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1.发明申请Compositions and Methods for Producing Fermentation Products and Residuals 审中-公开用于生产发酵产品和残留物的组合物和方法公开(公告)号：US20090291469A1
公开(公告)日：2009-11-26
申请号：US11795659
申请日：2007-04-05
申请人： Peter R. David
发明人： Peter R. David
摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified so as to yield a residual having greater value that a residual produced in the process by a microorganism not so modified. In particular, the present invention contemplates using microorganisms in a fermentation process that have been modified to increase production of a nutrient, such as an essential amino acid, thereby reducing the need to supplement the nutrient in the animal's diet. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.
摘要翻译： 本发明提供组合物和方法，其设计用于增加产生用于商业化的第一产物（例如乙醇）的发酵反应的价值产物，以及例如用作动物饲料的发酵残余物。 所述方法涉及在发酵过程中使用微生物进行修饰，从而得到具有较大值的残留物，即微生物在该过程中产生的残留物未被修饰。 特别地，本发明考虑在发酵过程中使用微生物，该发酵过程已被修饰以增加诸如必需氨基酸的营养物质的产生，从而减少补充动物饮食中营养物质的需要。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。
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2.发明申请COMPOSITIONS AND METHODS FOR PRODUCING FERMENTATION PRODUCTS AND RESIDUALS 审中-公开用于生产发酵产品和残留物的组合物和方法公开(公告)号：US20090006280A1
公开(公告)日：2009-01-01
申请号：US12209127
申请日：2008-09-11
申请人： Peter R. David
发明人： Peter R. David
摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.
摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。
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公开(公告)号：US20080216736A1
公开(公告)日：2008-09-11
申请号：US12126824
申请日：2008-05-23
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： H01L21/322
摘要： A microfluidic method is provided that comprises: delivering a first fluid to a first lumen of a microfluidic device and a second, different fluid to a second lumen of the microfluidic device, the first and second lumens sharing a common wall which allows for diffusion between the lumens over at least a portion of the length of the lumens; and having the first and second fluids diffuse between the first and second lumens.
摘要翻译： 提供了一种微流体方法，其包括：将第一流体输送到微流体装置的第一腔，将第二流体递送至微流体装置的第二腔，所述第一和第二流体共享公共壁，其允许在所述微流体装置之间扩散 在流明的长度的至少一部分上的流明; 并且使第一和第二流体在第一和第二腔之间扩散。
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公开(公告)号：US06719840B2
公开(公告)日：2004-04-13
申请号：US09877405
申请日：2001-06-08
申请人： Peter R. David , Nathaniel E. David
发明人： Peter R. David , Nathaniel E. David
IPC分类号： C30B702
CPC分类号： G01N25/147 , B01J2219/00274 , B33Y80/00 , C30B7/00 , C30B29/58 , Y10S117/90 , Y10T117/10 , Y10T117/1008 , Y10T117/1024
摘要： A method is provided for determining crystallization conditions for a material, the method comprising: taking a plurality of different crystallization samples in an enclosed microvolume, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions which vary among the plurality of crystallization samples; allowing crystals of the material to form in plurality of crystallization samples; and identifying which of the plurality of crystallization samples form crystals.
摘要翻译： 提供了一种用于确定材料的结晶条件的方法，所述方法包括：在封闭的微体积中取多个不同的结晶样品，所述多个结晶样品包含待结晶的材料和在多个结晶样品中变化的结晶条件 ; 允许在多个结晶样品中形成材料的晶体; 并确定多个结晶样品中的哪一个形成晶体。
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5.发明申请Compositions and Methods for Producing Fermentation Products and Residuals 审中-公开用于生产发酵产品和残留物的组合物和方法公开(公告)号：US20110269185A1
公开(公告)日：2011-11-03
申请号：US13095255
申请日：2011-04-27
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： C12P1/00 , C12P7/64 , C12P13/04 , C12P13/08 , C12P13/12 , C12N1/13 , C12P13/06 , C12P13/24 , C12P1/04 , C12N1/19 , C12N1/21 , C12P21/00 , C12P13/22
摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified so as to yield a residual having greater value that a residual produced in the process by a microorganism not so modified. In particular, the present invention contemplates using microorganisms in a fermentation process that have been modified to increase production of a nutrient, such as an essential amino acid, thereby reducing the need to supplement the nutrient in the animal's diet. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.
