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    BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHOGS OF MAKING
    5.
    发明申请
    BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHOGS OF MAKING 有权

    公开(公告)号：US20230090172A1

    公开(公告)日：2023-03-23

    申请号：US18053482

    申请日：2022-11-08

    申请人： VIRTECH BIO, INC.

    发明人： William Richard Light ,  Joseph Tucker

    IPC分类号： A61K38/42 ,  A61P7/08 ,  A61K9/00 ,  C12N5/078

    摘要： Methods for making hemoglobin based blood substitute preparations and hemoglobin based blood substitute preparations. The methods involve preparing a low purity erythrocyte protein fraction comprising hemoglobin protein and endogenous non-hemoglobin protein complement, and chemically modifying the proteins in the protein fraction to form a cross-linked hemoglobin containing blood substitute preparation. The low purity erythrocyte protein preparation can contain from at least about 0.2% (mole/mole) up to about 20% (mole/mole) endogenous non-hemoglobin protein complement. At least about 90% (mole/mole) of the hemoglobin proteins can be cross-linked, so that the average molecular mass of cross-linked proteins comprising hemoglobin protein molecules in the preparation is at least about 300 kDa. The preparations can be used to prepare finished blood substitute formulations for in-vivo and ex-vivo use.

    Pulse wave detection device, image analysis device, and biometric information generation system
    7.
    发明授权
    Pulse wave detection device, image analysis device, and biometric information generation system 有权

    公开(公告)号：US11064895B2

    公开(公告)日：2021-07-20

    申请号：US16346148

    申请日：2017-11-06

    申请人： Sharp Kabushiki Kaisha

    发明人： Junya Onishi ,  Yoshihisa Adachi ,  Tetsuya Okumura ,  Takashi Nunokawa ,  Rieko Ogawa

    IPC分类号： A61B5/021 ,  A61B5/024 ,  G06K9/00 ,  G06T7/00 ,  A61K38/42

    摘要： Pulse waves of a living body are detected with high accuracy. A pulse wave detection device includes a camera configured to capture an image of the living body a plurality of times through a first green filter and an infrared light filter having light transmission characteristics in a near-infrared light wavelength range within a wavelength range where a light absorption coefficient of oxidized hemoglobin is greater than a light absorption coefficient of reduced hemoglobin, and an image analysis unit configured to analyze a plurality of images of the living body captured by the camera and to detect the pulse waves of the living body. The image analysis unit is configured to detect the pulse waves by detecting a change in intensity of light in the near-infrared light wavelength range indicated by the plurality of images.

    Compositions and Methods for Treatment of Cancer
    8.
    发明申请
    Compositions and Methods for Treatment of Cancer 审中-公开

    公开(公告)号：US20200297658A1

    公开(公告)日：2020-09-24

    申请号：US16817268

    申请日：2020-03-12

    申请人： David S Terman

    发明人： David S Terman

    IPC分类号： A61K31/09 ,  A61K35/18 ,  A61K38/42 ,  A61K9/00

    摘要： Resistance of randomly dispersed and oxygen-starved lung tumor cells to chemo- and radiotherapy constitutes the vast majority recurrences and death from lung cancer. We use sickle cells derived from humans with sickle cell anemia to target oxygen-deprived tumor cells that persist and multiply after conventional treatment. Transfused sickle cells selectively occluded tumor microvessels and shut down blood flow to these oxygen-deprived pockets leading to tumor cell death and complete shrinkage of aggressive lung tumors. Combining the sickle cells with a vascular disrupting agents and radiation injure and narrow tumor blood vessels, amplified the scale of sickle cell-induced blood vessel closure and tumor cell killing. The strength of the tumor killing produced by this combination exceeded that of either agent alone or combined with conventional anti-angiogenics, chemotherapy or radiation. Combinatorial sickle cells-Combretastatin treatment thereby constitutes a major advance toward eradicating treatment-resistant tumor cells and reducing the frequency of lung cancer recurrence.