公开(公告)号：US20220283116A1

公开(公告)日：2022-09-08

申请号：US17632613

申请日：2020-08-03

Applicant: King Abdullah University of Science and Technology

Inventor： Shofarul Wustoni ,  Sahika Inal

IPC: G01N27/414 ,  G01N27/327 ,  G01N27/333 ,  G01N27/31 ,  G01N27/447

Abstract: Devices for detecting an analyte in a sample suspected of containing the analyte, are provided. The devices include bio-functional, nanostructured, isoporous membranes (BNIM) integrated organic electrochemical transistor (OECT), herein BNIM-OECT, for the rapid and sensitive detection of the presence of an analyte of interest, in a sample, for example, a biological sample. The membrane (i.e., BNIM) is physically separated from the OECT channel therefore the electronic device can be used multiple times. The isoporous membrane is functionalized to include a binding partner for the analyte being detected. The BNIM-OECT can be used for disease detection, by functionalizing the BNIM-OECT with a binding partner to an analyte associated with the disease, applying a collected biological sample to the BNIM-OECT. A decrease in channel current as a result of analyte binding to its binding partner on the isoporous membrane indicates the presence of the analyte in the sample.

公开(公告)号：US10830690B2

公开(公告)日：2020-11-10

申请号：US15615007

申请日：2017-06-06

Applicant: Endress+Hauser Conducta GmbH+Co. KG

Inventor： Erik Hennings ,  Jens Vettermann ,  Andreas Löbbert

IPC: G01N21/01 ,  G01N27/31 ,  G01N27/26

Abstract: The present disclosure relates to a method for manufacturing a sensor cap with at least one main body and a membrane for an optochemical or electrochemical sensor for determining and/or monitoring the concentration of an analyte in a measuring medium, a corresponding sensor cap, and a corresponding sensor. In one aspect of the present disclosure, a permeable membrane is provided with a surface for contacting the measuring medium, as well as a main body with at least one sector for connecting to the membrane. At least part of the membrane and main body are welded, wherein the membrane is at least partially applied to the at least one sector of the main body and a connection between the main body and membrane is sealed against the measuring medium.

公开(公告)号：US10724066B2

公开(公告)日：2020-07-28

申请号：US16068877

申请日：2017-01-27

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Jeffrey LaBelle ,  Chi Lin ,  Jonus Reyna ,  Amnah Alkhan ,  Cael Muggeridge ,  Susan Sheffield

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/403 ,  G01N27/70 ,  G01N27/31 ,  A61B5/145

Abstract: Devices and methods capable of detecting glucose in saliva (FIG. 12). The devices feature a sensor having a substrate containing electrodes and one or more reagents on the electrodes. A detection device is operably coupled with the sensor to detect glucose based on measurement of an electrical parameter when electricity is applied to the electrode.

公开(公告)号：US20160245775A1

公开(公告)日：2016-08-25

申请号：US14626092

申请日：2015-02-19

Applicant: Palo Alto Research Center Incorporated

Inventor： Craig Eldershaw ,  Saroj Sahu ,  Sean Garner ,  Ranjeet Rao ,  Ashutosh Kole ,  Vedasri Vedharathinam ,  Divyaraj Desai ,  Jessica Louis Baker Rivest ,  Richard Steele ,  Martin J. Sheridan

IPC: G01N27/333 ,  G01N27/31

CPC classification number: G01N27/333 ,  B07C5/344 ,  B07C2501/0036 ,  B07C2501/0054 ,  G01N27/31 ,  G01N27/403 ,  G01N27/416 ,  G01N33/20

Abstract: Disclosed is an electrochemical probe system and an electrical excitation method, configured in a bulk sorting system, and used to identify the composition of metals and alloys.

Abstract translation: 公开了一种电化学探针系统和电激励方法，其构造成批量分选系统，并用于识别金属和合金的组成。

公开(公告)号：US20160178564A1

公开(公告)日：2016-06-23

申请号：US14970794

申请日：2015-12-16

Applicant: Endress + Hauser Condcta Gesellschaft für Mess-und Regeltechnik mbH + Co. KG

Inventor： Magdalena Losik ,  Thomas Wilhelm

IPC: G01N27/406 ,  G01N27/401 ,  G01N27/416 ,  G01N27/31

CPC classification number: G01N27/31

Abstract: The invention relates to an electrochemical half cell comprising: a housing, a potential sensing element, which is at least partially arranged within the housing and is electrically conductively connected to an electrical terminal pad arranged outside the housing; and an electrolyte that is solidified and arranged within the housing, wherein a plurality of gas bubbles which are in particular uniformly distributed within the volume occupied by the electrolyte, are trapped in the electrolyte.