摘要翻译： 本发明提供组合物和方法，其设计用于增加产生用于商业化的第一产物（例如乙醇）的发酵反应的价值产物，以及例如用作动物饲料的发酵残余物。 所述方法涉及在发酵过程中使用微生物进行修饰，从而得到具有较大值的残留物，即微生物在该过程中产生的残留物未被修饰。 特别地，本发明考虑在发酵过程中使用微生物，该发酵过程已被修饰以增加诸如必需氨基酸的营养物质的产生，从而减少补充动物饮食中营养物质的需要。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。
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公开(公告)号：US20080158543A1
公开(公告)日：2008-07-03
申请号：US11838114
申请日：2007-08-13
申请人： Robert Puskas , Richard A. Livingston , Douglas D. Held , Barbara Klein , Noelle Fukushima , Robert Freese , Philippe J. Goix , Peter R. David , Mickey Urdea
发明人： Robert Puskas , Richard A. Livingston , Douglas D. Held , Barbara Klein , Noelle Fukushima , Robert Freese , Philippe J. Goix , Peter R. David , Mickey Urdea
CPC分类号： G01N35/1095 , G01N1/28 , G01N15/1459 , G01N21/6428 , G01N27/447 , G01N33/68 , G01N33/6803 , G01N33/6845 , G01N2015/1438 , G01N2035/1034
摘要： The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要翻译： 本发明包括分析仪和分析仪系统，其包括单个粒子分析仪，使用分析仪和分析仪系统来分析样品的单颗粒或多颗粒（多路复用）的方法，基于使用分析仪进行生意的方法或 系统的分析器系统和用于存储在本发明的分析器和分析器系统中有用的参数的电子介质。
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公开(公告)号：US07014705B2
公开(公告)日：2006-03-21
申请号：US10060872
申请日：2002-01-29
申请人： Peter R. David
发明人： Peter R. David
CPC分类号： C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004 , Y10T117/1008
摘要： A microfluidic method is provided that comprises: delivering a first fluid to a first lumen of a microfluidic device and a second, different fluid to a second lumen of the microfluidic device, the first and second lumens sharing a common wall which allows for diffusion between the lumens over at least a portion of the length of the lumens; and having the first and second fluids diffuse between the first and second lumens.
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公开(公告)号：US06872250B2
公开(公告)日：2005-03-29
申请号：US10060853
申请日：2002-01-29
申请人： Peter R. David , Nathaniel E. David
发明人： Peter R. David , Nathaniel E. David
CPC分类号： G01N25/147 , B01J2219/00274 , B33Y80/00 , C30B7/00 , C30B29/58 , Y10S117/90 , Y10T117/10 , Y10T117/1008 , Y10T117/1024
摘要： A method for determining crystallization conditions for a material, the method comprising: taking a microfluidic device comprising one or more lumens having microvolume dimensions and a plurality of different crystallization samples within the one or more lumens, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions that vary among the plurality of crystallization samples; transporting the plurality of different crystallization samples within the lumens; and identifying a precipitate or crystal formed in the one or more lumens.
摘要翻译： 一种用于确定材料的结晶条件的方法，所述方法包括：获取包含一个或多个具有微体积尺寸的内腔和在所述一个或多个腔内的多个不同结晶样品的微流体装置，所述多个结晶样品包括待 在多个结晶样品中变化的结晶和结晶条件; 在腔内输送多个不同的结晶样品; 以及鉴定在所述一个或多个内腔中形成的沉淀物或晶体。
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9.发明授权Microfluidic method employing delivery of plural different fluids to same lumen 失效使用多种不同流体输送到相同内腔的微流体方法公开(公告)号：US06797056B2
公开(公告)日：2004-09-28
申请号：US10060955
申请日：2002-01-29
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： C30B902
CPC分类号： C30B7/00 , B01J2219/00274 , B33Y80/00 , C30B29/58 , G01N25/147 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： A microfluidic method is provided that comprises: delivering first and second fluids to a lumen of a microfluidic device such that the first and second fluids flow adjacent to each other within the lumen without mixing except for diffusion at an interface between the first and second fluids, wherein the first fluid is different than the second fluid.
摘要翻译： 提供了一种微流体方法，其包括：将第一和第二流体输送到微流体装置的内腔，使得第一和第二流体在腔内彼此相邻流动而不混合，除了在第一和第二流体之间的界面处的扩散， 其中所述第一流体不同于所述第二流体。
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10.发明申请Compositions and Methods for Producing Fermentation Products and Residuals 审中-公开用于生产发酵产品和残留物的组合物和方法公开(公告)号：US20110223284A1
公开(公告)日：2011-09-15
申请号：US12904947
申请日：2010-10-14
申请人： Peter R. David
发明人： Peter R. David
IPC分类号： A23K1/16 , C12P21/00 , C12P13/08 , C12P13/12 , C12P13/22 , C12P13/06 , C12P13/10 , C12P13/24 , C12P13/00 , C12P1/00 , C12P1/04 , C12P1/02 , C12N1/00
摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.
摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。
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