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1.发明公开公开(公告)号：US20240099128A1
公开(公告)日：2024-03-21
申请号：US18269881
申请日：2022-01-11
发明人： Yuya OHKURA , Hideaki TAKAHASHI , Hiroshi SATO
IPC分类号： H10K85/60 , C07C225/22 , C07C229/44 , C07C255/42 , C07D209/86 , C07D239/66 , C07D265/38 , C07D279/28 , C07D333/22 , C07D409/14
CPC分类号： H10K85/633 , C07C225/22 , C07C229/44 , C07C255/42 , C07D209/86 , C07D239/66 , C07D265/38 , C07D279/28 , C07D333/22 , C07D409/14 , H10K85/636 , H10K30/86
摘要： An object of the present invention is to provide a compound that is useful as a hole transport material for providing a device for converting light into electricity that is capable of extracting current with high efficiency, and a device for converting light into electricity and a solar cell that include the compound in a hole transport layer and have favorable light/electricity conversion characteristics. The present invention provides a compound represented by the general formula (1) below. In the formula, R1 to R20 each represent a hydrogen atom, an alkoxy group having 1 to 20 carbon atoms, or the like, and Y represents an oxygen atom or CR21R22, where R21 and R22 each represent a nitrile group, an acyl group having 1 to 10 carbon atoms, or the like.
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公开(公告)号：US20230257410A1
公开(公告)日：2023-08-17
申请号：US18056008
申请日：2022-11-16
IPC分类号： C07H7/06 , C07D279/28 , C07D417/06
CPC分类号： C07H7/06 , C07D279/28 , C07D417/06
摘要： The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).
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公开(公告)号：US20210137938A1
公开(公告)日：2021-05-13
申请号：US17059297
申请日：2019-05-31
申请人： INSTITUT NATIONAL DE SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO (ARAID) , MIGUEL HERNANDEZ UNIVERSITY OF ELCHE , FUNDACION INSTITUTO DE INVESTIGACION SANITARIA ARAGON , CHONGQING UNIVERSITY , INSTITUT JEAN PAOLI & IRENE CALMETES , UNIVERSITÉ D'AIX-MARSEILLE , UNIVERSITY OF ZARAGOZA , INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD - ARAGON INSTITUTE OF HEALTH SCIENCES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CONSIGLIO NAZIONALE DELLE RICERCHE- NATIONAL RESEARCH COUNCIL ITALY
发明人： Olga ABIAN FRANCO , Patricia SANTOFIMIA , Yi XIA , Jose Luis NEIRA , Bruno RIZZUTI , Adrian VELAZQUEZ CAMPOY , Ling PENG , Juan IOVANNA
IPC分类号： A61K31/5415 , A61K45/06 , C07D279/28 , C07D417/12 , A61P35/00
摘要： The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived from different tumors, i.e. U87 (glioblastoma), A375 and B16 (melanoma), U20S and SaOS (osteosarcoma), HT29, SK-CO-1 and LS174T (colon cancer), HepG2 (hepatocarcinoma), PC3 (prostate) and MDA-MB-231 (breast cancer). The compounds per se are also claimed.
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公开(公告)号：US20210061837A1
公开(公告)日：2021-03-04
申请号：US16640482
申请日：2019-04-05
IPC分类号： C07H7/06 , C07D279/28 , C07D417/06
摘要： The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).
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公开(公告)号：US20190233384A1
公开(公告)日：2019-08-01
申请号：US16312627
申请日：2017-06-22
申请人： Bioimics AB
IPC分类号： C07D279/28 , C07D279/20 , C07D265/38 , C07D241/46 , C07D417/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D413/12 , C07D513/04 , C07D513/06 , A61P31/04 , A61P31/10 , A61P33/00
CPC分类号： C07D279/28 , A61P31/04 , A61P31/10 , A61P33/00 , C07D241/46 , C07D265/38 , C07D279/20 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/06
摘要： The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.
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公开(公告)号：US20190106394A1
公开(公告)日：2019-04-11
申请号：US16104840
申请日：2018-08-17
IPC分类号： C07D265/36 , C07D498/04 , A61K9/08 , A61K9/10 , C07D279/28 , C07D279/16 , C07D209/08 , A61K9/02 , C07D413/06 , A61K9/48 , A61K9/20
摘要： The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
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公开(公告)号：US10087151B2
公开(公告)日：2018-10-02
申请号：US15110082
申请日：2015-01-08
IPC分类号： C07D265/36 , C07D413/06 , C07D498/04 , C07D209/08 , C07D279/16 , C07D279/28 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48
摘要： The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
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公开(公告)号：US20180057471A1
公开(公告)日：2018-03-01
申请号：US15683679
申请日：2017-08-22
IPC分类号： C07D279/28 , H01M8/18 , H01M8/1018 , C08G65/00
CPC分类号： C07D279/28 , C08G65/002 , C08G65/3348 , C08G2650/62 , C08G2650/64 , H01M8/1018 , H01M8/186 , H01M8/188
摘要： Compounds for use as electrolyte in a non-aqueous redox battery are provided, including an N-substituted phenothiazine compound according to the formula: R′ is alkyl and R is selected from alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, arylcarbonyl, haloalkyl, perfluoroalkyl, glycol, polyether, haloaryl, a negative electrolyte, a polymerizable unit, and a polymer.
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9.发明授权Method for diagnosing or prediagnosing a beta-amyloidopathy or an alpha-synucleopathy 有权用于诊断或预诊断β-淀粉样变性或α-突触核蛋白病的方法公开(公告)号：US09370523B2
公开(公告)日：2016-06-21
申请号：US14499918
申请日：2014-09-29
申请人： Immungenetics AG
发明人： Jens Pahnke
IPC分类号： G01N33/68 , A61K31/5415 , C07D279/24 , C07D417/06 , C07D417/14 , A61K31/495 , C07D279/28 , G01N33/48
CPC分类号： A61K31/5415 , A61K31/495 , C07D279/24 , C07D279/28 , C07D417/06 , C07D417/14 , G01N33/48 , G01N33/6896 , G01N2333/705 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： The invention relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances transported by the cerebral ABCC1 transporter.
摘要翻译： 本发明涉及一种用于诊断或预诊和伴随脑蛋白沉积的α-突触核蛋白病和脑ABAC1转运蛋白活性降低的方法，或用于确定患有此类疾病的先证者的风险 一种疾病，先证者已经积累了由大脑ABCC1转运蛋白运输的物质。
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10.发明授权公开(公告)号：US07906643B2
公开(公告)日：2011-03-15
申请号：US12697503
申请日：2010-02-01
申请人： Thomas M DiMauro
发明人： Thomas M DiMauro
IPC分类号： C07D279/28 , A61K31/5415
CPC分类号： C07D279/28
摘要： A methylene blue-curcumin hybrid useful in treating Alzheimer's Disease.
摘要翻译： 用于治疗阿尔茨海默氏病的亚甲基蓝 - 姜黄素杂合物。
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