公开(公告)号：WO2008057203A2

公开(公告)日：2008-05-15

申请号：PCT/US2007022428

申请日：2007-10-23

Applicant: DURAMED PHARMACEUTICALS INC ,  CHOWDHURY TAHSEEN A ,  GABRIELSKI EDWARD J ,  BAKER CHRISTOPHER H

Inventor： CHOWDHURY TAHSEEN A ,  GABRIELSKI EDWARD J ,  BAKER CHRISTOPHER H

IPC: A23G3/12 ,  A61J7/00

CPC classification number: A23G3/125 ,  A61J7/003 ,  A61K9/0056 ,  A61K9/2031 ,  A61K9/2095 ,  B29C65/645 ,  B29C65/7841 ,  B29C66/126 ,  B29C66/534 ,  B29C66/71 ,  B29C66/73773 ,  B29C66/7392 ,  B29C66/7394 ,  B29C66/8161 ,  B29C66/8322 ,  B29C66/843 ,  B29K2021/00 ,  B29K2021/003 ,  B29K2023/00 ,  B29K2101/12 ,  B29K2995/004 ,  B29L2031/753 ,  Y10T29/49826 ,  Y10T29/49828 ,  Y10T29/49829 ,  Y10T29/49966 ,  Y10T29/53435 ,  B29K2067/00 ,  B29K2055/02

Abstract: A method for attaching a handle to a tablet to form a lollipop utilizes a specific work holder. The work holder has a tooling pallet with a plurality of openings going from a top surface to a bottom surface. A bullet and a spring are located in each opening and held in place by a plate that slides through a groove in the bottom surface of the tooling pallet to block the openings in the bottom surface. Each spring is positioned between a bullet and the plate. A tablet is placed in a cavity of each bullet and a handle is placed in contact with each tablet. High frequency mechanical vibrations, such as ultrasonic vibrations, are applied to a joint interface between each tablet and bullet until the joint interface reaches a molten state. The joint interfaces are then allowed to cool, thereby attaching a handle to each tablet and forming a lollipop.

Abstract translation: 用于将手柄附接至平板电脑以形成棒棒糖的方法利用特定的工作架。 工件夹具具有工具托盘，工具托盘具有从顶表面到底表面的多个开口。 子弹和弹簧位于每个开口中，并且通过滑动通过工具托盘底面中的凹槽的平板保持就位，以阻挡底面的开口。 每个弹簧都位于子弹和盘子之间。 将平板电脑置于每个子弹的空腔中，并将手柄放置成与每个平板电脑接触。 高频机械振动，例如超声波振动，被施加到每个片剂和子弹之间的接合界面处，直到接合界面达到熔融状态。 然后使接合界面冷却，由此将手柄附接到每个平板电脑并形成棒棒糖。

公开(公告)号：WO2014078576A3

公开(公告)日：2014-07-10

申请号：PCT/US2013070162

申请日：2013-11-14

Applicant: ABON PHARMACEUTICALS LLC ,  AHMED SALAH U ,  ZU YANMING ,  NEELAM KARUNAKAR ,  MUNTAZIM SAAD ,  CHOWDHURY TAHSEEN A ,  TIAN SHIYING

Inventor： AHMED SALAH U ,  ZU YANMING ,  NEELAM KARUNAKAR ,  MUNTAZIM SAAD ,  CHOWDHURY TAHSEEN A ,  TIAN SHIYING

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30

CPC classification number: A61K31/568 ,  A61J3/06 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/205 ,  A61K31/565 ,  A61K31/566 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  B65D75/36

Abstract: This invention relates to dosage forms for the delivery of drugs across the oral mucosa having improved transmucosal permeability. More specifically, the invention relates to an oral transmucosal dosage form comprising a primary vehicle comprising a crystallization inhibition agent (CIA) system and a drug, and a secondary vehicle. It also relates to methods of designing and making this dosage form, methods of administering this dosage form and methods of packaging the dosage forms.

