公开(公告)号：US20240122910A1

公开(公告)日：2024-04-18

申请号：US18319287

申请日：2023-05-17

申请人： Akebia Therapeutics, Inc.

发明人： James Densmore Copp ,  Ann W. Newman ,  Anne Luong

IPC分类号： A61K31/444 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/4418 ,  C07D213/803 ,  C07D213/81

CPC分类号： A61K31/444 ,  A61K9/14 ,  A61K9/2054 ,  A61K9/48 ,  A61K9/4866 ,  A61K31/4418 ,  C07D213/803 ,  C07D213/81 ,  C07B2200/13 ,  C07D221/00

摘要： Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders.

公开(公告)号：US20230399302A1

公开(公告)日：2023-12-14

申请号：US18034439

申请日：2021-10-29

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

发明人： Justin M. Lopchuk ,  Zachary P. SHULTZ ,  Thomas SCATTOLIN

IPC分类号： C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

CPC分类号： C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

摘要： The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

公开(公告)号：US20210252174A1

公开(公告)日：2021-08-19

申请号：US17125531

申请日：2020-12-17

申请人： Norsk Medisinsk Syklotronsenter AS

发明人： Dag Erlend Olberg ,  Anders Svadberg

IPC分类号： A61K51/04 ,  C07D213/65 ,  C07D213/74 ,  C07D213/80 ,  C07D213/82 ,  C07D213/803 ,  C07B59/00 ,  C07D213/61 ,  A61K51/08 ,  C07D401/04

摘要： The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their use in such methods. PET imaging methods and methods of diagnosis employing such radiolabelling agents form a further aspect of the invention.

公开(公告)号：US20200339529A1

公开(公告)日：2020-10-29

申请号：US16765376

申请日：2018-11-19

申请人： Leibniz-lnstitut fur Naturstoff-Forschung und Infektionsbiologie E.V.Hans-Knoll-lnstitut (HKI)

发明人： Florian Kloss ,  Toni Neuwirth ,  Veit Haensch ,  Christian Hertweck

IPC分类号： C07D311/80 ,  C07C67/333 ,  C07D317/50 ,  C07C253/30 ,  C07D213/803 ,  C07C45/67 ,  C07C319/14 ,  C07C41/18 ,  C07D333/60

摘要： The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

公开(公告)号：US10800733B2

公开(公告)日：2020-10-13

申请号：US16346516

申请日：2018-03-15

申请人： Shanghai Bioenergy Medicine Science & Technology Co., Ltd.

发明人： Yuqiong Dong ,  Quanhai Liu ,  Yu Shen ,  Wentao Cai

IPC分类号： C07C235/24 ,  A61P3/06 ,  C07C231/02 ,  C07D213/807 ,  C07D213/82 ,  A61K31/455 ,  A61K31/16 ,  C07D213/803 ,  A61K31/167 ,  C07C235/16 ,  C07D213/80 ,  A61K31/44

摘要： Disclosed are a compound represented by Formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, the Formula I, and an application thereof in preparing drugs for regulating blood lipids.

公开(公告)号：US10179768B2

公开(公告)日：2019-01-15

申请号：US15022841

申请日：2014-09-16

申请人： ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE)

发明人： Stuart Aiken ,  Daniel Luke Crossley ,  Christopher David Gabbutt ,  Bernard Mark Heron ,  Claudine Biver ,  Samuel Archambeau ,  Fabien Berit-Debat

IPC分类号： C07D213/06 ,  C07D213/22 ,  C07D213/80 ,  C07D213/26 ,  C09K9/02 ,  C07D213/803 ,  G02C7/10 ,  G02F1/15

摘要： The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens and the use of these two-core viologens as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.

公开(公告)号：US20180311384A1

公开(公告)日：2018-11-01

申请号：US15771152

申请日：2016-10-26

申请人： Norsk Medisinsk Syklotronsenter AS

发明人： Dag Erlend Olberg ,  Anders Svadberg

IPC分类号： A61K51/04 ,  C07D213/803 ,  C07D213/80 ,  C07D213/65 ,  A61K51/08 ,  C07D401/04 ,  C07D213/82 ,  C07B59/00

CPC分类号： C07B59/008 ,  C07B59/002 ,  C07D213/61 ,  C07D213/74 ,  C07D213/80 ,  C07D213/803

摘要： The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their use in such methods. PET imaging methods and methods of diagnosis employing such radiolabelling agents form a further aspect of the invention.

公开(公告)号：US09902697B2

公开(公告)日：2018-02-27

申请号：US15317255

申请日：2014-06-27

申请人： AGRO-KANESHO CO., LTD.

发明人： Ryo Aizawa ,  Koichi Araki

IPC分类号： C07D213/803

CPC分类号： C07D213/803

摘要： The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III]with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I].

公开(公告)号：US20170349549A1

公开(公告)日：2017-12-07

申请号：US15683813

申请日：2017-08-23

申请人： Dow AgroSciences LLC

发明人： James M. Renga ,  Gregory T. Whiteker ,  Peter Lee Johnson ,  Christopher Galliford

IPC分类号： C07D213/803 ,  C07D213/73 ,  C07C251/12 ,  C07D213/72 ,  C07D213/79 ,  C07D213/74

CPC分类号： C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

摘要： 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

公开(公告)号：US09718783B2

公开(公告)日：2017-08-01

申请号：US15339190

申请日：2016-10-31

申请人： DOW AGROSCIENCES LLC

发明人： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy ,  Kenneth E. Stockman

IPC分类号： C07D213/79 ,  C07D213/84 ,  C07D213/803 ,  C07D307/54

CPC分类号： C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

摘要： 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.