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    Process for the manufacture of epoxy-monomers and epoxides
    3.
    发明授权
    Process for the manufacture of epoxy-monomers and epoxides 有权
    制备环氧单体和环氧化物的方法

    公开(公告)号：US09573917B2

    公开(公告)日：2017-02-21

    申请号：US14897241

    申请日：2014-06-09

    申请人： SPOLEK PRO CHEMICKOU A HUTNI VYROBU A.S.

    发明人： Pavel Kubicek ,  Bedrich Nemecek ,  Petr Sladek

    IPC分类号： C07D301/24 ,  C07D301/26 ,  C07D301/32

    CPC分类号： C07D301/26 ,  C07D301/32 ,  C08G65/22 ,  C08G2650/32

    摘要： A process for manufacturing epoxy monomers and/or epoxides in high yields and useful quality and chemical stability by dehydrochlorination of the corresponding chlorohydrins with an alkaline agent, producing the corresponding side product dry salt in a high purity, characterized in that the process comprises the following steps: a. Reaction of the chlorohydrins with the alkaline agent to form corresponding epoxides and the corresponding precipitated chloride salt; b. Dehydration, and optionally completing the reaction, of the reaction mixture of step (a), by use of an azeotropic agent, added to step (b) or generated in situ in step (a), resulting in the producing of a dehydrated reaction mixture; c. Separating the resulting chloride salt by filtration from the dehydrated reaction mixture (b) and d. Isolating the epoxide from the filtered liquid fraction.

    摘要翻译： 一种以高产率制备环氧单体和/或环氧化物的方法，并且通过用碱性试剂对相应的氯代醇进行脱氯化氢来产生有用的质量和化学稳定性，产生高纯度的相应的副产物干盐，其特征在于该方法包括以下 步骤：a。 氯醇与碱性试剂的反应形成相应的环氧化物和相应的沉淀氯化物盐; b。 通过使用加入到步骤（b）中的共沸剂或在步骤（a）中原位产生的步骤（a）的反应混合物的脱水和任选地完成反应），导致产生脱水的反应混合物 ; C。 通过过滤从脱水反应混合物（b）和d分离得到的氯化物盐。 从过滤的液体馏分中分离出环氧化物。

    METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL
    4.
    发明申请
    METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL 有权
    合成替代HEXITOLS等作为二氢吡咯烷酮的方法

    公开(公告)号：US20150329511A1

    公开(公告)日：2015-11-19

    申请号：US14550131

    申请日：2014-11-21

    申请人： DEL MAR PHARMACEUTICALS

    发明人： Dennis M. BROWN ,  Mike Tso-Ping LI

    IPC分类号： C07D301/24 ,  C07D303/14 ,  C07C29/62

    CPC分类号： C07D301/24 ,  C07C29/62 ,  C07D303/14 ,  C07D493/04

    摘要： The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C. to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t-butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. Another method produces dianhydrogalactitol from dulcitol; this method comprises: (1) reacting dulcitol with a reactant to convert the 1,6-hydroxy groups of dulcitol to an effective leaving group to generate an intermediate; and (2) reacting the intermediate with an inorganic weak base to produce dianhydrogalactitol through an intramolecular SN2 reaction. Other methods for the synthesis of dianhydrogalactitol from dulcitol are described.

    摘要翻译： 本发明提供了合成和纯化二脱水己糖醇如二脱水半乳糖醇的有效方法。 通常，应用于二氢半乳糖醇时，该方法包括：（1）在约80℃的温度下使糊精与氢溴酸的浓缩溶液反应，生产二溴乳糖醇; （2）使二溴乳糖醇与碳酸钾在叔丁醇中反应，生成二脱水半乳糖; 和（3）使用乙醚的浆液纯化二脱水半乳糖醇以产生纯化的二脱水半乳糖醇。 另一种方法由二糖醇制得二脱水半乳糖醇; 该方法包括：（1）使杜仲醇与反应物反应，以将曲奇醇的1,6-羟基转化为有效的离去基团以产生中间体; 和（2）使中间体与无机弱碱反应，通过分子内SN2反应产生二脱水半乳糖。 描述了从杜尔醇醇合成二脱水半乳糖醇的其它方法。

    Preparation of α-hydroxy and α-amino ketones
    6.
    发明授权
    Preparation of α-hydroxy and α-amino ketones 有权
    α-羟基和α-氨基酮的制备

    公开(公告)号：US08252959B2

    公开(公告)日：2012-08-28

    申请号：US11631448

    申请日：2005-06-29

    申请人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    发明人： Nicole End ,  Reinhard H. Sommerlade ,  Yvonne Richter

    IPC分类号： C07C49/00 ,  C07C45/00 ,  C07D301/24

    CPC分类号： C07F7/1892 ,  C07C45/30 ,  C07C45/58 ,  C07C49/82 ,  C07C49/83 ,  C07C49/747 ,  C07C49/84

    摘要： A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alga as photoinitiators.