Abstract translation: 本发明涉及通过具有改善的经粘膜渗透性的口腔粘膜递送药物的剂型。 更具体地，本发明涉及包含含有结晶抑制剂（CIA）系统和药物的主要载体的口腔粘膜剂型，以及二级载体。 它还涉及设计和制备该剂型的方法，给予该剂型的方法和包装剂型的方法。

公开(公告)号：WO2008024406A3

公开(公告)日：2008-08-07

申请号：PCT/US2007018583

申请日：2007-08-23

Applicant: DURAMED PHARMACEUTICALS INC ,  SCULLY SEAN ,  CHOWDHURY TAHSEEN A

Inventor： SCULLY SEAN ,  CHOWDHURY TAHSEEN A

IPC: B30B11/08

CPC classification number: B29C43/08 ,  A61J3/10 ,  B29C33/30 ,  B29C43/003 ,  B29C2043/3618 ,  B29C2043/3665 ,  B29C2043/3681 ,  B30B11/08

Abstract: A tabletting press for making compressed products that includes an upper punch, a lower punch, a die and a core pin. The core pin is located in the lower punch and moves with respect to the lower punch. Movement of the upper punch and the lower punch toward each other within the die and the location of the core pin create a compressed product having a hole. The product may be a lollipop containing a pharmaceutical.

Abstract translation: 一种用于制造包括上冲头，下冲头，模具和芯销的压缩产品的压片机。 芯销位于下冲头中，相对于下冲头移动。 模具内的上冲头和下冲头彼此移动，并且芯销的位置产生具有孔的压缩产品。 该产品可以是含有药物的棒棒糖。

公开(公告)号：WO2008079245A3

公开(公告)日：2008-12-04

申请号：PCT/US2007025974

申请日：2007-12-20

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  SETHIA SUNDEEP ,  CHOWDHURY TAHSEEN A

Inventor： AHMED SALAH U ,  SETHIA SUNDEEP ,  CHOWDHURY TAHSEEN A

IPC: A61K9/20

CPC classification number: A61K31/56 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2054

Abstract: The present invention is directed to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising progestin and methods of making and using the dosage forms to treat conditions in females in need thereof.

Abstract translation: 本发明涉及包含孕酮的非泡腾，口腔崩解固体药物剂型以及制备和使用该剂型以治疗有需要的雌性病症的方法。

公开(公告)号：WO2008057203A3

公开(公告)日：2008-05-15

申请号：PCT/US2007/022428

申请日：2007-10-23

Applicant: DURAMED PHARMACEUTICALS, INC. ,  CHOWDHURY, Tahseen, A. ,  GABRIELSKI, Edward, J. ,  BAKER, Christopher, H.

Inventor： CHOWDHURY, Tahseen, A. ,  GABRIELSKI, Edward, J. ,  BAKER, Christopher, H.

IPC: A23G3/12 ,  A61J3/00 ,  A61J7/00 ,  B29C65/64 ,  B30B11/02 ,  A61K9/20

Abstract: A method for attaching a handle to a tablet to form a lollipop utilizes a specific work holder. The work holder has a tooling pallet with a plurality of openings going from a top surface to a bottom surface. A bullet and a spring are located in each opening and held in place by a plate that slides through a groove in the bottom surface of the tooling pallet to block the openings in the bottom surface. Each spring is positioned between a bullet and the plate. A tablet is placed in a cavity of each bullet and a handle is placed in contact with each tablet. High frequency mechanical vibrations, such as ultrasonic vibrations, are applied to a joint interface between each tablet and bullet until the joint interface reaches a molten state. The joint interfaces are then allowed to cool, thereby attaching a handle to each tablet and forming a lollipop.

公开(公告)号：WO2008024406A2

公开(公告)日：2008-02-28

申请号：PCT/US2007/018583

申请日：2007-08-23

Applicant: DURAMED PHARMACEUTICALS, INC. ,  SCULLY, Sean ,  CHOWDHURY, Tahseen, A.

Inventor： SCULLY, Sean ,  CHOWDHURY, Tahseen, A.

IPC: B30B11/08 ,  B30B15/06

CPC classification number: B29C43/08 ,  A61J3/10 ,  B29C33/30 ,  B29C43/003 ,  B29C2043/3618 ,  B29C2043/3665 ,  B29C2043/3681 ,  B30B11/08

Abstract: A tabletting press for making compressed products that includes an upper punch, a lower punch, a die and a core pin. The core pin is located in the lower punch and moves with respect to the lower punch. Movement of the upper punch and the lower punch toward each other within the die and the location of the core pin create a compressed product having a hole. The product may be a lollipop containing a pharmaceutical.

