公开(公告)号：US3847928A

公开(公告)日：1974-11-12

申请号：US30044372

申请日：1972-10-25

Applicant: BEECHAM GROUP LTD

Inventor： THOMPSON WILLIAM RAYMOND ,  RAZDAN RAJ KUMAR

IPC: A61K31/35 ,  A61K31/44 ,  C07D405/04 ,  C07F9/58 ,  C07F9/655 ,  C07D31/34

CPC classification number: C07D405/04 ,  A61K31/35 ,  A61K31/44 ,  C07F9/58 ,  C07F9/655

Abstract: 1. A MEMBER OF THE GROUP CONSISTING OF A COMPOUND HAVING THE FORMULA:

2,2,3-TRI(R1),4-(PYRIDIN-4-YL-),5-X,7-R2-CHROMANE

AND A COMPOUND HAVING THE FORMULA:

2,2,7-TRI(R1),4-(PYRIDIN-4-YL-),5-Y-CHROMENE

AND A NON-TOXIC ACID ADDITION SALT THEREOF, WHEREIN R1 IS LOWER ALKYL HAVING 1 TO 6 CARBON ATOMS, R2 IS STRAIGHT CHAIN ALKYL HAVING 1 TO 20 CARBON ATOMS, 2-HEPTYL, METHYLOCTYL, OR CYCLOALKYL-LOWER-ALKYL, THE CYCLOALKYL PART HAVING 3 TO 8 CARBON ATOMS, AND X IS LOWER ALKOXY OR STRAIGHT CHAIN ALKANOLOXY OF 2 TO 20 CARBON ATOMS, BENZOYLOXY, NAPHTHOYLOXY, PHOSPHATE, CARBONATE, MALONATE, SUCCINATE, CITRATE, PHOSPHATE, HEMISUCCINATE, OR LOWER ALKYL CARBONATE, EXCLUSIVE OF AMINO ACID ESTERS.

公开(公告)号：US3824244A

公开(公告)日：1974-07-16

申请号：US24635272

申请日：1972-04-21

Applicant: SANDOZ AG

Inventor： HOULIHAN W ,  NADELSON J

IPC: C07D211/22 ,  C07D213/30 ,  C07D455/04 ,  C07D471/04 ,  C07D31/34

CPC classification number: C07D213/30 ,  C07D211/22 ,  C07D455/04 ,  C07D471/04

Abstract: PHENYL AND SUBSTITUTED PHENYL PYRIDO BENZAZEPINES AND BENZOQUINOLIZINES, E.G. 11(4-CHLOROPHENYL)-1,3,4MATETRAHYDRO-2H-BENZO - (B) - QUINOLIZINE-6-(11H)-ONE, AND 12-HYDROXY-12-PHENYL- PYRIDO - (1,2-B)(2) -BENZAZEPIN-6ONE, ARE USEFUL AS MAJOR TRANQUILIZERS.

公开(公告)号：US3806513A

公开(公告)日：1974-04-23

申请号：US31146672

申请日：1972-12-04

Applicant: BEECHAM GROUP LTD

Inventor： BROWN A ,  NAYLER J

IPC: C07D213/55 ,  C07D471/04 ,  C07D31/34

CPC classification number: C07D471/04 ,  C07D213/55

Abstract: A - (3 - BENZOYL-2-METHYLINDOLIZUN-1-YL) PROPIONIC ACID AND ITS PHARMACUTICALLY ACCEPTABLE NON-TOXIC SALTS AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS.

公开(公告)号：US3787424A

公开(公告)日：1974-01-22

申请号：US3787424D

申请日：1972-05-08

Applicant: SHARPS ASS

Inventor： PARS H ,  RAZDAN R

IPC: C07D491/04 ,  C07D491/052 ,  C07D31/34

CPC classification number: C07D491/04

Abstract: WHEREIN R1 IS HYDROGEN LOWERALKANOYL, CYCLOALKYLLOWERALKYL, LOWERALKYL, CYCLOALKYLLOWERALKANOYL, LOWERALKENYL, LOWERALKYNYL, HALOLOWERALKENYL, PHENYLLOWERALKYL, PHENYLLOWERALKENYL OR PHENYLLOWERALKNYL; R2 IS LOWERALKYL; R3 IS C1-C20 ALKYL OR CYCLOALKYLLOWERALKYL; N IS AN INTEGER FROM 1 TO 6; AND R4 IS HYDROGEN OR LOWERALKYL; AND THE PHARMACEUTICALLY ACCEPTALE ACID ADDITION SALTS THEREOF.
TETRAHYDRO-5H-(1)BENZOPYRANO(4,3-C)PYRIDINE

