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134 条记录 (耗时 0.026 秒)

    BISMUTH-THIOL COMPOSITIONS AND METHODS FOR TREATING WOUNDS
    2.
    发明申请
    BISMUTH-THIOL COMPOSITIONS AND METHODS FOR TREATING WOUNDS 有权

    公开(公告)号：US20220233491A1

    公开(公告)日：2022-07-28

    申请号：US17713893

    申请日：2022-04-05

    申请人： Microbion Corporation

    发明人： Brett Hugh James BAKER

    IPC分类号： A61K31/29 ,  A61P17/02 ,  A61K9/14

    摘要： The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.

    Synthesis of high molecular weight iron-saccharidic complexes
    7.
    发明授权
    Synthesis of high molecular weight iron-saccharidic complexes 失效
    高分子量铁 - 糖配合物的合成

    公开(公告)号：US08691776B2

    公开(公告)日：2014-04-08

    申请号：US13108392

    申请日：2011-05-16

    申请人： Robert A. Beck ,  Robert A. Mateer, Jr. ,  John Kowalski

    发明人： Robert A. Beck ,  Robert A. Mateer, Jr. ,  John Kowalski

    IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/715 ,  A01N31/00 ,  A61K31/45 ,  A01N55/02 ,  A61K31/29 ,  A01N59/16 ,  A61K33/26 ,  C07C59/10 ,  C07C59/285

    CPC分类号： A61K31/715 ,  A61K31/191 ,  A61K31/295 ,  A61K31/7004 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/7024 ,  A61K33/26 ,  A61K45/06 ,  A61K47/61 ,  C08B37/0006 ,  C08B37/0009 ,  C08B37/0024

    摘要： A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH)− ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i):(ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e.g., lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.

    摘要翻译： 一种制备肠胃外铁 - 糖复合物的方法和所制备的复合物，包括：（1）提供包含（i）Fe（III）和（OH） - 离子的水溶液或分散体和（ii）至少一种糖， 形成反应混合物，其中（i）：（ii）的摩尔比为约30:1至约1:30; 混合物的温度和pH在复合装配点（CAP）以上; 和（2）将温度和pH保持在等于或高于CAP的时间足以形成分子量为约25,000道尔顿或更高的铁 - 糖配合物。 控制温度和pH有效地产生高分子量复合物。 可以通过沉淀，透析和/或柱分级分离复合物，并且如果需要，干燥，例如冻干或喷雾干燥。 该方法可以可控地合成不同分子量和/或化学组成的复合物，特别是葡萄糖酸铁钠和氢氧化铁 - 蔗糖。

    NOVEL BISMUTH(III) NSAID COMPOUNDS AND METHODS FOR THEIR USE
    8.
    发明申请
    NOVEL BISMUTH(III) NSAID COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
    新型双酚A（III）抗生素化合物及其使用方法

    公开(公告)号：US20110086911A1

    公开(公告)日：2011-04-14

    申请号：US12578118

    申请日：2009-10-13

    申请人： Philip Craig ANDREWS ,  Peter Courtney JUNK ,  Ish KUMAR ,  Richard L. FERRERO

    发明人： Philip Craig ANDREWS ,  Peter Courtney JUNK ,  Ish KUMAR ,  Richard L. FERRERO

    IPC分类号： A61K31/29 ,  C07F9/94 ,  A61P31/04

    CPC分类号： C07F9/94 ,  A61K31/29 ,  C07C57/30 ,  C07C59/56 ,  C07C59/64 ,  C07C59/84 ,  Y02A50/473

    摘要： The present invention relates to the field of non-specific anti inflammatory drugs (NSAIDs). In particular, the invention relates to bismuth(III) tris-carboxylate complexes having the formula [Bi(III)L3]n including its pharmaceutically acceptable salts and solvates, wherein, L is chosen from the group comprising carboxylato-NSAIDs, their derivatives, prodrugs or metabolytes, and n is ≧1.The bismuth(III) tris-carboxylate complexes of the invention may be formulated for use in treatments for a wide range of ailments, particularly those where an anti-microbial activity is advantageous. In a particularly preferred embodiment the bismuth(III) tris-carboxylate complexes of the present invention exhibit activity against bacteria found in the gastrointestinal tract such as Helicobacter pylori, Escherichia coli, Klebsiella pneumoniae, Bacillus pumilus, Staphylococcus aureus and Staphylococcus epidermidis.

    摘要翻译： 本发明涉及非特异性抗炎药（NSAID）的领域。 特别地，本发明涉及具有式[Bi（III）L3] n的铋（III）三羧酸复合物，其包括其药学上可接受的盐和溶剂化物，其中L选自羧酸 - 非甾体抗炎药，其衍生物， 前药或代谢组分，n为≥1。 本发明的三（III）三羧酸复合物可配制用于各种疾病的治疗，特别是抗微生物活性有利的那些。 在特别优选的实施方案中，本发明的铋（III）三羧酸盐复合物对胃肠道中发现的细菌具有活性，如幽门螺杆菌，大肠杆菌，肺炎克雷伯杆菌，短小芽孢杆菌，金黄色葡萄球菌和表皮葡萄球菌。

    Use of bismuth subgallate and borneol in treating melanoma
    10.
    发明申请
    Use of bismuth subgallate and borneol in treating melanoma 审中-公开
    使用铋酸钠和冰片治疗黑色素瘤

    公开(公告)号：US20070225364A1

    公开(公告)日：2007-09-27

    申请号：US11385876

    申请日：2006-03-21

    申请人： James Chen ,  Black Chen

    发明人： James Chen ,  Black Chen

    IPC分类号： A61K31/29 ,  A61K31/045

    CPC分类号： A61K31/045 ,  A61K31/29 ,  A61K33/245 ,  A61K2300/00

    摘要： A new use of bismuth subgallate and borneol for treating melanoma by the reduction of the number of melanoma cells and/or the inhibition of the proliferation of melanoma cells is provided. A use of bismuth subgallate and borneol for inhibiting the migration of melanoma cells is also provided.

    摘要翻译： 提供了通过减少黑素瘤细胞数量和/或抑制黑素瘤细胞增殖来治疗黑素瘤的新型铋铋和冰片的新用途。 还提供了使用铋铋和冰片抑制黑素瘤细胞的迁移。