公开(公告)号：US20240261386A1

公开(公告)日：2024-08-08

申请号：US18165762

申请日：2023-02-07

申请人： KING FAISAL UNIVERSITY

发明人： JAWHAR GHARBI ,  MOHAMMED A. ALMALKI ,  AMEERA ALYAMI ,  MANEL BEN M'HADHEB

IPC分类号： A61K39/125 ,  A61K9/48 ,  A61P31/14 ,  C07K14/005

CPC分类号： A61K39/125 ,  A61K9/485 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/5254 ,  A61K2039/54 ,  C12N2770/32321 ,  C12N2770/32322 ,  C12N2770/32334 ,  C12N2770/32371

摘要： The Coxsackievirus B3 (CVB3) vaccine including a mutant strain of Coxsackievirus B3 (CVB3) (SEQ ID NO: 1) has specific double mutations introduced in the Internal Ribosome Entry Segment (IRES) region of the wild type Coxsackievirus B3 (CVB3) genome in the nucleotide positions 473 (in which uracil is substituted for cytosine) and 475 (in which cytosine is substituted for uracil). The resulting double mutant (SEQ ID NO: 1) demonstrates a significant decrease in its replicative capacity and a drastic decrease in its translation efficiency compared to the wild-type Coxsackievirus B3 (CVB3) strain.

公开(公告)号：US20240100145A1

公开(公告)日：2024-03-28

申请号：US18280362

申请日：2022-03-04

申请人： Moderna TX, Inc.

发明人： Brooke Bollman ,  Gaby Baldeon Vaca ,  Angelo Cucuzza ,  Yen-Ting Lai

IPC分类号： A61K39/125 ,  A61K9/51 ,  A61P31/16 ,  C07K14/005 ,  C12N7/00 ,  C12N9/50

CPC分类号： A61K39/125 ,  A61K9/5123 ,  A61P31/16 ,  C07K14/005 ,  C12N7/00 ,  C12N9/506 ,  A61K2039/5258 ,  C12Y304/22028

摘要： Aspects of the disclosure relate to compositions of messenger RNA vaccines and methods of administration thereof. Compositions provided herein include one or more RNA polynucleotides having an open reading frame encoding a picornavirus capsid polyprotein and a protease. Compositions provided herein include one or more RNA polynucleotides having an open reading frame encoding an active product that modulates the expression, structure or function of at least one other RNA or product thereof.

公开(公告)号：US20230330208A1

公开(公告)日：2023-10-19

申请号：US17719779

申请日：2022-04-13

申请人： Biological Mimetics, Inc.

发明人： Gregory J Tobin ,  Peter L Nara

IPC分类号： A61K39/125 ,  C07K14/005 ,  C07K16/10 ,  C07K14/095 ,  A61K39/12

CPC分类号： A61K39/125 ,  C07K14/005 ,  C07K16/1009 ,  C07K14/095 ,  A61K39/12 ,  A61K2039/58

摘要： Novel compositions useful as human rhinovirus immunogens are provided. The compositions enable a host response to sites normally not recognized by a host.

公开(公告)号：US20220280529A1

公开(公告)日：2022-09-08

申请号：US17192597

申请日：2021-03-04

申请人： Theralase Technologies, Inc.

发明人： Roger DUMOULIN-WHITE ,  Arkady MANDEL

IPC分类号： A61K31/555 ,  A61K39/125

摘要： A method for eliciting an immune response in a patient includes the sequential steps of: providing an immunogenic composition including an immunogen; adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen; and administering the immunogenic composition to the patient so as to elicit the immune response against the immunogen. A method for preparing an attenuated immunogenic composition includes the steps of: providing an immunogenic composition including an immunogen; and adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen in the immunogenic composition to provide the attenuated immunogenic composition.

