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公开(公告)号：US20210276959A1
公开(公告)日：2021-09-09
申请号：US17323337
申请日：2021-05-18
申请人： BASF SE
IPC分类号： C07D237/20 , C07D401/12 , C07B31/00 , C07B39/00 , C07B43/04 , C07D237/12 , C07D403/12
摘要： Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.
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公开(公告)号：US10899760B2
公开(公告)日：2021-01-26
申请号：US16745418
申请日：2020-01-17
发明人： Jiang Zhu , Mohammad Masjedizadeh
IPC分类号： C07D471/04 , A61P35/00 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04
摘要： Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
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3.发明授权公开(公告)号：US10851060B2
公开(公告)日：2020-12-01
申请号：US16221600
申请日：2018-12-17
发明人： Huiyue Li , Keqiang Jin , Jiaquan Zhu
IPC分类号： C07D213/04 , C07D213/61 , B01D3/14 , B01J19/12 , C07B39/00
摘要： The present invention relates to a method for preparing 2,6-dichloropyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between pyridine and chlorine gas. The preparation process comprises the following steps: enabling pyridine and chlorine gas to continuously experience chlorination reaction under irradiation of ultraviolet light by using pyridine and chlorine gas as starting materials and using trifluoromethyl chlorobenzene as a solvent, and cooling a chlorination reaction product and the solvent to obtain pyridine chlorination solution. Advantages: firstly, it pioneers the precedent of direct and high-selectivity preparation of 2,6-dichloropyridine through liquid phase photochlorination, and not only can the 2,6-dichloropyridine product with purity greater than or equal to 99.0% be obtained, but also industrial production is facilitated; and secondly, not only can the reuse of the separated solvent in the preparation process of the 2,6-dichloropyridine product with purity greater than or equal to 99.0% be realized, but also the purposes of low pollution, low energy consumption and low cost in the preparation process can be realized.
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公开(公告)号：US10702858B2
公开(公告)日：2020-07-07
申请号：US16214793
申请日：2018-12-10
发明人： Bo Xu , Zhichao Lu , Gerald B. Hammond
IPC分类号： B01J27/055 , C07D277/56 , C07C67/287 , C07C303/30 , C07D209/50 , C07C303/34 , C07C201/12 , C07C213/08 , C07C253/30 , C07C45/63 , C07D215/227 , C07D307/68 , C07D333/38 , C07D207/34 , C01D5/00 , C07C17/087 , C07C67/307 , C07C51/363 , C07B39/00 , C07C29/62 , B01J31/00
摘要： Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
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公开(公告)号：US10689314B2
公开(公告)日：2020-06-23
申请号：US15568017
申请日：2016-04-18
IPC分类号： C07C15/14 , C07C41/01 , C07F5/02 , C07C41/30 , C07F7/00 , C07B39/00 , C07B51/00 , C07C15/20 , C07C43/23
摘要： New methods for preparing bridged bi-aromatic ligands are disclosed. The methods employ aryl coupling of unprotected phenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.
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公开(公告)号：US10584102B2
公开(公告)日：2020-03-10
申请号：US15572303
申请日：2016-05-10
申请人： BASF SE
IPC分类号： C07D403/12 , C07D237/12 , C07D237/20 , C07B31/00 , C07B39/00 , C07B43/04
摘要： Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.
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公开(公告)号：US10577326B1
公开(公告)日：2020-03-03
申请号：US16221603
申请日：2018-12-17
发明人： Huiyue Li , Keqiang Jin , Jiaquan Zhu
IPC分类号： C07D213/61 , C07B39/00 , B01D3/14 , B01J19/12
摘要： The present invention relates to a method for preparing 2-chloro-6-trichloromethylpyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between 2-methylpyridine with chlorine gas, in which 2-methylpyridine and chlorine gas are used as starting materials, trifluoromethyl chlorobenzene is used as a solvent, 2-methylpyridine is prepared into a liquid raw material by using the solvent trifluoromethyl chlorobenzene, and the liquid raw material is continuously fed to perform liquid phase photochlorination reaction at temperature of 160-240° C. under irradiation of ultraviolet light to obtain 2-chloro-6-trichloromethylpyridine solution. Advantages: the selectivity of reaction for the production of 2-chloro-6-trichloromethylpyridine is improved, the content of components such as isomers and pentachloromethylpyridine in the crude product is decreased significantly, the crude product is easy to be purified to obtain the 2-chloro-6-trichloromethylpyridine product with purity greater than or equal to 99.0%, and the industrial production is facilitated; and secondly, not only can the reuse of the separated solvent in the preparation process of the 2,6-dichloropyridine product with purity greater than or equal to 99.0% be realized, but also the purposes of low pollution, low energy consumption and low cost in the preparation process are realized.
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公开(公告)号：US10538518B2
公开(公告)日：2020-01-21
申请号：US15748212
申请日：2016-08-10
发明人： Jiang Zhu , Mohammad Masjedizadeh
IPC分类号： C07D471/04 , A61P35/00 , C07B35/02 , C07B35/06 , C07B39/00 , C07B43/04 , C07B43/06 , C07B45/04
摘要： To an appropriate reactor equipped with mechanical stirrer was charged acetic acid (12 L), tert-butyl 4-(3-(6-(3,5-dimethoxyphenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)propyl)piperazine-1-carboxylate (2000 g) and triethylamine (639 g, 2.3 eq.). Internal temperature was adjusted to approximately 20° C. and N-chlorosuccinimide (1651 g, 4.5 eq.) was added at 20-30° C. Reaction was stirred for 2 hours. Ethyl acetate (30 L) was added. 5% aqueous NaCl solution (20 L) was added. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with 30% aqueous potassium carbonate solution (14 L). The organic layer was concentrated to ˜12 L and used for next step directly.
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公开(公告)号：US10519172B2
公开(公告)日：2019-12-31
申请号：US16308304
申请日：2017-06-23
发明人： Nathaniel Szymczak , Jacob Geri
IPC分类号： C07F5/05 , C07B39/00 , C07B37/02 , C07B47/00 , C07C17/278 , C07C29/64 , C07C209/52
摘要： Disclosed herein are borazine complexes and use of the same in perfluoroalkylation reactions.
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公开(公告)号：US09676795B2
公开(公告)日：2017-06-13
申请号：US14000116
申请日：2012-02-17
IPC分类号： C07F1/08 , C07B39/00 , C07C17/32 , C07C201/12 , C07F1/00 , C07C41/30 , C07C45/45 , C07C45/68
CPC分类号： C07F1/08 , C07B39/00 , C07C17/32 , C07C41/30 , C07C45/455 , C07C45/68 , C07C201/12 , C07F1/005 , C07C22/08 , C07C205/11 , C07C43/225 , C07C49/80
摘要： Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (I) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform.
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