Abstract translation: 用于制造压制产品的压片机，包括上冲头，下冲头，模具和芯销。 芯销位于下冲头中并相对于下冲头移动。 上冲头和下冲头在模具内相互移动以及芯销的位置产生具有孔的压缩产品。 该产品可能是含有药物的棒棒糖。

公开(公告)号：WO2007109247A3

公开(公告)日：2008-02-28

申请号：PCT/US2007006850

申请日：2007-03-20

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  CHOWDHURY TAHSEEN A ,  LUO YI

Inventor： AHMED SALAH U ,  CHOWDHURY TAHSEEN A ,  LUO YI

IPC: A61B1/303

CPC classification number: A61K9/0036 ,  A61K31/00 ,  A61K31/20 ,  A61K38/00

Abstract: The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.

Abstract translation: 本发明涉及柔性压缩阴道内环，其包含基本均匀的压缩混合物，其包含聚甲基丙烯酸酯，增塑剂和活性剂，以及制备和使用它们的方法及其制备方法。

公开(公告)号：WO2007109247A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006850

申请日：2007-03-20

Applicant: DURAMED PHARMACEUTICALS, INC. ,  AHMED, Salah, U. ,  CHOWDHURY, Tahseen, A. ,  LUO, Yi

Inventor： AHMED, Salah, U. ,  CHOWDHURY, Tahseen, A. ,  LUO, Yi

IPC: A61K31/20 ,  A61K38/00 ,  A61K38/43 ,  A61K9/02

CPC classification number: A61K9/0036 ,  A61K31/00 ,  A61K31/20 ,  A61K38/00

Abstract: The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.

Abstract translation: 本发明涉及柔性压缩阴道内环，其包含基本均匀的压缩混合物，其包含聚甲基丙烯酸酯，增塑剂和活性剂，以及制备和使用它们的方法及其制备方法。

公开(公告)号：WO2006127879A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/020203

申请日：2006-05-25

Applicant: DURAMED PHARMACEUTICALS, INC. ,  AHMED, Salah, U. ,  LI, Lianli ,  CHOWDHURY, Tahseen A.

Inventor： AHMED, Salah, U. ,  LI, Lianli ,  CHOWDHURY, Tahseen A.

IPC: A61K9/00 ,  A61K9/20 ,  A23L1/05 ,  A23G3/32 ,  A23G3/36 ,  A23G3/44

CPC classification number: A23G3/36 ,  A23P10/28 ,  A61K9/0034 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2063 ,  A61K9/2095

Abstract: The present invention provides flexible solid dosage forms that include an active agent, gelatin, and a polyol or saccharide. The present invention also provides methods of making flexible solid dosage forms.

Abstract translation: 本发明提供了柔性固体剂型，其包括活性剂，明胶和多元醇或糖。 本发明还提供制备柔性固体剂型的方法。

公开(公告)号：WO2014078576A2

公开(公告)日：2014-05-22

申请号：PCT/US2013/070162

申请日：2013-11-14

Applicant: ABON PHARMACEUTICALS, LLC ,  AHMED, Salah, U. ,  ZU, Yanming ,  NEELAM, Karunakar ,  MUNTAZIM, Saad ,  CHOWDHURY, Tahseen, A. ,  TIAN, Shiying

Inventor： AHMED, Salah, U. ,  ZU, Yanming ,  NEELAM, Karunakar ,  MUNTAZIM, Saad ,  CHOWDHURY, Tahseen, A. ,  TIAN, Shiying

IPC: A61K47/44 ,  A61K31/568 ,  A61K31/565 ,  A61K47/22 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K9/00

CPC classification number: A61K31/568 ,  A61J3/06 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/205 ,  A61K31/565 ,  A61K31/566 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  B65D75/36

Abstract: This invention relates to dosage forms for the delivery of drugs across the oral mucosa having improved transmucosal permeability. More specifically, the invention relates to an oral transmucosal dosage form comprising a primary vehicle comprising a crystallization inhibition agent (CIA) system and a drug, and a secondary vehicle. It also relates to methods of designing and making this dosage form, methods of administering this dosage form and methods of packaging the dosage forms.

Abstract translation: 本发明涉及用于跨越口腔粘膜递送药物的剂型，其具有改善的透粘膜通透性。 更具体地说，本发明涉及口服透粘膜剂型，其包含含有结晶抑制剂（CIA）系统和药物的主要媒介物以及辅助媒介物。 它还涉及设计和制备该剂型的方法，给予该剂型的方法和包装剂型的方法。