公开(公告)号：US06605632B1

公开(公告)日：2003-08-12

申请号：US09700056

申请日：2000-11-10

Applicant: Daniel Lesieur ,  Frédérique Klupsch ,  Gérald Guillaumet ,  Marie-Claude Viaud ,  Michel Langlois ,  Caroline Bennejean ,  Pierre Renard ,  Philippe Delagrange

Inventor： Daniel Lesieur ,  Frédérique Klupsch ,  Gérald Guillaumet ,  Marie-Claude Viaud ,  Michel Langlois ,  Caroline Bennejean ,  Pierre Renard ,  Philippe Delagrange

IPC: C07D30785

CPC classification number: C07D207/27 ,  C04B35/632 ,  C07C233/43 ,  C07C233/62 ,  C07C233/65 ,  C07C237/48 ,  C07C271/20 ,  C07C275/24 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/14 ,  C07D209/20 ,  C07D209/60 ,  C07D213/70 ,  C07D221/10 ,  C07D231/12 ,  C07D233/42 ,  C07D233/56 ,  C07D233/84 ,  C07D235/06 ,  C07D249/08 ,  C07D261/20 ,  C07D307/81 ,  C07D307/92 ,  C07D311/58 ,  C07D311/60 ,  C07D319/18 ,  C07D319/20 ,  C07D333/20 ,  C07D333/38 ,  C07D333/58 ,  C07D333/74 ,  C07D335/06 ,  C07D335/08 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the description

Abstract translation: 本发明涉及式（I）化合物：R-A-R'其中：A如说明书中所定义; R代表基团（V），（VI），（VII）或（VIII），其中E，Q，R1，R2，R3，v和R4如说明书中所定义; R'表示 - （CH 2）t -R 5基团，其中t和R 5如说明书中所定义

公开(公告)号：US06274619B1

公开(公告)日：2001-08-14

申请号：US09584136

申请日：2000-05-31

Applicant: Akito Tanaka ,  Hiroaki Mizuno ,  Minoru Sakurai

Inventor： Akito Tanaka ,  Hiroaki Mizuno ,  Minoru Sakurai

IPC: C07D30785

CPC classification number: C07D513/04 ,  C07D307/85 ,  C07D333/70 ,  C07D333/80 ,  Y02P20/55

Abstract: A compound of the formula: in which R1 is hydrogen, optionally substituted lower alkylcarbamoyl(lower)alkylidene, lower alkylidene, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, R2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, R3 is hydrogen or amidino-protective group, A is lower alkylene or carbonyl, X is Y is lower alkylene, —S— or —SO2—, Z is —S— or —O—, and the line: is a single bond or a double bond, or pharmaceutically acceptable salts thereof, which is useful as a medicament.

Abstract translation: 下式化合物：其中R 1为氢，任选取代的低级烷基氨基甲酰基（低级）亚烷基，低级亚烷基，低级烷基，任选取代的芳（低级）烷基，环（低级）烷基（低级）烷基，被保护的羧基 ，羧基（低级）烷基，羟基（低级）烷基，任选取代的低级烷基氨基甲酰基（低级）烷基，低级烷硫基（低级）烷基，羧基（低级）烷酰基，受保护羧基（低级）烷酰基，芳酰基，低级烷酰基或任选取代 芳基氨基甲酰基（低级）烷基，R2是氢，羧基，保护的羧基，甲酰基或N-（低级）烷基-N-（低级）烷氧基氨基甲酰基，R3是氢或脒基保护基，A是低级亚烷基或羰基，X是Y 低级亚烷基，-S-或-SO 2 - ，Z是-S-或-O-，并且行：是 单键或双键，或其药学上可接受的盐，其可用作药物。