公开(公告)号：US06608679B1

公开(公告)日：2003-08-19

申请号：US09467184

申请日：1999-12-20

Applicant: Jingkuang Chen ,  Joel A. Kubby

Inventor： Jingkuang Chen ,  Joel A. Kubby

IPC: G01J336

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/2803

Abstract: A micro spectrophotometer is monolithically constructed on a silicon substrate. The spectrophotometer includes a concave grating, which is used for dispersing optical waves as well as focusing reflected light onto a photodiode array sited on a silicon bridge. The silicon bridge is bent 90° from the surface of the silicon substrate in order to orthogonally intersect the output light from the grating. A precision notch is defined in the silicon substrate for coupling to an optical input fiber. Signal processing circuitry is etched on the substrate using conventional CMOS processes for initial processing of information received from the photodiode array.

Abstract translation: 微型分光光度计在硅衬底上单片构造。 分光光度计包括凹光栅，其用于分散光波以及将反射光聚焦到位于硅桥上的光电二极管阵列上。 硅桥从硅衬底的表面弯曲90°，以便与光栅的输出光正交相交。 在硅衬底中限定了用于耦合到光输入光纤的精密凹口。 使用常规CMOS工艺在衬底上蚀刻信号处理电路，用于对从光电二极管阵列接收的信息进行初始处理。

公开(公告)号：US06690466B2

公开(公告)日：2004-02-10

申请号：US09921040

申请日：2001-08-02

Applicant: Peter J. Miller ,  Clifford C. Hoyt

Inventor： Peter J. Miller ,  Clifford C. Hoyt

IPC: G01J336

CPC classification number: G01J3/02 ,  G01J1/08 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/465 ,  G01J3/50 ,  G01J3/501 ,  G01J2003/467 ,  G01N21/31

Abstract: An imaging system is disclosed comprising an illuminator which produces illumination of any desired pure wavelength or of any selected mixture of pure wavelengths simultaneously, which illuminates a sample without spatio-spectral artifacts using illumination optics designed for that purpose; imaging optics, which form an image of the sample at a detector or viewing port; and a detector. This enables imaging the complete spectral image cube for a sample by taking sequential images while illuminating with a series of pure wavelengths, with greater ease and economy than by means of tunable filters, interferometers and the like. It further enables imaging while the sample is illuminated with a precisely controlled mixture of illuminant wavelengths, so that the image presented to the detector is a linear superposition of the sample properties at many wavelengths. This enables taking images of a sample' that directly measure the weighted spectral properties such as projection pursuit vectors, principal components, and the like. Data acquisition is enormously simplified, and speed is increased by one to two orders of magnitude over existing techniques. This is of great benefit in pathology, immunohistochemistry, Pap smear analysis, endoscopy, counterfeit detection, quality control, and other areas where one wishes to measure a spectral index of a living or inert sample.

Abstract translation: 公开了一种成像系统，其包括照明器，该照明器同时产生任何所需纯波长或任何选定的纯波长混合物的照明，其使用为此目的设计的照明光学器件而不使用空间光谱伪像照亮样品; 成像光学器件，其在检测器或观察端口处形成样品的图像; 和检测器。 这使得通过采用一系列纯波长的照射，通过采用顺序图像来成像样品的完整光谱图像立方体，比通过可调滤波器，干涉仪等更容易和经济地进行照射。 当采用精确控制的发光体波长的混合物照射样品时，它进一步实现成像，使得呈现给检测器的图像是许多波长处的样品特性的线性叠加。 这使得能够拍摄直接测量加权光谱特性的样本的图像，例如投影追踪矢量，主成分等。 数据采集​​大大简化，速度比现有技术提高了一到二个数量级。 这在病理学，免疫组织化学，巴氏涂片分析，内窥镜检查，假冒检测，质量控制以及其他希望测量活体或惰性样品的光谱指数的领域是非常有益的。

公开(公告)号：US06683685B2

公开(公告)日：2004-01-27

申请号：US10000097

申请日：2001-12-04

Applicant: Masumi Sakai

Inventor： Masumi Sakai

IPC: G01J336

CPC classification number: G01J3/30 ,  G01J1/18 ,  G01J3/32 ,  G01J3/42 ,  G01N21/3103

Abstract: In an atomic absorption photometer, depending on a fact whether a background correction is carried out or not, a pattern of a pulse lighting of light sources and a timing of sampling a light receiving signal are changed. Namely, at the time of a background correction measurement, one cycle is divided into three periods, that is, a period of lighting HCL, a period of lighting D2L, and an off period, and at the time of a measurement without a background correction, one cycle is divided into the period of lighting HCL and the off period. Accordingly, at the time of the measurement without the background correction, the period of lighting HCL and the off period become longer, and signal-to-noise ratio of the light receiving signal is improved. Accordingly, an absorbance with high accuracy can be calculated.