    摘要翻译： 公开了一种制备1,1-二取代的环氧乙烷的方法，其中有机硫化物在极性溶剂中与含有连接到伯或仲碳原子的离去基团的离子和/或在 在碱和极性溶剂的存在下，与酮反应。 所得类型的环氧乙烷可以通过在过渡金属催化剂的存在下进行好氧氧化，或者在水溶液存在下通过水解两步在一个步骤中进一步转化为相应的α-羟基酮或α-氨基酮 酸至相应的二醇并随后进行选择性氧化。 进一步描述了一些新型的环氧化物中间体。 因此获得的α-羟基酮和α-氨基酮可以作为光引发剂是有效的藻类。

    PROCESS FOR PRODUCING EPOXIDES
    8.
    发明申请
    PROCESS FOR PRODUCING EPOXIDES 有权
    生产环氧化物的方法

    公开(公告)号：US20100029958A1

    公开(公告)日：2010-02-04

    申请号：US12508435

    申请日：2009-07-23

    申请人： William W. Fan ,  Christian D. Kneupper ,  Sascha Noormann ,  Renate Patrascu

    发明人： William W. Fan ,  Christian D. Kneupper ,  Sascha Noormann ,  Renate Patrascu

    IPC分类号： C07D301/24

    CPC分类号： C07D301/26 ,  B01D3/009 ,  Y02P20/127

    摘要： A process for producing epoxides, the process including: (a) feeding at least one aqueous alkali and at least one halohydrin to a reactive distillation column; (b) concurrently in the reactive distillation column: (i) reacting at least a portion of the halohydrin with the alkali to form an epoxide; and (ii) stripping water and the epoxide from a basic aqueous residue; (c) recovering the water and the epoxide from the reactive distillation column as an overheads fraction; and, (d) condensing and phase separating the overheads fraction at a temperature of 50° C. or less to form an organic overheads fraction including the epoxide and an aqueous overheads fraction including water.

    摘要翻译： 一种制备环氧化物的方法，该方法包括：（a）将至少一种碱金属和至少一种卤代醇进料至反应性蒸馏塔; （b）在反应蒸馏塔中同时进行：（i）使至少一部分卤代醇与碱反应形成环氧化物; 和（ii）从碱性含水残余物中除去水和环氧化物; （c）从反应蒸馏塔中回收水和环氧化物作为塔顶馏分; 和（d）在50℃或更低的温度下冷凝和相分离塔顶馏分以形成包括环氧化物的有机塔顶馏分和包含水的塔顶馏分馏分。

    Process for preparing 1,3-dichloroacetone
    10.
    发明授权
    Process for preparing 1,3-dichloroacetone 有权
    1,3-二氯丙酮的制备方法

    公开(公告)号：US07361790B2

    公开(公告)日：2008-04-22

    申请号：US10588623

    申请日：2005-03-24

    申请人： Marvin L. Dettloff ,  Marty J. Null

    发明人： Marvin L. Dettloff ,  Marty J. Null

    IPC分类号： C07C45/63 ,  C07D301/02 ,  C07D301/24

    CPC分类号： C07C29/145 ,  C07C45/63 ,  C07C45/72 ,  C07D301/26 ,  C07D303/08 ,  C07C49/16 ,  C07C49/08 ,  C07C31/36

    摘要： Epichlorohydrin is produced from acetone by (1) chlorinating acetone to form monochloroacetone; (2) disproportionating the monochloroacetone in the presence of a platinum catalyst, a strong acid and preferably a chloride source (for example, added as a salt or from hydrolysis of monochloroacetone) and some water to produce acetone and 1,3-dichloroacetone; (3) hydrogenating the 1,3-dichloroacetone in the presence of a catalyst to produce 1,3-dichlorohydrin; and (4) cyclizing the 1,3-dichlorohydrin with a base to produce epichlorohydrin.

    摘要翻译： （1）氯化丙酮以形成一氯丙酮，由丙酮生成表氯醇; （2）在铂催化剂，强酸，优选氯化物源（例如以盐或加入一氯丙酮的水溶液）存在下歧化单氯代丙酮和一些水以产生丙酮和1,3-二氯丙酮; （3）在催化剂存在下氢化1,3-二氯丙酮以制备1,3-二氯丙醇; 和（4）用碱环化1,3-二氯丙醇以制备表氯醇。