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公开(公告)号：US06682596B2
公开(公告)日：2004-01-27
申请号：US10032809
申请日：2001-12-26
IPC分类号： C30B714
CPC分类号： B82Y30/00 , B82Y10/00 , C30B7/00 , C30B29/605 , Y10T117/10
摘要： Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.
摘要翻译： 合成了对反应条件的高度控制，从而在流通反应器中高度控制纳米晶体，其中通过在线检测产物的特征性质并通过相应地调节反应条件来维持反应条件。 以类似的方式实现纳米晶体的涂层。
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2.发明授权Microvolume device employing fluid movement by centrifugal force in different directions 失效采用离心力在不同方向运动的微体积装置公开(公告)号：US06811609B2
公开(公告)日：2004-11-02
申请号：US10061079
申请日：2002-01-29
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： C30B714
CPC分类号： C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004
摘要： A microfluidic device is provided that comprises: a substrate; one or more microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume, a second submicrovolume where fluid in the first submicrovolume is transported to the second submicrovolume when the device is rotated about a first rotational axis, and a third submicrovolume where fluid in the first submicrovolume is transported to the third submicrovolume when the device is rotated about a second, different rotational axis.
摘要翻译： 提供一种微流体装置，其包括：基板; 至少部分地由衬底限定的一个或多个微卷，每个微体积包括第一亚微体积，第二亚微体积，其中第一亚微体积中的流体在装置围绕第一旋转轴线旋转时传输到第二亚微体积，第三亚微体积 当装置围绕第二不同旋转轴线旋转时，第一亚微体积中的流体被运送到第三微量体积。
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3.发明授权Applying x-ray topography and diffractometry to improve protein crystal growth 失效应用x射线形貌和衍射来改善蛋白质晶体生长公开(公告)号：US06468346B2
公开(公告)日：2002-10-22
申请号：US09733068
申请日：2000-12-11
IPC分类号： C30B714
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/901
摘要： This invention is a method for identifying conditions for growing protein crystals giving improved protein crystal growth. Crystals of a protein are grown under different sets of predetermined conditions, and x-ray topographic images of the protein crystals are generated to identify the set(s) of conditions that produce crystals having the fewest crystal defects. In a preferred embodiment, the protein crystals are grown in a dynamically controlled crystallization system. An important condition of crystal growth that can be optimized by the method of the invention is the effective gravity, geff, experienced by the growing crystal; for example, when the crystal is grown in a powerful magnetic field that causes the protein molecules in the growing crystal to experience acceleration of an effective gravitational field that is greater or less than the actual gravitational field at the earth's surface. The method further includes using x-ray crystallography to solve the structure of the protein in a crystal found by x-ray topography to have fewer defects.
摘要翻译： 本发明是鉴定提高蛋白质晶体生长的蛋白质晶体生长条件的方法。 蛋白质的晶体在不同的预定条件下生长，并且产生蛋白质晶体的x射线地形图以鉴定产生具有最少晶体缺陷的晶体的条件的集合。 在优选的实施方案中，蛋白质晶体在动态控制的结晶体系中生长。 可以通过本发明的方法优化的晶体生长的重要条件是生长晶体经历的有效重力，geff; 例如，当晶体在强大的磁场中生长时，使得生长晶体中的蛋白质分子经历加速度大于或小于地球表面的实际重力场的有效引力场。 该方法还包括使用x射线晶体学来解决通过X射线形貌发现的晶体中蛋白质的结构，以减少缺陷。
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公开(公告)号：US06821339B2
公开(公告)日：2004-11-23
申请号：US10181280
申请日：2002-11-18
申请人： Kristian Eriksson , Juha Nurmi , Jouko Virtanen
发明人： Kristian Eriksson , Juha Nurmi , Jouko Virtanen
IPC分类号： C30B714
CPC分类号： C13B30/027 , C07B63/00 , C07D201/16 , C30B7/00
摘要： The invention relates to a process for the crystallization of substances having a narrow metastable supersaturation zone. In the process the saturation of a solution is gradually increased and the solution is seeded for the crystallization. The seeding is performed at a seeding point which is selected in response to a signal received from said process indicating imminent or initial spontaneous nucleation. The process provides a good crystal yield and a crystalline product having a uniform crystal structure and a narrow crystal size distribution.
摘要翻译： 本发明涉及一种具有窄亚稳态过饱和区物质结晶的方法。 在该过程中，溶液的饱和度逐渐增加，并将溶液接种以进行结晶。 在接种点进行播种，该播种点响应于从所述过程接收到的信号而选择，表明即将发生或初始自发成核。 该方法提供了良好的晶体收率和具有均匀晶体结构和窄晶体尺寸分布的晶体产物。
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公开(公告)号：US06818060B2
公开(公告)日：2004-11-16
申请号：US10184037
申请日：2002-06-26
IPC分类号： C30B714
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/90 , Y10T117/10 , Y10T117/1004
摘要： A matrix mixing robot includes a plurality of precision pumps (such as precision syringe pumps), a distributor and a processor system. Each pump, under the control of the processor system, draws an associated stock solution from a stock solution source, and pumps the drawn stock solution out through an outlet. The distributor, also under the control of the processor system, directs a stock solution from a particular pump outlet to a selected solution receptacle. A multi-port distribution valve may be associated with each precision pump. Each valve, under control of the processor system, can connect its associated pump to one the pump's inlets or outlets.
