公开(公告)号：US5693630A

公开(公告)日：1997-12-02

申请号：US325279

申请日：1994-10-26

Applicant: Stefan Bengtsson ,  Sven Hellberg ,  Nina Mohell ,  Lian Zhang ,  Gerd Hallnemo ,  David Jackson ,  Bengt Ulff

Inventor： Stefan Bengtsson ,  Sven Hellberg ,  Nina Mohell ,  Lian Zhang ,  Gerd Hallnemo ,  David Jackson ,  Bengt Ulff

IPC: C07C233/62 ,  A61K31/165 ,  A61K31/215 ,  A61K31/255 ,  A61K31/275 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/55 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07C237/04 ,  C07C237/06 ,  C07C237/16 ,  C07C255/58 ,  C07C327/14 ,  C07D207/40 ,  C07D207/404 ,  C07D207/408 ,  C07D209/40 ,  C07D209/48 ,  C07D211/88 ,  C07D221/20 ,  C07D223/10 ,  C07C232/62 ,  C07C237/14

CPC classification number: C07D207/408 ,  C07C233/62 ,  C07C237/06 ,  C07C255/58 ,  C07D209/48 ,  C07D221/20 ,  C07D223/10 ,  C07C2101/02 ,  C07C2101/14 ,  C07C2102/44 ,  C07C2103/74

Abstract: Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R.sub.1 is a hydrogen atom, or a straight or branched C.sub.1-4 alkyl group, R.sub.2, R.sub.3 and R.sub.13 are situated in the ortho, meta, or para position of the phenyl ring and are the same or different and selected from the following groups: H, OH, OR.sub.14, halogen, CO.sub.2 R.sub.9, CN, CF.sub.3, NO.sub.2, NH.sub.2, COCH.sub.3,OSO.sub.2 CF.sub.3,OSO.sub.2 CH.sub.3,CONR.sub.10 R.sub.11, OCOR.sub.12, wherein R.sub.9, R.sub.12 and R.sub.14 is a straight or branched C.sub.1-4 alkyl group, R.sub.10 and R.sub.11 are the same or different and represents hydrogen or a straight or branched C.sub.1-6 alkyl group, R is 1) ##STR2## processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment psychiatric disorders.

Abstract translation: PCT No.PCT / SE94 / 00860 Sec。 371日期：1994年10月26日 102（e）日期1994年10月26日PCT 1994年9月16日PCT公布。 公开号WO95 / 09835 日期：1995年04月13日通式或其药学上可接受的盐的化合物，其中Z为饱和或不饱和的3至6个碳链，m为2或3，R 1为氢原子或直链或支链C1 -4-烷基，R2，R3和R13位于苯环的邻位，间位或对位，并且相同或不同，并选自下列基团：H，OH，OR14，卤素，CO 2 R 9，CN， CF 3，NO 2，NH 2，COCH 3，OSO 2 CF 3，OSO 2 CH 3，CONR 10 R 11，OCOR 12，其中R 9，R 12和R 14是直链或支链C 1-4烷基，R 10和R 11相同或不同，表示氢或直链或支链C1 -6烷基，R为1）或或或，其中变量在说明书中定义，其制备方法，含有它们的药物制剂以及该化合物在 治疗精神障碍。