2-R1,5,5-DI(R-),8-R3,10-((R4-)2-N-(CH2)N-COO-)-1,2,3,4-

DIALKYLAMINO ESTERS OF BENZOPYRANOPYRIDINES REPRESENTED BY THE FORMULA

公开(公告)号：US3707474A

公开(公告)日：1972-12-26

申请号：US5985470

申请日：1970-06-26

Applicant: BEECHAM GROUP LTD

Inventor： RAZDAN RAJ K ,  THOMPSON WILLIAM R

IPC: A61K31/35 ,  A61K31/44 ,  C07D405/04 ,  C07F9/58 ,  C07F9/655 ,  C07D31/34

CPC classification number: C07D405/04 ,  A61K31/35 ,  A61K31/44 ,  C07F9/58 ,  C07F9/655

Abstract: NOVEL CHEMICAL COMPOUNDS AND NON-TOXIC ACID ADDITION SALTS THEREOF ARE DISCLOSED WHEREIN THE COMPOUNDS HAVE THE FORMULAS:

2,2,3-TRI(R1-),4-(PYRID-4-YL),5-X,7-R2-CHROMAN (I)

2,2-DI(R1-),4-(PYRID-4-YL),5-X,7-R2-2H-CHROMENE (II)

2-(O=),4-(PYRID-4-YL),5-X,7-R2-2H-CHROMENE (III)

IN WHICH R1 IS LOWER ALKYL HAVING 1 TO 6 CARBON ATOMS, R2 IS ALKYL HAVING 1 TO 20 CARBON ATOMS OR CYCLOALKYLLOWER-ALKYL, THE CYCLOALKYL PART HAVING 3 TO 8 CARBON ATOMS, AND X IS OH OR A PHARMACEUTICALLY ACCEPTABLE SALT INCLUDING AN ALKALI METAL SALT, OR AN ETHER OR ESTER OF THE OHGROUP, EXCLUSIVE OF AMINO ACID ESTERS. COMPOUNDS I AND II POSSESS BENEFICIAL PHARMACODYNAMIC ACTIVITY WITH RESPECT TO THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEM, AND COMPOUNDS III ARE INTERMEDIATES FOR USE IN THE PREPARATION OF COMPOUNDS I AND II.

公开(公告)号：US3631054A

公开(公告)日：1971-12-28

申请号：US3631054D

申请日：1970-01-22

Applicant: DU PONT

Inventor： KAUER JAMES C

IPC: C07D213/55 ,  C07D309/38 ,  C07D31/34

CPC classification number: C07D309/38 ,  C07D213/55

Abstract: 4-AROMTIC BYCYCLO(2.2.2.)OCT-2-ENE-2-CARBOXYLIC ACIDS AND THEIR ESTERS WHICH ARE PREPARED BY THE REACTION OF A 3,6-DISBUSTITUTED A-PYRONE AND ETHYLENE AT ELEVATED TEMPERATURES ARE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF 4-AROMATIC BICYCLO(2.2.2)OCTANE - 1 - AMINES USEFUL AS ANTI-DEPRESSANT.

公开(公告)号：US3555034A

公开(公告)日：1971-01-12

申请号：US3555034D

申请日：1968-06-18

Applicant: AMERICAN HOME PROD

Inventor： DIEBOLD JAMES L ,  WOLF MILTON

IPC: C07D471/04 ,  C07D31/34

CPC classification number: C07D471/04

Abstract: THIS INVENTION CONCERNS 5.6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-2-OL ESTERS WHICH ARE PHARMACOLOGICALLY ACTIVE AS CENTRAL NERVOUS SYSTEM DEPRESSANTS.

公开(公告)号：US3526633A

公开(公告)日：1970-09-01

申请号：US3526633D

申请日：1968-03-06

Applicant: AMERICAN CYANAMID CO

Inventor： GADEKAR SHREEKRISHNA MANMOHAN ,  JOHNSON BERNARD DEAN ,  COHEN ELLIOTT

IPC: C07D487/04 ,  C07D31/34 ,  C07D31/42

CPC classification number: C07D487/04

公开(公告)号：US3442893A

公开(公告)日：1969-05-06

申请号：US3442893D

申请日：1966-05-23

Applicant: ABBOTT LAB

Inventor： LYNCH DON MURL

IPC: C07D213/30 ,  C07D31/34 ,  C07D29/16 ,  C07D31/28

CPC classification number: C07D213/30

公开(公告)号：US3801584A

公开(公告)日：1974-04-02

申请号：US3801584D

申请日：1971-12-27

Applicant: DAICEL LTD

Inventor： KUBO M ,  HORIKAWA T

IPC: C07D213/807 ,  B01J31/00 ,  C07B61/00 ,  C07D213/79 ,  C07D213/803 ,  C07D31/34

CPC classification number: C07D213/803

Abstract: A PROCESS FOR PRODUCING PYRIDINE CARBOXYLIC ACIDS BY OXIDIZLING ALKYL PYRIDINES IN THE LIQUID PHASE WITH A MOLECULAR OXYGEN-CONTAINING GAS IN THE PRESENCE OF A CATALYST CONSISTING OF ZIRCONIUM COMPOUNDS, SALTS OF OTHER TRANSITION METALS AND BROMINE COMPOUNDS.