摘要翻译： 矩阵混合机器人包括多个精密泵（例如精密注射泵），分配器和处理器系统。 处理器系统控制下的每个泵从原液解决方案中抽出一个相关的库存解决方案，并通过一个出口将抽出的库存溶液抽出来。 分配器也在处理器系统的控制下，将库存溶液从特定的泵出口引导到选定的溶液容器。 多口分配阀可以与每个精密泵相关联。 处理器系统控制下的每个阀都可以将其相关的泵连接到泵的入口或出口。
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公开(公告)号：US06726765B2
公开(公告)日：2004-04-27
申请号：US10119895
申请日：2002-04-11
申请人： Masaru Uemura
发明人： Masaru Uemura
IPC分类号： C30B714
CPC分类号： C30B7/00 , C30B29/58 , Y10T117/1024
摘要： A protein crystallization apparatus is comprised of a vessel supporting section and a rotating unit. A vessel is detachably fixed to the vessel supporting section. The rotating unit rotates the vessel supporting section around first and second rotation axes. The vessel is comprised of a vessel section having an opening; a sealing section which seals said opening of said vessel section; an absorption member which is provided in the vessel section and in which precipitant solution is absorbed; and a button provided apart from the absorption member to hold protein solution. Precipitant evaporates and diffuses in an inside of the vessel section while the vessel supporting section is rotated. The precipitant is absorbed by the protein solution and a protein crystal is precipitated.
摘要翻译： 蛋白质结晶装置由容器支撑部和旋转部构成。 容器可拆卸地固定到容器支撑部分。 旋转单元围绕第一和第二旋转轴旋转容器支撑部分。 该容器由具有开口的容器部分组成; 密封所述容器部分的所述开口的密封部分; 吸收构件，其设置在容器部中，并且沉淀剂溶液被吸收; 以及与吸收构件分开设置以保持蛋白质溶液的按钮。 沉淀物在容器支撑部分旋转的同时在容器部分的内部蒸发并扩散。 沉淀剂被蛋白质溶液吸收，蛋白质晶体沉淀。
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公开(公告)号：US06811608B1
公开(公告)日：2004-11-02
申请号：US09631185
申请日：2000-08-02
IPC分类号： C30B714
摘要： Disclosed is a system and a method for depositing crystallization observations into a relational database. The system includes a computer, microscope, and a headset having a microphone and headphones. Crystallization observations are deposited into the database by verbal commands. Verbal commands also drive the crystallization apparatus plates to position the apparatus wells within the microscope field of vision. The system is integrated with a software application which enables the user to build the trials, matrices, solutions, and macromolecules to be used in the crystallization trials. The user is guided through the crystallization trial setup by a multitude of managers and builders of the software application. The software application also provides numerous tools to query the database and display results in a multitude of formats.
摘要翻译： 公开了一种用于将结晶观察结果存入关系数据库的系统和方法。 该系统包括具有麦克风和耳机的计算机，显微镜和耳机。 结晶观察通过语言命令存入数据库。 语言命令还驱动结晶装置板将装置孔定位在显微镜视野内。 该系统与软件应用程序集成，使用户能够构建用于结晶试验的试验，矩阵，解决方案和大分子。 用户由软件应用程序的众多经理和构建者引导通过结晶试验设置。 软件应用程序还提供了许多工具来查询数据库并以多种格式显示结果。
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8.发明授权Method for parallel delivery and mixing of fluids by rotating a microfluidic device 失效通过旋转微流体装置并行输送和混合流体的方法公开(公告)号：US06761766B2
公开(公告)日：2004-07-13
申请号：US10060859
申请日：2002-01-29
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： C30B714
CPC分类号： C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004
摘要： A microfluidic method comprising: taking a microfluidic device comprising a substrate, and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume in fluid communication with the first submicrovolume; adding fluids to the first submicrovolumes; and applying a centrifugal force to the device to cause a same volume of fluid to be transported to the second microvolumes from the first submicrovolumes.
摘要翻译： 一种微流体方法，包括：获取包含基底的微流体装置和至少部分地由所述基底限定的多个微体积，每个微体积包含与所述第一亚微体积流体连通的第一亚微体积和第二亚微体积; 将流体添加到第一次微量体积; 以及向所述装置施加离心力，以使相同体积的流体从所述第一微量体积输送到所述第二微量体积。
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公开(公告)号：US06302958B1
公开(公告)日：2001-10-16
申请号：US09492483
申请日：2000-01-27
申请人： Mark D. Lindrud , Soojin Kim , Chenkou Wei
发明人： Mark D. Lindrud , Soojin Kim , Chenkou Wei
IPC分类号： C30B714
CPC分类号： C30B7/10 , B01D9/0036 , B01D9/005 , B01F5/0256 , B01F5/0268 , B01F7/00 , B01F11/0225 , B01F11/0258 , B01F13/0059 , B01F13/1033 , B01J4/001 , B01J19/10 , B01J19/18 , B01J2219/00094 , B01J2219/00164 , C30B7/00 , C30B29/58
摘要： A novel apparatus and process for crystallizing submicron-sized crystals of a pharmaceutical composition. The submicron-sized crystals, which have an average size of less than 1 micron, provide high surface area end product crystals with greatly improved stability and purity, and which afford crystals having improved bioavailability, higher dissolution, decreased decomposition rate and longer shelf-life.
摘要翻译： 用于结晶药物组合物的亚微米尺寸晶体的新型装置和方法。 具有小于1微米平均尺寸的亚微米尺寸晶体提供了高表面积的最终产品晶体，其稳定性和纯度大大提高，并提供具有改善的生物利用度，更高的溶解度，降低的分解速率和更长的保质期的晶体 。
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