Abstract translation: 在原子吸收光度计中，根据是否执行背景校正的事实，改变光源的脉冲发光的模式和对光接收信号进行采样的定时。 也就是说，在背景校正测量时，将一个周期分为三个周期，即点亮时间HCL，点亮时间D2L和关闭周期，以及在没有背景校正的测量时 ，一个周期分为照明期间HCL和关闭期间。 因此，在没有背景校正的测量时，点亮HCL和关闭周期变长，并且提高了光接收信号的信噪比。 因此，可以计算出高精度的吸光度。

公开(公告)号：US06373568B1

公开(公告)日：2002-04-16

申请号：US09633417

申请日：2000-08-07

Applicant: Peter J. Miller ,  Clifford C. Hoyt

Inventor： Peter J. Miller ,  Clifford C. Hoyt

IPC: G01J336

CPC classification number: G01J3/02 ,  G01J1/08 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/465 ,  G01J3/50 ,  G01J3/501 ,  G01J2003/467 ,  G01N21/31

Abstract: An imaging system is disclosed comprising an illuminator which produces illumination of any desired pure wavelength or of any selected mixture of pure wavelengths simultaneously, which illuminates a sample without spatio-spectral artifacts using illumination optics designed for that purpose; imaging optics, which form an image of the sample at a detector or viewing port; and a detector. This enables imaging the complete spectral image cube for a sample by taking sequential images while illuminating with a series of pure wavelengths, with greater ease and economy than by means of tunable filters, interferometers and the like. It further enables imaging while the sample is illuminated with a precisely controlled mixture of illuminant wavelengths, so that the image presented to the detector is a linear superposition of the sample properties at many wavelengths. This enables taking images of a sample that directly measure the weighted spectral properties such as projection pursuit vectors, principal components, and the like. Data acquisition is enormously simplified, and speed is increased by one to two orders of magnitude over existing techniques. This is of great benefit in pathology, immunohistochemistry, Pap smear analysis, endoscopy, counterfeit detection, quality control, and other areas where one wishes to measure a spectral index of a living or inert sample.

Abstract translation: 公开了一种成像系统，其包括照明器，该照明器同时产生任何所需纯波长或任何选定的纯波长混合物的照明，其使用为此目的设计的照明光学器件而不使用空间光谱伪像照亮样品; 成像光学器件，其在检测器或观察端口处形成样品的图像; 和检测器。 这使得通过采用一系列纯波长的照射，通过采用顺序图像来成像样品的完整光谱图像立方体，比通过可调滤波器，干涉仪等更容易和经济地进行照射。 当采用精确控制的发光体波长的混合物照射样品时，它进一步实现成像，使得呈现给检测器的图像是许多波长处的样品特性的线性叠加。 这使得能够拍摄直接测量加权光谱特性的样本的图像，例如投影追踪矢量，主成分等。 数据采集​​大大简化，速度比现有技术提高了一到二个数量级。 这在病理学，免疫组织化学，巴氏涂片分析，内窥镜检查，假冒检测，质量控制以及其他希望测量活体或惰性样品的光谱指数的领域是非常有益的。

公开(公告)号：US06249346B1

公开(公告)日：2001-06-19

申请号：US09467185

申请日：1999-12-20

Applicant: Jingkuang Chen ,  Joel A. Kubby

Inventor： Jingkuang Chen ,  Joel A. Kubby

IPC: G01J336

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/2803

Abstract: A micro spectrophotometer is monolithically constructed on a silicon substrate. The spectrophotometer includes a concave grating, which is used for dispersing optical waves as well as focusing reflected light onto a photodiode array sited on a silicon bridge. The silicon bridge is bent 90° from the surface of the silicon substrate in order to orthogonally intersect the output light from the grating. A precision notch is defined in the silicon substrate for coupling to an optical input fiber. Signal processing circuitry is etched on the substrate using conventional CMOS processes for initial processing of information received from the photodiode array.

Abstract translation: 微型分光光度计在硅衬底上单片构造。 分光光度计包括凹光栅，其用于分散光波以及将反射光聚焦到位于硅桥上的光电二极管阵列上。 硅桥从硅衬底的表面弯曲90°，以便与光栅的输出光正交相交。 在硅衬底中限定了用于耦合到光输入光纤的精密凹口。 使用常规CMOS工艺在衬底上蚀刻信号处理电路，用于对从光电二极管阵列接收的信息进行初始处理。