公开(公告)号：US20240222104A1

公开(公告)日：2024-07-04

申请号：US18684195

申请日：2022-08-16

申请人： DH Technologies Development Pte. Ltd.

发明人： Stanislaw POTYRALA ,  Bradley B. SCHNEIDER ,  Leigh BEDFORD

IPC分类号： H01J49/04 ,  H01J49/06 ,  H01J49/16

CPC分类号： H01J49/044 ,  H01J49/045 ,  H01J49/067 ,  H01J49/165

摘要： A curtain chamber includes an orifice plate defining an orifice plate bore. A curtain plate is disposed adjacent to the orifice plate and defines a curtain plate bore. The orifice plate bore is disposed adjacent the curtain plate bore. A biasing element includes a first portion disposed in the orifice plate bore and a second portion disposed in the curtain plate bore. The biasing element biases the curtain plate towards the orifice plate. A race is defined by at least one of the orifice plate and the curtain plate. The race defines a race depth. A seal is disposed in the race. The seal includes an uncompressed seal depth greater than the race depth and a compressed seal depth less than the uncompressed seal depth.

公开(公告)号：US20230143849A1

公开(公告)日：2023-05-11

申请号：US18149468

申请日：2023-01-03

申请人： Micromass UK Limited

发明人： Zoltán TAKÁTS ,  Frances BOLT ,  Tamás KARANCSI ,  Emrys JONES ,  Keith RICHARDSON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Julia BALOG ,  Steven Derek PRINGLE ,  Daniel SIMON

IPC分类号： H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26

CPC分类号： H01J49/049 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/6848 ,  H01J49/0036 ,  H01J49/0404 ,  H01J49/0459 ,  H01J49/068 ,  H01J49/16 ,  H01J49/044 ,  G01N27/623 ,  A61B90/13 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B17/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/1445 ,  A61B18/1815 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6851 ,  G01N33/92 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/025 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/10 ,  H01J49/14 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00

摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

公开(公告)号：US20160225601A1

公开(公告)日：2016-08-04

申请号：US15022396

申请日：2014-09-17

申请人： MICROMASS UK LIMITED

发明人： Stevan Bajic ,  David Gordon ,  Daniel James Kenny ,  Richard Barrington Moulds ,  Stephen O'Brien ,  Ian Trivett ,  Kate Whyatt

IPC分类号： H01J49/16 ,  H01J49/00 ,  H01J49/04

CPC分类号： H01J49/167 ,  H01J49/0027 ,  H01J49/044 ,  H01J49/165

摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≧100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

摘要翻译： 公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体，其中所述气体锥体具有沿x轴布置的第一纵向轴线和电喷雾离子源，所述电喷雾离子源包括具有出口的第一毛细管， 第二纵向轴线和围绕第一毛细管的第二毛细管。 质谱仪还包括去溶剂化气体供应管和第一装置，其布置并适于经由第一毛细管供应分析物液体，使得液体以>200μL/ min的流速离开第一毛细管的出口。 所述质谱仪还包括第二装置，其布置并适于经由所述第二毛细管以80-150L / hr的流速提供喷雾器气体，其中所述第一毛细管的出口以距离x mm 沿着从气体入口孔的中心测量的沿x轴的距离，沿着y轴的距离ymm，从气体锥入口孔的中心测量，并且沿z轴的距离z mm，从 气锥入口孔的中心。 x轴，y轴和z轴相互正交。 去溶剂化气体供应管围绕第二毛细管并且质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体， 并且适于将去溶剂化气体加热至≥100℃的温度;以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体供应锥形气体，并且其中x在 范围2.0-5.0mm，并且其中z / x的比率在1-5:1的范围内。

