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    Compositions and methods for diagnosing and treating degenerative mitral valve disease in a canine
    1.
    发明授权
    Compositions and methods for diagnosing and treating degenerative mitral valve disease in a canine 有权

    公开(公告)号：US11624094B2

    公开(公告)日：2023-04-11

    申请号：US16716842

    申请日：2019-12-17

    申请人： Societe des Produits Nestle SA

    发明人： Qinghong Li

    IPC分类号： C12Q1/689 ,  A23K50/40 ,  A23K10/16 ,  A61K35/742

    摘要： The present invention relates to methods and compositions for diagnosing and treating degenerative mitral valve disease in a canine. In one embodiment, a method of diagnosing early stage degenerative mitral valve disease in a canine can comprise measuring a normalized relative abundance of a biomarker selected from the group consisting of Erysipelatoclostridium, Ruminococcaceae UCG014, Butyricicoccus, Faecalibacterium, and combinations thereof, and determining that the canine has early stage degenerative mitral valve disease if the Erysipelatoclostridium is from 0 to 0.5 normalized relative abundance, the Ruminococcaceae UCG014 is from 0 to 0.1 normalized relative abundance, the Butyricicoccus is from 0 to 0.1 normalized relative abundance, or the Faecalibacterium is from 0 to 0.1 normalized relative abundance.

    Use of Schizochytrium limacinum and its preparation in improving the quality and yield of animal product
    2.
    发明授权
    Use of Schizochytrium limacinum and its preparation in improving the quality and yield of animal product 有权

    公开(公告)号：US11583566B2

    公开(公告)日：2023-02-21

    申请号：US17043468

    申请日：2018-11-14

    申请人： XIAMEN HUISON BIOTECH CO., LTD

    发明人： Liyi Chen ,  Huichang Zhong ,  Shuirong Chen

    IPC分类号： A61K36/02 ,  A23K50/10 ,  A23K50/75 ,  A23K10/16 ,  C12N1/12 ,  A61K9/00 ,  C12R1/89

    摘要： The invention discloses the use of the Schizochytrium limacinum and its preparation in improving the quality and yield of animal product. The deposit number of Schizochytrium limacinum in the present invention is CGMCC No. 13746 in the China General Microbiological Culture Collection Center. The Schizochytrium limacinum powder produced by the Schizochytrium limacinum may increase the DHA content in an animal product, reduce the cholesterol content in an animal product, and also improve the egg production performance of poultry. This animal product with high DHA content from natural sources is organic, safe, stable, and easy to be absorbed. It may be used as a safer and effective way for people to ingest natural DHA, and it may also cater to and meet consumer needs. Thus, Schizochytrium limacinum and Schizochytrium limacinum powder of the present application have a wide range of application in the field of general food and livestock breeding.

    LACTOBACILLUS FERMENTUM STRAIN, AND COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASES CONTAINING SAME
    3.
    发明申请
    LACTOBACILLUS FERMENTUM STRAIN, AND COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASES CONTAINING SAME 有权

    公开(公告)号：US20230012950A1

    公开(公告)日：2023-01-19

    申请号：US17758210

    申请日：2020-12-29

    申请人： GI BIOME

    发明人： Bo Gie YANG ,  Myung Ho JANG ,  Chang Ho KANG ,  Nam Soo PAEK

    IPC分类号： C12N1/20 ,  A61K35/747 ,  A23L33/135 ,  A23K10/16 ,  A61P3/04

    摘要： There is provided a novel Lactobacillus fermentum strain (Accession No. KCTC 14105BP) and a composition for preventing or treating a metabolic disease including the same. A Lactobacillus fermentum according to the present invention may inhibit fat accumulation in white adipose tissue and increase anti-inflammatory cells. The Lactobacillus fermentum strain may exhibit excellent blood glucose improvement effect, and in particular, may reduce a fasting blood glucose level. The Lactobacillus fermentum strain may effectively ameliorate insulin resistance by improving glucose tolerance and increasing insulin sensitivity. In addition, the Lactobacillus fermentum strain may regulate a concentration of metabolic hormones and adipokines in blood. Therefore, the Lactobacillus fermentum strain may be usefully used to prevent and treat a metabolic disease such as obesity.

    Microbial biomass based feed products
    6.
    发明授权
    Microbial biomass based feed products 有权

    公开(公告)号：US11439172B2

    公开(公告)日：2022-09-13

    申请号：US15641114

    申请日：2017-07-03

    申请人： OAKBIO, INC.

    发明人： Brian A Sefton ,  William J Coleman

    IPC分类号： A23L33/135 ,  C12N1/20 ,  C12M1/00 ,  A23K20/10 ,  A23K50/80 ,  A23K10/16 ,  A23J1/00

    摘要： Aquafeed, animal feed, and other food products, as well as nutritional and pharmaceutical compounds, chemicals and biomaterials are important commodities that can be produced at commercial scale by fermentation of microorganisms. The present invention provides a method for producing these valuable multi-carbon compounds from simple gas feedstocks, such as carbon dioxide, hydrogen and oxygen, by cultivating a consortium of microbial cells specially selected for this purpose in an aqueous culture medium. In addition to exploiting inexpensive feedstocks, such as waste industrial gas for this cultivation, the platform described herein also provides the advantage of removing carbon dioxide and other waste gases from industrial emissions, which would otherwise contribute to global climate change. Furthermore, the cultivation of a microbial consortium can provide highly nutritious components to a feed blend that might not be available from a monoculture.

    ALGORIPHAGUS SP, BOSEA SP, BREVUNDIMONAS SP, DESULFOVIBRIO SP, MICROBACTERIUM SP, SPHINGOMONAS SP, AND VARIOVORAX SP FOR USE IN DISEASE PREVENTION AND TREATMENT
    7.
    发明申请
    ALGORIPHAGUS SP, BOSEA SP, BREVUNDIMONAS SP, DESULFOVIBRIO SP, MICROBACTERIUM SP, SPHINGOMONAS SP, AND VARIOVORAX SP FOR USE IN DISEASE PREVENTION AND TREATMENT 有权

    公开(公告)号：US20220226394A1

    公开(公告)日：2022-07-21

    申请号：US17576339

    申请日：2022-01-14

    申请人： ZIVO Bioscience, Inc.

    发明人： Amy E. Steffek ,  William P. Pfund ,  Andrew A. Dahl

    IPC分类号： A61K35/74 ,  A61P33/02 ,  A23K10/16 ,  A23K10/30

    摘要： A treatment compound and its use in the prevention and treatment diseases are disclosed. The compound comprises one or more materials selected from an algal biomass/supernatant (including both algae and bacteria), a bacterial biomass, and isolated and purified compound(s) as well as specific active sites or structures on those compounds. The treatment compound and the use of such a compound such as that derived from a bacterium that appears to selectively alter one or more TLR pathways in the prevention and treatment of disease in both animals and humans. The bacteria are selected from the group consisting of Algoriphagus sp., Bosea sp., Brevundimonas sp., Desulfovibrio sp., Microbacterium sp., Sphingomonas sp., and Variovorax sp. The disclosed inventive compound and method of treatment find particular application in the treatment of disease in poultry, particularly in the prevention and treatment of coccidiosis.