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    Methods and apparatus for spectroscopic identification and/or calibrated quantification of surface concentration of materials
    5.
    发明授权
    Methods and apparatus for spectroscopic identification and/or calibrated quantification of surface concentration of materials 有权

    公开(公告)号：US10732037B1

    公开(公告)日：2020-08-04

    申请号：US16290002

    申请日：2019-03-01

    Applicant: Photon Systems, Inc.

    Inventor： Michael R. Reid

    IPC: G01J3/28 ,  G01J3/02 ,  C12Q1/24 ,  C12Q1/08

    Abstract: Apparatus and methods for creating deposits of uniformly spaced or uniformly overlapping droplets of selected chemicals where each droplet has an a priori known amount of the selected chemical or chemicals is taught (including biological and microbial materials). In some embodiments the deposits may be used as samples of different but known concentrations that may be used to calibrate spectroscopic inspection instruments to enable such instruments to not only provide identification in situ of unknown materials but also to provide calibrated and traceable surface concentrations of such materials. In some embodiments, such calibrated instruments may be used in enhanced processes for validating the cleanliness of manufacturing surfaces such as surfaces of equipment used in the preparation of pharmaceuticals, food, or semiconductor devices. Such instruments may be used to ensure adequate purity, or non-contamination, of surfaces of products themselves or packaging materials or of locations where such products will be used. Such calibrated instruments may also be useful in detecting cleanliness of non-manufacturing surfaces where contamination may be of concern, whether they be public or private spaces such as laboratories, restaurants, airports, satellites or other spacecraft. In some embodiments, such instruments may range from deep UV instruments to far infrared instruments or beyond.

    Rapid and sensitive detection of bacteria in blood products, urine, and other fluids
    6.
    发明授权
    Rapid and sensitive detection of bacteria in blood products, urine, and other fluids 有权

    公开(公告)号：US09260737B2

    公开(公告)日：2016-02-16

    申请号：US13572621

    申请日：2012-08-11

    Applicant: Kyle R. Brandy ,  Daniel G. Ericson

    Inventor： Kyle R. Brandy ,  Daniel G. Ericson

    IPC: C12Q1/04 ,  C12Q1/66 ,  C12Q1/08 ,  C12Q1/00

    CPC classification number: C12Q1/04 ,  C12Q1/008 ,  C12Q1/66

    Abstract: The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts of ATP. Thus, some of the methods involve separating intact eukaryotic cells (e.g., platelets) from intact bacterial cells before lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme that catalyzes a reaction, and monitoring the enzyme-catalyzed reaction. Typically, the enzyme is luciferin, and the reaction is monitored by detecting light produced by the luciferin. Other methods of the invention involve contacting a fluid sample with a support surface that binds bacterial cells, lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme, and monitoring the enzyme-catalyzed reaction. Apparatuses for carrying out the methods are also disclosed.

    Method of measuring lipoarabinomannan and application thereof
    10.
    发明授权
    Method of measuring lipoarabinomannan and application thereof 有权
    测量脂多巴胺甘露聚糖的方法及其应用

    公开(公告)号：US08703412B2

    公开(公告)日：2014-04-22

    申请号：US12905685

    申请日：2010-10-15

    Applicant: Shigenori Tanaka ,  Shoji Takahashi

    Inventor： Shigenori Tanaka ,  Shoji Takahashi

    IPC: C12Q1/04 ,  C12Q1/06 ,  C12Q1/08 ,  G01N33/92

    CPC classification number: G01N33/579 ,  G01N33/56911 ,  G01N2400/50

    Abstract: A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample; a method for removing reactivity of LAM with a Limulus reagent, which comprises at least a step of allowing a predetermined substance to coexist with a LAM-containing sample; a method for measuring Et in a LAM-containing sample and a method for detecting an Et-related disease, which each is a method for measuring an endotoxin using a Limulus reagent, which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the above-described removing method; a method for measuring BG in a LAM-containing sample and a method for detecting mycosis, which is a method for measuring BG using a Limulus reagent, which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the described-described removing method; and the like.

    Abstract translation: 一种用于测量LAM的方法和一种用于检测耐酸细菌的方法，其至少包括允许鲎试剂与含LAM的样品接触的步骤; 用于除去LAM与鲎试剂的反应性的方法，该方法至少包括允许预定物质与含LAM的样品共存的步骤; 用于测量含LAM的样品中的Et的方法和用于检测Et相关疾病的方法，其各自是使用鲎试剂测量内毒素的方法，该方法至少包括除去LAM与鲎的反应性的步骤 试剂通过上述去除方法; 用于测量含有LAM的样品中的BG的方法和用于检测真菌病的方法，该方法是使用鲎试剂测量BG的方法，该方法至少包括通过上述描述的方法除去LAM与鲎试剂的反应性的步骤 去除方法; 等等。

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