公开(公告)号：US20220249650A1

公开(公告)日：2022-08-11

申请号：US17626337

申请日：2020-07-15

申请人： SOUTH DAKOTA BOARD OF REGENTS

发明人： Diego G. Diel ,  Marcelo de Lima ,  Maureen H.V. Fernandes ,  Bishwas Sharma

IPC分类号： A61K39/125 ,  C12N7/00 ,  C12N15/85 ,  A61K39/39 ,  A61P31/14

摘要： The present invention is directed to novel nucleotide sequences of Senecavirus A (“SVA”), including novel genotypes thereof, which are useful as live attenuated and other vaccine compositions for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine SVA genotypes and isolates. Diagnostic and therapeutic sequences are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length SVA genomes that can replicate efficiently in host animals and tissue culture.

公开(公告)号：US20220031832A1

公开(公告)日：2022-02-03

申请号：US17328135

申请日：2021-05-24

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Haixue Zheng ,  Fan Yang ,  Zixiang Zhu ,  Weijun Cao ,  Hong Tian ,  Keshan Zhang ,  Ting Wei ,  Min Zheng ,  Wei Zhang ,  Wen Dang ,  Xusheng Ma ,  Dan Li ,  Yi Ru ,  Jijun He ,  Jianhong Guo ,  Xiangtao Liu

IPC分类号： A61K39/125 ,  C12N15/10 ,  C12N15/66

摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.

公开(公告)号：US20210393554A1

公开(公告)日：2021-12-23

申请号：US17292714

申请日：2019-11-14

申请人： Bluewillow Biologics, Inc.

发明人： Susan Ciotti ,  David Peralta

IPC分类号： A61K31/14 ,  A61K9/107 ,  A61K38/13 ,  A61K39/39 ,  A61K31/43 ,  A61K31/545 ,  A61K38/14 ,  A61K38/12 ,  A61K31/4174 ,  A61K31/522 ,  A61K31/65 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/7048 ,  A61K39/21 ,  A61K39/215 ,  A61K39/12 ,  A61K39/125 ,  A61K39/145 ,  A61K39/00 ,  A61K39/35 ,  A61K39/02 ,  A01N33/12 ,  A01N25/04 ,  A01P1/00

摘要： The present disclosure relates to nanoemulsion compositions with certain surfactant blend ratios that impart enhanced permeability. Such compositions are useful for topical, mucosal, vaginal, and intranasal applications and allow for the greater delivery of one or more active agents to the application site.

公开(公告)号：US11160857B2

公开(公告)日：2021-11-02

申请号：US15737239

申请日：2016-06-15

申请人： Emory University ,  Children's Healthcare of Atlanta, Inc.

发明人： Martin L. Moore ,  Sujin Lee ,  Minh Trang Nguyen

IPC分类号： A61K39/125 ,  A61P31/16 ,  A61K39/12 ,  A61K39/00

摘要： This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent, mixtures of enterovirus (for example HRV) serotypes or recombinantly produced variants or recombinantly produced viral capsid proteins. In certain embodiments, the disclosure relates to methods of immunization comprising administering an effective amount of compositions disclosed herein to a subject diagnosed with, exhibiting symptoms of, or at risk of an enterovirus infection.

公开(公告)号：US11040097B2

公开(公告)日：2021-06-22

申请号：US16870020

申请日：2020-05-08

申请人： Takeda Vaccines, Inc.

发明人： Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William Tino

IPC分类号： A61K39/12 ,  A61K39/125 ,  A61K39/00 ,  C12N7/00 ,  A61K39/39

摘要： The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

公开(公告)号：US10434169B2

公开(公告)日：2019-10-08

申请号：US15892247

申请日：2018-02-08

申请人： SILLAJEN BIOTHERAPEUTICS, INC. ,  SILLAJEN, INC.

发明人： David Kirn ,  John Bell ,  Caroline Breitbach ,  Anne Moon ,  Tae-Ho Hwang ,  Yu Kyoung Lee ,  Mi-kyung Kim

IPC分类号： A61K39/285 ,  A61K39/00 ,  C07K16/30 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61K35/768 ,  A61K35/26 ,  A61K39/12 ,  A61K39/125 ,  A61K39/145 ,  A61K39/165 ,  A61K39/17 ,  A61K39/205 ,  A61K39/235 ,  A61K39/245 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C12N7/00 ,  G01N33/574

摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.