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    Synthesis of 11-aryl-5,6,-dihydro-11H-dibenz [b,e] azepines
    3.
    发明申请
    Synthesis of 11-aryl-5,6,-dihydro-11H-dibenz [b,e] azepines 审中-公开
    合成11-芳基-5,6'-二氢-11H-二苯并[b，e]吖庚因

    公开(公告)号：US20010007030A1

    公开(公告)日：2001-07-05

    申请号：US09777528

    申请日：2001-02-06

    申请人： Pharm-Eco Laboratories

    发明人： Adel M. Moussa ,  Richard J. Lombardy ,  Reem M. Haider ,  Minghua Sun

    IPC分类号： C07C221/00 ,  C07C223/00 ,  C07C225/00

    CPC分类号： C07C215/68 ,  C07C225/22 ,  C07D223/20

    摘要： Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenznullb,enullazepines from a 2-aminobenzophenone represented by the following structural formula: 1 and a starting material represented by the following structural formula: 2 ,2 Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen. R is nullH, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, nullC(O)nullRnull, nullC(O)nullH, nullC(O)nullNHRnull, nullS(O)2Rnull, nullC(O)nullC(O)nullRnull, nullC(O)nullC(O)nullH, nullC(S)nullRnull, nullC(S)nullH, nullC(O)nullORnull, nullC(S)nullORnull, nullC(O)nullSRnull, nullC(S)nullSRnull, nullC(O)nullNRnull2 or nullC(O)nullC(S)nullRnull. Rnull is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R1 is a leaving group. The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenznullb,enullazepines.

    摘要翻译： 公开了由以下结构式表示的2-氨基二苯甲酮的11-芳基-5,6-二氢-11H-二苯并[b，e]吖庚因的三步合成：和由下列结构式表示的原料： 2苯基环A，苯环B和苯环C独立地是未取代的或被一个，两个或三个取代基取代。 苯环A，苯环B和苯环C上的每个取代基是独立选择的。 R为-H，脂族基团，取代脂族基团，芳基，取代芳基，-C（O）-R'， - （O）-H，-C（O）-NHR' S（O）2 R'， - C（O）-C（O）-R'， - C（O）-C（O）-H，-C（S）-R'， - ，-C（O）-OR'， - C（S）-OR'， - C（O）-SR'，-C（S）-SR'，-C（O）-NR'2或-C O）-C（S）-R'。 R'是脂族基团，取代的脂族基团，芳基或取代的芳基。 R1是离开组。 本发明还包括作为制备11-芳基-5,6-二氢-11H-二苯并[b，e]吖庚因的中间体的新化合物。

    Preparation of alpha-hydroxyketones
    7.
    发明授权
    Preparation of alpha-hydroxyketones 有权
    α-羟基酮的制备

    公开(公告)号：US08575394B2

    公开(公告)日：2013-11-05

    申请号：US13557281

    申请日：2012-07-25

    申请人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    发明人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    IPC分类号： C07C225/00 ,  C07C223/00

    CPC分类号： C07F7/1892 ,  C07C45/30 ,  C07C45/58 ,  C07C49/82 ,  C07C49/83 ,  C07C49/747 ,  C07C49/84

    摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alia as photoinitiators.

    摘要翻译： 公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在 在碱和极性溶剂的存在下，与酮反应。 所得类型的环氧乙烷可以通过在过渡金属催化剂存在下进行有氧氧化，或者在两步骤中在水溶液存在下进行水解，可以在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮 酸至相应的二醇并随后进行选择性氧化。 进一步描述了一些新型的环氧化物中间体。 因此可获得的α-羟基酮和α-氨基酮特别可用作光引发剂。

    Synthesis of soluble functionalized lithium initiators
    10.
    发明授权
    Synthesis of soluble functionalized lithium initiators 失效
    可溶性官能化锂引发剂的合成

    公开(公告)号：US07671237B2

    公开(公告)日：2010-03-02

    申请号：US11479717

    申请日：2006-06-30

    申请人： Adel Farhan Halasa ,  Wen-Liang Hsu

    发明人： Adel Farhan Halasa ,  Wen-Liang Hsu

    IPC分类号： C07C221/00 ,  C07C225/00 ,  C08C19/22

    CPC分类号： B60C1/0016 ,  C07F1/005 ,  C07F1/02 ,  C08C19/44 ,  C08F36/04 ,  C08F4/488

    摘要： This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents. The present invention also discloses a tire which is comprised of a generally toroidal-shaped carcass with an outer circumferential tread, two spaced beads, at least one ply extending from bead to bead and sidewalls extending radially from and connecting said tread to said beads, wherein said tread is adapted to be ground-contacting, and wherein said tread is a cured the rubber formulation which is comprised of (a) at least one rubbery polymer containing functional groups of the structural formula: wherein R, R′ and R″ can be the same or different, wherein R is selected from the group consisting of hydrogen atoms, alkyl groups, aryl groups, alkaryl groups, and amino aryl groups, and wherein R′ and R″ represent alkyl groups alkyl groups that contain from 1 to 8 carbon atoms, and (b) at least one member selected from the group consisting of carbon black and silica.

    摘要翻译： 本发明公开了一种制备高纯度二锂引发剂的方法。 该方法可以在不存在胺的情况下进行，因为胺可以用作阴离子聚合的改性剂。 所制备的二锂化合物是非常需要的，因为它们可溶于芳族溶剂。 本发明还公开了一种轮胎，其包括具有外圆周胎面的大致环形胎体，两个间隔开的胎圈，从胎圈到胎圈延伸的至少一个帘布层和从所述胎面径向延伸并将所述胎面连接到所述胎圈的侧壁，其中 所述胎面适于与地面接触，并且其中所述胎面是固化的橡胶配方，其由（a）至少一种含有以下结构式的官能团的橡胶状聚合物组成：其中R，R'和R“可以是 相同或不同，其中R选自氢原子，烷基，芳基，烷芳基和氨基芳基，其中R'和R“表示含有1至8个碳的烷基基团 原子，和（b）选自碳黑和二氧化硅中的至少一种。