公开(公告)号：US3299122A

公开(公告)日：1967-01-17

申请号：US22537362

申请日：1962-09-21

Applicant: STANDARD OIL CO

Inventor： WOLFF WILLIAM F

IPC: C07C327/14

CPC classification number: C07C327/14 ,  C07C2603/24

公开(公告)号：US4372776A

公开(公告)日：1983-02-08

申请号：US312039

申请日：1981-10-16

Applicant: Janet A. Day ,  Robert J. G. Searle

Inventor： Janet A. Day ,  Robert J. G. Searle

IPC: A01N53/00 ,  A01N53/10 ,  A01N53/12 ,  A01N55/10 ,  C07C67/00 ,  C07C227/00 ,  C07C227/06 ,  C07C229/48 ,  C07C231/00 ,  C07C231/12 ,  C07C237/24 ,  C07C241/00 ,  C07C243/06 ,  C07C243/36 ,  C07C253/00 ,  C07C255/29 ,  C07C325/00 ,  C07C327/14 ,  C07C327/24 ,  C07D203/14 ,  C07D307/52 ,  C07D333/20 ,  C07D333/24 ,  C07F7/10 ,  A01N43/10 ,  C07C69/74 ,  C07C121/78

CPC classification number: C07D333/20 ,  A01N53/00 ,  C07D333/24

Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.3 each is hydrogen or R.sup.1 and R.sup.3 together form a second carbon-to-nitrogen bond, R.sup.2 is hydrogen or cyano, R.sup.4 is alkyl and Ar is one of certain aromatic moieties.The compounds can be used as abscission agents for the loosening of fruit and/or leaves on plants.

Abstract translation: 式（I）的化合物其中R 1和R 3各自为氢或R 1和R 3一起形成第二碳 - 氮键，R 2为氢或氰基，R 4为烷基，Ar为某些芳族部分之一。 该化合物可用作植物上水果和/或叶子松动的脱落剂。

公开(公告)号：US20020019554A1

公开(公告)日：2002-02-14

申请号：US09877455

申请日：2001-06-08

Inventor： Brian C. Benicewicz ,  Subbareddiar Kanagasabapathy ,  Arumugam Sudalai

IPC: C07C327/14 ,  C07C327/02

CPC classification number: C07C327/36

Abstract: A process the preparation of a dithiocarboxylic esters comprises reacting a carboxylic acid compound of formula R1(COOH)m, a compound of formula R2AH and phosphorus pentasulfide to produce a compound of structure I. An alternate process comprises reacting a 1 compound of formula R3(COAH)m and a compound of structure II 2 in the presence of a clay catalyst; and treating products of the reaction with a thiating agent to produce a compound of structure III, a compound of structure IV, or a combination of compounds of structure III and structure IV. 3

Abstract translation: 制备二硫代羧酸酯的方法包括使式R 1（COOH）m的羧酸化合物，式R2AH的化合物和五硫化二磷反应以制备结构I的化合物。另一种方法包括使式R3化合物（COAH ）m和结构II的化合物在粘土催化剂存在下反应; 并用硫化剂处理反应产物以产生结构III的化合物，结构IV的化合物或结构III和结构IV的化合物的组合。

公开(公告)号：US4082795A

公开(公告)日：1978-04-04

申请号：US737363

申请日：1976-11-01

Applicant: Neal O. Brace

Inventor： Neal O. Brace

IPC: C07D209/70 ,  C07C67/00 ,  C07C313/00 ,  C07C323/61 ,  C07C325/00 ,  C07C327/08 ,  C07C327/14 ,  C07C327/20 ,  C07C327/24 ,  C07C327/32 ,  C07D209/94 ,  C07D307/89 ,  C07D307/93 ,  C07C61/32 ,  C07C61/12

CPC classification number: C07D307/93 ,  C07C323/00 ,  C07C327/00 ,  C07C2102/42 ,  Y10S516/01

Abstract: The compounds disclosed are of the formula ##STR1## and the anhydrides thereof wherein R.sub.f is a perfluoroalkyl group,R' is a divalent group of alkylene, ether, thioether or a sec.amine,Y is oxygen, sulfur or an amine, andR is hydrogen or alkyl.R.sup.3 is hydrogen or methylThese compounds can be prepared by a free radical catalyzed addition of a polyfluoroalkylthiol to a 5-norbornene diacid or its derivative. They are useful in preparing surfactants when reacted with an amine.

