公开(公告)号：US20230038788A1

公开(公告)日：2023-02-09

申请号：US17839754

申请日：2022-06-14

申请人： INSTITUT PASTEUR

发明人： JACQUES THEZE ,  THIERRY ROSE ,  FLORENCE BUGAULT

IPC分类号： C07K16/40 ,  A61K39/38

摘要： Methods for diagnosing or treating immune disorders in a subject are provided. The methods are based on the detection or modulation of Refractory state Inducing Factor (RIF).

公开(公告)号：US11524067B2

公开(公告)日：2022-12-13

申请号：US14282702

申请日：2014-05-20

申请人： Zoetis Services LLC

发明人： Cassius McAllister Tucker ,  John David Haworth

IPC分类号： A61K39/175 ,  A61K39/295 ,  A61K39/00 ,  A61K39/38 ,  A61K39/235 ,  A61K39/02 ,  A61K39/12 ,  A61K39/155 ,  A61K39/23 ,  C07K14/005 ,  C12N7/00

摘要： This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral antigens, a bacterin, or both, and wherein the vaccine is administered subcutaneously or orally according to the schedules provided herein.

公开(公告)号：US11485973B2

公开(公告)日：2022-11-01

申请号：US17029860

申请日：2020-09-23

申请人： SNIPR Biome ApS

发明人： Morten Sommer ,  Virginia Martinez ,  Eric Van der Helm ,  Jakob Krause Haaber ,  Ana De Santiago Torio ,  Christian Grøndahl ,  Jasper Clube

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/09 ,  A61K39/085 ,  A61K39/10 ,  A61K39/08 ,  A61K39/102 ,  A61K39/118 ,  C12N15/11 ,  A61P31/04 ,  A61K39/395 ,  A61K38/46 ,  C07K16/28

摘要： The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.

公开(公告)号：US11213553B2

公开(公告)日：2022-01-04

申请号：US15901962

申请日：2018-02-22

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali ,  Shaheen Majeed

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali ,  Shaheen Majeed

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/07 ,  A01N63/00 ,  A61K35/742 ,  A61P1/14 ,  A61K9/00 ,  A61K9/48 ,  A61K9/20 ,  A23L33/135 ,  A61K35/00

摘要： Disclosed is the hypolipidemic potential of Bacillus coagulans. More specifically the invention discloses the cholesterol lowering potential of Bacillus coagulans MTCC 5856 and therapeutic/biological indications thereof.

公开(公告)号：US11207376B2

公开(公告)日：2021-12-28

申请号：US16603507

申请日：2018-04-06

申请人： Second Genome, Inc.

发明人： Andrew Wonhee Han ,  Andrew Whitman Goodyear ,  Tarunmeet Gujral ,  Todd Zachary Desantis ,  Karim Dabbagh ,  Toshihiko Takeuchi ,  Ye Jin ,  Michi Izumi Willcoxon ,  Stefanie Banas

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/08 ,  A61K39/02 ,  A61P1/04 ,  C07K2/00 ,  A61K38/16 ,  A61P37/02 ,  C07K14/33 ,  C07K14/195 ,  A61K38/00

摘要： The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

公开(公告)号：US10918706B2

公开(公告)日：2021-02-16

申请号：US16696190

申请日：2019-11-26

申请人： Cornell University

发明人： David A. Putnam ,  Joseph Rosenthal ,  Chung-Jr Huang ,  Matthew DeLisa ,  Susana Mendez

IPC分类号： A01N63/00 ,  A61K39/015 ,  A61K39/12 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K39/39 ,  A61K38/16 ,  A61K39/38 ,  C12N15/70 ,  A61K39/00

摘要： The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.

公开(公告)号：US10758605B2

公开(公告)日：2020-09-01

申请号：US15740622

申请日：2016-06-29

申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

发明人： Nobuyuki Matoba ,  Keegan Baldauf ,  Joshua Royal

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/106 ,  A61K39/02 ,  C07K14/28 ,  A61K39/39

摘要： Protein complex variants, compositions, and methods of use thereof are provided. The protein complex variant includes a cholera toxin B subunit variant having one or more modifications thereto. The method of use thereof includes treating a disease by administering an effective amount of a composition including a cholera toxin B subunit variant to a subject in need thereof.

公开(公告)号：US10702564B2

公开(公告)日：2020-07-07

申请号：US15523710

申请日：2015-11-03

申请人： FUGENBIOPHARMA CO., LTD.

发明人： Yoon Soo Kim

IPC分类号： A01N65/00 ,  A61K36/06 ,  A61K36/09 ,  A01N63/04 ,  A61K39/00 ,  A61K39/38 ,  A61K36/07 ,  A23L33/10

摘要： The present invention relates to a blood pressure lowering composition which contains as an active ingredient exopolysaccharide produced by means of Ceriporia lacerata, a Ceriporia lacerata mycelium culture medium comprising same, or dry powder or an extract of same. The composition can be used as an antihypertensive for preventing or treating hypertension or cerebral apoplexy or as a functional health food having antihypertensive effect.

公开(公告)号：US10669316B2

公开(公告)日：2020-06-02

申请号：US16226909

申请日：2018-12-20

申请人： Genome Protection, Inc.

发明人： Vadim Mett

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/38 ,  C07K14/195 ,  A61K38/16 ,  A61K39/39 ,  A61K45/06

摘要： The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.

公开(公告)号：US10596255B2

公开(公告)日：2020-03-24

申请号：US16389376

申请日：2019-04-19

申请人： SNIPR Technologies Limited

发明人： Jasper Clube

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/09 ,  A61K39/085 ,  A61K39/10 ,  A61K39/08 ,  A61K39/102 ,  A61K39/118 ,  A61K39/395 ,  A61K35/15 ,  A61K35/17 ,  A61K31/7105 ,  A61P37/00 ,  A61P35/00

摘要： The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.