公开(公告)号：US20140131570A1

公开(公告)日：2014-05-15

申请号：US14127117

申请日：2012-04-09

申请人： Shinji Yoshioka ,  Hiroyuki Yasuda

发明人： Shinji Yoshioka ,  Hiroyuki Yasuda

IPC分类号： H01J49/10

CPC分类号： H01J49/10 ,  G01N30/7266 ,  H01J49/044 ,  H01J49/049

摘要： The purpose of the present invention is to provide a mass spectrometer with high detection sensitivity to generate fine charged droplets and thereby improve the efficiency of sample ionization, and to reduce large droplets with high ionic strength. The present invention includes: liquid chromatograph separating means that separates a sample solution into components; a sample sprayer that sprays as droplets the sample solution separated and eluted by the liquid chromatograph separating means; ion generating means that charges the droplets and generates ions; a mass spectrometer that receives the ions and performs mass spectrometry on the ions; and a desolvation unit that removes a solvent contained in the charged droplets, wherein the desolvation unit includes a desolvation flow path chamber through which the charged droplets pass, heating means for heating the desolvation flow path chamber, and a helical droplet flow path formed in the desolvation flow path chamber.

摘要翻译： 本发明的目的是提供具有高检测灵敏度的质谱仪，以产生精细的带电液滴，从而提高样品电离的效率，并且以高离子强度减少大的液滴。 本发明包括：将样品溶液分离成成分的液相色谱分离装置; 用液体色谱仪分离装置分离和洗脱的样品溶液作为液滴喷雾的样品喷雾器; 离子产生装置，其对液滴充电并产生离子; 接收离子并对离子进行质谱分析的质谱仪; 以及去除溶剂化单元，其去除带电液滴中所含的溶剂，其中去溶剂化单元包括带电液滴通过的去溶剂化流路室，用于加热去溶剂化流路室的加热装置和形成在 去溶剂流路室。

公开(公告)号：US08698075B2

公开(公告)日：2014-04-15

申请号：US13114869

申请日：2011-05-24

申请人： Ruwan T. Kurulugama ,  Mikhail E. Belov

发明人： Ruwan T. Kurulugama ,  Mikhail E. Belov

IPC分类号： H01J49/06

CPC分类号： H01J49/065 ,  H01J49/0404 ,  H01J49/044

摘要： An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.

摘要翻译： 描述了一种正交离子注入装置和方法，其中离子通过位于离子导向器一侧的入口直接注入垂直于离子引导轴的离子导向器中。 加热的毛细管的末端放置在离子导向器内，使得离子直接注入到离子导向器内的DC和RF场中，这有效地将离子限制在离子导向器内。 由电离源产生的通过毛细管进入离子导向器的液滴通过强力的定向气流从离子导向器的相反侧的入口开口从离子导向器移除。 强直流和射频场将离子转移到离子导向器中。 导向正交注入产生比现有技术中已知的常规在线注入低1.5至2倍的噪声电平。 在相同的处理条件下，与常规的直线注入相比，低m / z离子的信号强度更大。

公开(公告)号：US20140061500A1

公开(公告)日：2014-03-06

申请号：US13602249

申请日：2012-09-03

申请人： Zicheng YANG ,  Roy P. MOELLER ,  Stephen ZANON

发明人： Zicheng YANG ,  Roy P. MOELLER ,  Stephen ZANON

IPC分类号： H01J27/02 ,  H01J27/24

CPC分类号： H01J49/044 ,  H01J49/165 ,  H01J49/168 ,  H01J49/24

摘要： An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.

摘要翻译： 使用电喷雾电离，化学电离或光电离原理的大气压离子源包括用于将液体喷射到电离室中的喷射探针，并具有排气口，残留的喷雾和废气如蒸发 溶剂，萃取。 离子源还包括排气系统，其包括连接到排气口的导管。 导管在排气口下游的点处具有从第一横截面到第二横截面的过渡，其中第二横截面相对于第一横截面减小。 气体通过气体注入器在过渡区域中被注入导管，以产生从腔室去除不需要的材料的低压区域。

公开(公告)号：US08513598B2

公开(公告)日：2013-08-20

申请号：US12338623

申请日：2008-12-18

申请人： David P. Fergenson ,  Eric E. Gard

发明人： David P. Fergenson ,  Eric E. Gard

IPC分类号： H01J49/40

CPC分类号： H01J49/40 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/164

摘要： A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing light. Additional systems and methods are also disclosed.

