公开(公告)号：US20240352037A1

公开(公告)日：2024-10-24

申请号：US18745209

申请日：2024-06-17

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

CPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US12054496B2

公开(公告)日：2024-08-06

申请号：US18334588

申请日：2023-06-14

申请人： Gilead Sciences, Inc.

发明人： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  Gregg M. Schwarzwalder ,  Devleena M. Shivakumar ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang

IPC分类号： C07D498/20 ,  A61K45/06 ,  A61P31/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  C07D513/22 ,  C07D515/22

CPC分类号： C07D498/20 ,  A61K45/06 ,  A61P31/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  C07D513/22 ,  C07D515/22 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds, of Formula I




Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US11964988B2

公开(公告)日：2024-04-23

申请号：US17274990

申请日：2019-09-06

申请人： ARRAY BIOPHARMA INC.

发明人： James F. Blake ,  Donghua Dai ,  Julia Haas ,  Yutong Jiang ,  Dean Kahn ,  Gabrielle R. Kolakowski ,  Elizabeth A. McFaddin ,  Megan L McKenney ,  Andrew T. Metcalf ,  David A. Moreno ,  Brett Prigaro ,  Ginelle A. Ramann ,  Li Ren ,  Shane M. Walls ,  Hailong Zhang

IPC分类号： C07D498/22 ,  A61K31/519 ,  A61K31/55 ,  A61K31/554 ,  A61K45/06 ,  A61P35/00 ,  C07D487/14 ,  C07D498/14 ,  C07D513/22

CPC分类号： C07D498/22 ,  A61K31/519 ,  A61K31/55 ,  A61K31/554 ,  A61K45/06 ,  A61P35/00 ,  C07D487/14 ,  C07D498/14 ,  C07D513/22

摘要： Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：US20240124486A1

公开(公告)日：2024-04-18

申请号：US18028363

申请日：2021-09-26

申请人： SHANGHAI VISONPHARMA CO., LTD.

发明人： Guozhi TANG ,  Dawei MA ,  Mengwei HUANG ,  Yongfu LIU ,  Yingyi WANG

IPC分类号： C07D498/22 ,  C07D487/22 ,  C07D513/22

CPC分类号： C07D498/22 ,  C07D487/22 ,  C07D513/22

摘要： A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.

公开(公告)号：US20240067660A1

公开(公告)日：2024-02-29

申请号：US17624949

申请日：2020-07-07

申请人： Janssen Pharmaceutica NV

发明人： Frederik Jan Rita ROMBOUTS ,  Gaston Stanislas Marcella DIELS ,  Soufyan JERHAOUI ,  Michel SURKYN ,  Yves Emiel Maria VAN ROOSBROECK ,  Matthieu Dominique JOUFFROY

IPC分类号： C07D513/18 ,  A61P35/00 ,  C07D513/22

CPC分类号： C07D513/18 ,  A61P35/00 ,  C07D513/22

摘要： The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.

公开(公告)号：US20230406861A1

公开(公告)日：2023-12-21

申请号：US18029625

申请日：2021-09-28

申请人： CYNORA GMBH

发明人： Ramin PASHAZADEH

IPC分类号： C07D487/22 ,  H10K50/11 ,  C09K11/06 ,  H10K85/60 ,  C07D471/22 ,  C07D498/22 ,  C07D513/22

CPC分类号： C07D487/22 ,  H10K50/11 ,  C09K11/06 ,  H10K85/6572 ,  C07D471/22 ,  C07D498/22 ,  C07D513/22 ,  H10K85/654 ,  C09K2211/1081 ,  C09K2211/1077 ,  H10K2101/20

摘要： The invention relates to an organic molecule for optoelectronic devices. According to the invention, the organic molecule has a structure of Formula I:






wherein
X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, X13, and X14 is independently selected from the group consisting of N and CRa; and
Z is at each occurrence independently selected from the group consisting of a direct bond, CR3R4, C═CR3R4, C═O, C═NR3, NR3, O, SiR3R4, S, S(O), and S(O)2.

公开(公告)号：US20230391795A1

公开(公告)日：2023-12-07

申请号：US18250267

申请日：2021-10-28

申请人： Merck Sharp & Dohme LLC

发明人： Kira A. Armacost ,  Maria Irina Chiriac ,  Danielle M. Hurzy ,  Jeffrey C. Kern ,  Jian Liu ,  Peter J. Manley ,  Vanessa L. Rada ,  Michael T. Rudd ,  Craig A. Stump ,  Zhe Wu ,  Dong Xiao

IPC分类号： C07D498/18 ,  C07D498/22 ,  C07D513/22

CPC分类号： C07D498/18 ,  C07D498/22 ,  C07D513/22

摘要： The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

公开(公告)号：US20230227473A1

公开(公告)日：2023-07-20

申请号：US17884154

申请日：2022-08-09

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hae Jung SON ,  Sungmin PARK ,  So Hyun PARK ,  Hyunjung JIN ,  Hyeonggeun YU ,  Jai Kyeong KIM ,  Seongwon YOON

IPC分类号： C07D513/22 ,  H01L51/42

CPC分类号： C07D513/22 ,  H01L51/4253

摘要： The present disclosure relates to a ternary photoactive layer composition and an organic solar cell including the same. According to the present disclosure, excessive crystal growth and aggregation can be prevented during large-area coating of a photoactive layer, uniform morphology can be achieved without significant phase separation, an organic solar cell with superior photovoltaic cell characteristics can be realized, and superior performance may be maintained even after long-term exposure to heat by preventing the morphological change of the photoactive layer.

公开(公告)号：US11584761B2

公开(公告)日：2023-02-21

申请号：US16992419

申请日：2020-08-13

申请人： Vertex Pharmaceuticals Incorporated

发明人： Paul Angell ,  John E. Cochran ,  Benjamin J. Littler ,  David Siesel ,  Armando Urbina ,  Corey Don Anderson ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Timothy Richard Coon ,  Bryan Frieman ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Pierre ,  Sara E. Swift ,  Jinglan Zhou

IPC分类号： C07D513/22 ,  C07D207/08 ,  C07D213/71 ,  C07D213/82 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14

摘要： The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

公开(公告)号：US20220071971A1

公开(公告)日：2022-03-10

申请号：US17415335

申请日：2019-12-18

申请人： NOVARTIS AG

发明人： Mihai Azimioara ,  Badry Bursulaya ,  Songchun Jiang ,  Casey Jacob Nelson MATHISON ,  Victor Ivanovich NIKULIN ,  Truc Ngoc NGUYEN ,  Barun OKRAM ,  Sejal PATEL ,  Dean Paul PHILLIPS ,  Lewis WHITEHEAD ,  Baogen WU ,  Shanshan YAN ,  Xuefeng ZHU

IPC分类号： A61K31/439 ,  A61K45/06 ,  C07D515/18 ,  C07D513/22 ,  C07D513/18 ,  A61K31/5377

摘要： The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.