Abstract translation: 本发明涉及一种电化学半电池，包括：壳体，电位感测元件，其至少部分地布置在壳体内并且电连接到布置在壳体外部的电端子垫; 以及固化并布置在壳体内的电解质，其中特别均匀地分布在由电解质占据的体积内的多个气泡被捕获在电解质中。

公开(公告)号：US07025871B2

公开(公告)日：2006-04-11

申请号：US10361708

申请日：2003-02-06

Applicant: Scott T. Broadley ,  Steven R. Ragsdale ,  Herbert P. Silverman

Inventor： Scott T. Broadley ,  Steven R. Ragsdale ,  Herbert P. Silverman

IPC: G01N27/31

CPC classification number: G01N27/401 ,  G01N27/30

Abstract: A flowing junction reference electrode exhibiting heretofore unattainable potentiometric characteristics is described, comprising a microfluidic liquid junction member that is situated between a reference electrolyte solution and a sample solution. This microfluidic liquid junction member has an array of nanochannels spanning the member and physically connecting the reference electrolyte solution and a sample solution, but while the electrolyte solution flows through the array of nanochannels and into the sample solution at a linear velocity, the sample solution does not substantially enter the array of nanochannels via the mechanisms of diffusion, migration, convection or other known mechanisms. The number of nanochannels in the array is preferably between approximately 108 and approximately 100. Also preferably, the nanochannels are substantially straight and are substantially parallel to one another; such an array of nanochannels is herein described as anisotropic. The nanochannels are also preferably coated. The widths of any nanochannels in the array of nanochannels are preferably uniform, in that the width of any nanochannel is substantially equal to the width of any other nanochannels in the array. The nanochannels preferably have widths of greater than approximately 1 nanometer and less than approximately 500 nanometers, and most preferably of 70 nanometers. The electrode may be constructed out of any suitable material, and is preferably is constructed of a polymer, most preferably a polymer selected from the group consisting of polycarbonate and polyimide, and may also preferably be constructed of silicon, glass, or ceramic.

Abstract translation: 描述了迄今无法实现的电位特性的流动接合参考电极，其包括位于参考电解质溶液和样品溶液之间的微流体液体接合部件。 该微流体液接合部件具有横跨该部件的纳米通道的阵列并物理连接参考电解质溶液和样品溶液，但是当电解质溶液以线速度流过纳米通道阵列并进入样品溶液时，样品溶液 通过扩散，迁移，对流或其他已知机制的机制基本上不进入纳米通道阵列。 阵列中的纳米通道的数量优选在约10 -8至约100之间。还优选地，纳米通道基本上是直的并且基本上彼此平行; 这种纳米通道阵列在此被描述为各向异性。 纳米通道也优选地被涂覆。 纳米通道阵列中的任何纳米通道的宽度优选是均匀的，因为任何纳米通道的宽度基本上等于阵列中任何其它纳米通道的宽度。 纳米通道优选具有大于约1纳米且小于约500纳米，最优选70纳米的宽度。 电极可以由任何合适的材料制成，并且优选由聚合物构成，最优选由聚碳酸酯和聚酰亚胺组成的组中选择的聚合物构成，并且还优选由硅，玻璃或陶瓷构成。

公开(公告)号：US06964734B2

公开(公告)日：2005-11-15

申请号：US09818750

申请日：2001-03-27

Applicant: Geun Sig Cha ,  Gang Cui ,  Jina Yoo ,  Joung Su Lee ,  Hakhyun Nam

Inventor： Geun Sig Cha ,  Gang Cui ,  Jina Yoo ,  Joung Su Lee ,  Hakhyun Nam

IPC: G01N27/31 ,  G01N27/30

CPC classification number: G01N27/301

Abstract: The present invention disclose a method for fabricating planar reference electrodes. Particularly, the present invention relates to the planar reference electrode comprising plate (4); electrode connection (1); electrode (3); insulating membrane (2); inner reference solution (5); junction (7 or 9); and protecting membrane (6, 8 or 9), and processes for fabrication thereof, in which the junction is composed of porous material such as cotton thread, glass fiber, cellulose nitrate, cellulose acetate, filter paper and any material that can produce capillary action; porous polymer membrane; or a capillary either directly printed on the substrate or inserted with a thin film. The planar reference electrode of the present invention exhibit stable electric potential and short activation period, and may be used in both potentiometry and voltammetry. The planar reference electrodes of the present invention can be easily miniaturized and mass produced.