摘要翻译： 根据一个实施方案的系统包括颗粒促进剂，其引导一系列多分散气溶胶颗粒沿着预定的颗粒路径; 用于在颗粒路径上产生光束的多个跟踪激光器; 位于颗粒路径附近的光学检测器，用于检测单个颗粒上的光束的撞击; 解吸激光器，用于产生与所述跟踪激光器之一产生的光束同轴的所述粒子路径上的解吸光束; 以及控制器，响应于检测由光学检测器产生的信号，其控制解吸激光器以产生解吸光束。 还公开了附加的系统和方法。

公开(公告)号：US07405398B2

公开(公告)日：2008-07-29

申请号：US11406462

申请日：2006-04-18

申请人： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

发明人： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC分类号： H01J49/00

CPC分类号： H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

摘要翻译： 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US20080104064A1

公开(公告)日：2008-05-01

申请号：US11548218

申请日：2006-10-10

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： G06F17/30

CPC分类号： H01J49/165 ,  H01J49/044

摘要： The invention provides a mass spectrometry interface for collecting ions and directing a drying gas. The mass spectrometer interface may be used independently or in combination with an ion source and a mass spectrometry system. The mass spectrometer interface, includes a body portion having a first open end; and a tip portion in contact with the body portion having a second open end and a wall with an aperture for receiving ion, the wall having a cross-sectional area that tapers from the first open end of the body portion toward the second open end of the tip portion, wherein the mass spectrometer interface may direct a gas from the first open end of the body portion toward the second open end of the tip portion and the aperture in the wall of the tip portion may receive ions for drying by the gas.The invention also provides methods for ion collection and drying. The method for collecting and drying molecules, includes directing ions through an aperture of a closed mass spectrometry interface; and drying the molecules using a drying gas.

摘要翻译： 本发明提供了用于收集离子和引导干燥气体的质谱界面。 质谱仪界面可以独立使用或与离子源和质谱系统组合使用。 质谱界面包括具有第一开口端的主体部分; 以及与所述主体部分接触的具有第二开口端的尖端部分和具有用于接收离子的孔的壁，所述壁具有从所述主体部分的第一开口端向第二开口端逐渐变细的横截面面积 尖端部分，其中质谱仪界面可以将气体从主体部分的第一开口端引导到尖端部分的第二开口端，并且尖端部分的壁中的孔可以接收由气体干燥的离子。 本发明还提供了用于离子收集和干燥的方法。 收集和干燥分子的方法包括将离子引导通过闭合质谱界面的孔; 并使用干燥气体干燥分子。

公开(公告)号：US20080067355A1

公开(公告)日：2008-03-20

申请号：US11441542

申请日：2006-05-25

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J49/04

CPC分类号： H01J49/044

摘要： A mass spectrometer sample input interface comprises a desolvation apparatus defining a desolvation pathway along which a desolvation gas flows, in a direction from upstream to downstream, the desolvation pathway having a desolvation pathway portion; and an ion pathway apparatus for defining an ion pathway for analyte solution droplets to follow, the ion pathway leading into the mass spectrometer, the ion pathway including an ion pathway portion that follows the desolvation pathway portion.

摘要翻译： 质谱仪样品输入界面包括去溶剂化装置，其定义了去溶剂化途径，去溶剂化气体沿着从上游到下游的方向从具有去溶剂化途径部分的去溶剂化途径流出; 以及离子通道装置，用于限定分析物溶液液滴的离子路径，通向质谱仪的离子通道，离子通路包括遵循去溶剂化途径部分的离子通路部分。