公开(公告)号：US4082798A

公开(公告)日：1978-04-04

申请号：US737866

申请日：1976-11-01

Applicant: Neal O. Brace

Inventor： Neal O. Brace

IPC: C07D209/70 ,  C07C67/00 ,  C07C313/00 ,  C07C323/61 ,  C07C325/00 ,  C07C327/08 ,  C07C327/14 ,  C07C327/20 ,  C07C327/24 ,  C07C327/32 ,  C07D209/94 ,  C07D307/89 ,  C07D307/93 ,  C07C103/19 ,  C07D209/02

CPC classification number: C07D307/93 ,  C07C323/00 ,  C07C327/00 ,  C07C2102/42 ,  Y10S516/01

Abstract: The compounds disclosed are of the formula ##STR1## and the anhydrides thereof WHEREINR.sub.f is a perfluoroalkyl group,R' is a divalent group of alkylene, ether, thioether or a sec.amine,Y is oxygen, sulfur or an amine, andR is hydrogen or alkyl.R.sup.3 is hydrogen or methylThese compounds can be prepared by a free radical catalyzed addition of a polyfluoroalkylthiol to a 5-norbornene diacid or its derivative. They are useful in preparing surfactants when reacted with an amine.

公开(公告)号：US4076740A

公开(公告)日：1978-02-28

申请号：US737463

申请日：1976-11-01

Applicant: Neal O. Brace

Inventor： Neal O. Brace

IPC: C07D209/70 ,  C07C67/00 ,  C07C313/00 ,  C07C323/61 ,  C07C325/00 ,  C07C327/08 ,  C07C327/14 ,  C07C327/20 ,  C07C327/24 ,  C07C327/32 ,  C07D209/94 ,  C07D307/89 ,  C07D307/93 ,  C07C153/11 ,  C07C153/01

CPC classification number: C07D307/93 ,  C07C323/00 ,  C07C327/00 ,  C07C2102/42 ,  Y10S516/01

Abstract: The compounds disclosed are of the formula ##STR1## and the anhydrides thereof WHEREINR.sub.f is a perfluoroalkyl group,R' is a divalent group of alkylene, ether, thioether or a sec.amine,Y is oxygen, sulfur or an amine, andR is hydrogen or alkyl.R.sup.3 is hydrogen or methylThese compounds can be prepared by a free radical catalyzed addition of a polyfluoroalkylthiol to a 5-norbornene diacid or its derivative. They are useful in preparing surfactants when reacted with an amine.

Abstract translation: 所公开的化合物具有式“IMAGE”及其酸酐，其中Rf是全氟烷基，R'是亚烷基，醚，硫醚或秒的二价基团。

公开(公告)号：US3989725A

公开(公告)日：1976-11-02

申请号：US608932

申请日：1975-08-29

Applicant: Neal O. Brace

Inventor： Neal O. Brace

IPC: C07D209/70 ,  C07C67/00 ,  C07C313/00 ,  C07C323/61 ,  C07C325/00 ,  C07C327/08 ,  C07C327/14 ,  C07C327/20 ,  C07C327/24 ,  C07C327/32 ,  C07D209/94 ,  C07D307/89 ,  C07D307/93

CPC classification number: C07D307/93 ,  C07C323/00 ,  C07C327/00 ,  C07C2102/42 ,  Y10S516/01

Abstract: The compounds disclosed are of the formula ##SPC1##And the anhydrides thereofWhereinR.sub.f is a perfluoroalkyl group,R' is a divalent group of alkylene, ether, thioether or a sec.amine,Y is oxygen, or an amine, andR is hydrogen or alkyl.R.sup.3 is hydrogen or methylThese compounds can be prepared by a free radical catalyzed addition of a polyfluoroalkylthiol to a 5-norbornene diacid or its derivative. They are useful in preparing surfactants when reacted with an amine.

Abstract translation: 所公开的化合物是下式的化合物，其中R f是全氟烷基，R'是亚烷基，醚，硫醚或仲子的二价基团。