公开(公告)号：US11883411B2

公开(公告)日：2024-01-30

申请号：US17895390

申请日：2022-08-25

申请人： LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES

发明人： Keshan Zhang ,  Haixue Zheng ,  Huimei Cui ,  Bo Yang ,  Hong Tian ,  Zixiang Zhu ,  Tao Feng ,  Fan Yang ,  Weijun Cao ,  Xusheng Ma ,  Yi Ru ,  Jianhong Guo ,  Xiangtao Liu

IPC分类号： A61K31/5377 ,  A61P31/20

CPC分类号： A61K31/5377 ,  A61P31/20

摘要： The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.

公开(公告)号：US20220031832A1

公开(公告)日：2022-02-03

申请号：US17328135

申请日：2021-05-24

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Haixue Zheng ,  Fan Yang ,  Zixiang Zhu ,  Weijun Cao ,  Hong Tian ,  Keshan Zhang ,  Ting Wei ,  Min Zheng ,  Wei Zhang ,  Wen Dang ,  Xusheng Ma ,  Dan Li ,  Yi Ru ,  Jijun He ,  Jianhong Guo ,  Xiangtao Liu

IPC分类号： A61K39/125 ,  C12N15/10 ,  C12N15/66

摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.

公开(公告)号：US11883482B2

公开(公告)日：2024-01-30

申请号：US17328135

申请日：2021-05-24

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Haixue Zheng ,  Fan Yang ,  Zixiang Zhu ,  Weijun Cao ,  Hong Tian ,  Keshan Zhang ,  Ting Wei ,  Min Zheng ,  Wei Zhang ,  Wen Dang ,  Xusheng Ma ,  Dan Li ,  Yi Ru ,  Jijun He ,  Jianhong Guo ,  Xiangtao Liu

IPC分类号： C12N7/00 ,  C12N15/66 ,  C12N15/10 ,  A61K39/125 ,  A61K39/00

CPC分类号： A61K39/125 ,  C12N15/102 ,  C12N15/66 ,  A61K2039/5252 ,  A61K2039/53 ,  C12N7/00 ,  C12N2770/32034

摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.