Abstract translation: 本发明公开了一种制造平面参考电极的方法。 特别地，本发明涉及包括板（4）的平面参考电极; 电极连接（1）; 电极（3）; 绝缘膜（2）; 内参照溶液（5）; 交界处（7或9）; 和保护膜（6,8或9）及其制造方法，其中接合处由多孔材料如棉线，玻璃纤维，硝酸纤维素，乙酸纤维素，滤纸以及可产生毛细作用的任何材料组成 ; 多孔聚合物膜; 或直接印刷在基底上或插入薄膜的毛细管。 本发明的平面参考电极表现出稳定的电位和较短的激活期，并且可以用于电位法和伏安法。 本发明的平面参考电极可以容易地小型化并批量生产。

公开(公告)号：US5863400A

公开(公告)日：1999-01-26

申请号：US727504

申请日：1997-02-24

Applicant: Humphrey John Jardine Drummond ,  Thomas William Beck

Inventor： Humphrey John Jardine Drummond ,  Thomas William Beck

IPC: G01N27/28 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/31 ,  G01N27/327 ,  G01N27/40 ,  G01N27/26

CPC classification number: C12Q1/004 ,  C12Q1/001

Abstract: An electrochemical cell comprises a porous membrane (8) of electrically insulating composition, the membrane having pores (not illustrated) communicating from one side of the membrane to another, a working electrode (5) disposed on one side and a counter or pseudo-reference electrode (7) disposed on the other side. A target area (11) of one electrode is liquid permeable and extends over the surface of membrane (8) without blocking underlying pores of the membrane. Optional insulating layers (9,10) cover the electrodes (5,7) and opening defines the target area (11). Preferably, the porous membrane is impregnated with reagents, for example GOD/Ferricyanide.

Abstract translation: PCT No.PCT / AU95 / 00207 Sec。 371日期1997年2月24日 102（e）日期1997年2月24日PCT提交1995年4月12日PCT公布。 出版物WO95 / 28634 日期1995年10月26日电化学电池包括电绝缘组合物的多孔膜（8），所述膜具有从膜的一侧连通到另一侧的孔（未示出），设置在一侧的工作电极（5） 计数器或伪参考电极（7）。 一个电极的目标区域（11）是液体可渗透的并且在膜（8）的表面上延伸而不阻挡膜的下面的孔。 可选绝缘层（9,10）覆盖电极（5,7），开口限定目标区域（11）。 优选地，多孔膜用试剂浸渍，例如GOD /铁氰化物。

公开(公告)号：US11719667B2

公开(公告)日：2023-08-08

申请号：US16668194

申请日：2019-10-30

Applicant: City University of Hong Kong

Inventor： A. L. Roy Vellaisamy ,  Chi Kong Terrence Lau ,  Lin Oo Saw

IPC: G01N27/31 ,  G01N33/574 ,  B01L3/00

CPC classification number: G01N27/31 ,  B01L3/502707 ,  G01N33/57446 ,  G01N33/57492

Abstract: An electrochemical detector includes: a solution chamber and a substance selection structure separating the chamber into individual compartments, wherein the solution chamber is arranged to retain and separate solutions in each of the individual compartments; and a pair of electrodes each connecting the respective individual compartment, wherein the pair of electrodes is arranged to form a conductive path across the electrodes when in contact with the solutions retained in the solution chamber. The substance selection structure is arranged to interact with a target substance in the solution so as to alter an electrical characteristic of the conductive path defined by the pair of electrodes, the solution retained in the individual compartments in the solution chamber and the substance selection structure.

公开(公告)号：US11585780B2

公开(公告)日：2023-02-21

申请号：US16901411

申请日：2020-06-15

Applicant: Endress+Hauser Conducta GmbH+Co. KG

Inventor： Michael Hanko ,  Thomas Wilhelm ,  Matthäus Speck ,  Detlev Wittmer ,  Manfred Jagiella

IPC: G01N27/403 ,  G01N27/40 ,  G01N27/327 ,  G01N27/333 ,  G01N27/31 ,  G01N27/36

Abstract: The present disclosure relates to a potentiometric probe for measuring a measured variable that represents an ion concentration in a measuring medium, including a probe base including a sensor circuit, and two electrochemical half-cells arranged such that one of the half-cells surrounds at least one portion of the other half-cell, wherein at least one of the half-cells is configured as a module which is connected to the probe base via a mechanical and electrical interface. In another embodiment, one of the half-cells is a measuring half-cell including an ion-selective membrane and a terminal lead which electrically contacts the ion-selective membrane. The other half-cell is a reference half-cell, wherein the measuring half-cell and/or the reference half-cell are each configured as a module which is connected to the probe base via a mechanical and electrical interface.