,  C12N15/63

    摘要： Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosine precursors are subsequently treated to convert them into phosphotyrosine residues, yielding proteins with phosphotyrosines at selected sites. The scope of the invention encompasses novel aminoacyl tRNA synthetases, novel phosphotyrosine precursors, and methods of using these materials to create site-specific phosphorylated tyrosine residues in a protein.

    Site-specific generation of phosphorylated tyrosines in proteins
    9.
    发明授权
    Site-specific generation of phosphorylated tyrosines in proteins 有权

    公开(公告)号：US11447764B2

    公开(公告)日：2022-09-20

    申请号：US16484757

    申请日：2018-02-13

    申请人： The Regents of the University of California

    发明人： Lei Wang

    IPC分类号： C12N9/88 ,  C07F9/12 ,  C07F9/24 ,  C12N9/00 ,  C12N15/52 ,  C12N15/63

    摘要： Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosine precursors are subsequently treated to convert them into phosphotyrosine residues, yielding proteins with phosphotyrosines at selected sites. The scope of the invention encompasses novel aminoacyl tRNA synthetases, novel phosphotyrosine precursors, and methods of using these materials to create site-specific phosphorylated tyrosine residues in a protein.

    MULTI-TARGET CROSSLINKERS AND USES THEREOF
    10.
    发明申请
    MULTI-TARGET CROSSLINKERS AND USES THEREOF 有权

    公开(公告)号：US20220107327A1

    公开(公告)日：2022-04-07

    申请号：US17281179

    申请日：2019-10-02

    申请人： The Regents of the University of California

    发明人： Lei Wang ,  Bing Yang ,  Haifan Wu ,  William DeGrado ,  Jun Liu

    IPC分类号： G01N33/68

    摘要： Disclosed herein, inter alia, are compositions and methods for cross-linking biomolecules. In an aspect is provided a method of detecting a covalently conjugated molecule, the method including i) contacting a first biomolecule and a second biomolecule with a crosslinking agent to form a covalently conjugated biomolecule; ii) identifying a first point of attachment of the crosslinking agent to the first biomolecule using mass spectroscopy; and iii) identifying a second point of attachment of the crosslinking agent to the second biomolecule using mass spectroscopy; thereby detecting a covalently conjugated molecule.