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公开(公告)号：US20180072982A1
公开(公告)日：2018-03-15
申请号：US15560048
申请日：2016-03-30
Applicant: BD KIESTRA B.V. , BD KIESTRA B.V.
Inventor： Martijn Xander BERNTSEN , Jurjen SINNEMA , Martijn Kleefstra
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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公开(公告)号：US20240361214A1
公开(公告)日：2024-10-31
申请号：US18754887
申请日：2024-06-26
Applicant: BD KIESTRA B.V.
Inventor： Timothy Roy Hansen , Martijn Kleefstra , Michael Bois , Timothy M. Wiles , Charles Chak Cheung Yu
CPC classification number: G01N1/38 , C12Q1/18 , C12Q1/24 , G01N1/40 , G01N2001/386
Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
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公开(公告)号：US11884959B2
公开(公告)日：2024-01-30
申请号：US17698518
申请日：2022-03-18
Applicant: BD KIESTRA B.V.
Inventor： Raphael Rodolphe Marcelpoil
CPC classification number: C12Q1/18 , C12Q1/20 , G01N21/17 , G06T7/0016 , G06T7/11 , G06T7/90 , G06V20/69 , G06V20/693 , G06V20/695
Abstract: An imaging system and method provides automated microbial growth detection for antibiotic sensitivity testing. A processing system having an image sensor for capturing images of an inoculated culture plate having antibiotic disks disposed on the culture media captures images of the plate at separate times (e.g., first and second images). The system generates pixel characteristic data for pixels of the second image from a comparison of the first image and second image. The pixel characteristic data may be indicative of plate growth. The system may access growth modeling data concerning the antibiotic disk(s) and generate simulated image data with a growth model function. The growth model function uses the growth modeling data. The simulated image data simulates growth on the plate relative to the disk(s). The system compares the simulated image and the pixel characteristic data to identify pixel region(s) of the second image that differ from the simulated image.
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4.发明公开公开(公告)号：US20230383232A1
公开(公告)日：2023-11-30
申请号：US18142764
申请日：2023-05-03
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael R. Marcelpoil
CPC classification number: C12M41/36 , G06T7/0016 , C12Q1/02 , G06V20/695 , G06V20/698 , G06T2207/10056 , G06T2207/30024
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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公开(公告)号：US20230250388A1
公开(公告)日：2023-08-10
申请号：US18133561
申请日：2023-04-12
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
CPC classification number: C12M47/02 , G01N35/0099 , C12M33/04 , G01N35/1011 , C12M33/02 , C12M41/48 , C12N1/02 , C12Q1/24 , G01N35/10 , G01N2001/028
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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Patent Agency Ranking
公开(公告)号：US11136544B2
公开(公告)日：2021-10-05
申请号：US16699884
申请日：2019-12-02
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander Berntsen , Jurjen Sinnema , Martijn Kleefstra
IPC: C12M1/00 , C12M1/36 , C12N1/02 , C12Q1/24 , G01N35/00 , G01N35/10 , C12M1/26 , C12M1/30 , G01N1/02
Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
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公开(公告)号：US20210239582A1
公开(公告)日：2021-08-05
申请号：US17235171
申请日：2021-04-20
Applicant: BD KIESTRA B.V.
Inventor： Martijn Xander BERNTSEN , Martijn Kleefstra , Roger Petri , Tino Walter Van Der Zee
Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
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公开(公告)号：US20210116471A1
公开(公告)日：2021-04-22
申请号：US17136670
申请日：2020-12-29
Applicant: BD KIESTRA B.V.
Inventor： Timothy R. Hansen , Rick Holtz , Martijn Kleefstra , Raphael Rodolphe Marcelpoil , Rick Pierpont , Brent Ronald Pohl , Alyssa Shedlosky , Scott Shindledecker , Edward Skevington , Kerry Lynn Smith , Timothy Wiles
Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample. The apparatus and system optionally provide for downstream processing of samples prepared for antibiotic susceptibility testing (AST). Such apparatus includes further processing after inoculation of an AST panel for the AST test. Such further processing includes capping and transferring inoculated panels to AST instrument.
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公开(公告)号：US20210055318A1
公开(公告)日：2021-02-25
申请号：US17094178
申请日：2020-11-10
Applicant: BD KIESTRA B.V.
Inventor： Jetze Botma , Martijn Kleefstra , Tino Walter Van der Zee
Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.
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公开(公告)号：US10859588B2
公开(公告)日：2020-12-08
申请号：US16668656
申请日：2019-10-30
Applicant: BD KIESTRA B.V.
Inventor： Jetze Botma , Martijn Kleefstra , Tino Walter Van der Zee
Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.
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