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    ELECTROKINETIC CONFINEMENT OF NEURITE GROWTH FOR DYNAMICALLY CONFIGURABLE NEURAL NETWORKS
    1.
    发明申请
    ELECTROKINETIC CONFINEMENT OF NEURITE GROWTH FOR DYNAMICALLY CONFIGURABLE NEURAL NETWORKS 审中-公开
    用于动态配置神经网络的神经生长电动机制

    公开(公告)号：WO2014110559A1

    公开(公告)日：2014-07-17

    申请号：PCT/US2014/011444

    申请日：2014-01-14

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

    Inventor： VOLDMAN, Joel ,  HONEGGER, Thibault ,  PEYRADE, David

    IPC: A61N1/20 ,  A61N1/32 ,  C12M3/00 ,  C12M1/00 ,  C12M1/42 ,  C12N5/0793 ,  C12N13/00 ,  G01N33/50 ,  B82Y15/00 ,  B03C5/00 ,  B01L3/00

    CPC classification number: C12N13/00 ,  A61N1/205 ,  A61N1/326 ,  B01L3/5027 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  C12M21/08 ,  C12M23/34 ,  C12M35/02 ,  C12M35/04 ,  C12N5/0619 ,  C12N2529/00 ,  C12N2533/54 ,  C12N2535/00

    Abstract: Systems and methods for altering neurite growth are generally described. In some embodiments, a system may include a neuron comprising a neurite and electrodes able to generate a physical guidance cue. The physical guidance cue may be used to alter the growth of the neurite and may be temporally and spatially dynamic, such that neurite growth may be altered in a spatial and/or temporal manner. Dynamic control of neurite growth may be used to form directional neural connections, intersections, and/or overlaps. The system combrises a chamber capable of housing a living cell and promoting cell growth; a channel, wherein the channel is connected to the chamber, wherein the channel has a height and/or width of less than or equal to about 20 microns; and at least one electrode pair intersecting the channel with a center to center spacing of the electrodes of less than or equal to about 200 microns, and wherein the plurality of electrode pairs intersects the channel.

    Abstract translation: 通常描述用于改变神经突生长的系统和方法。 在一些实施例中，系统可以包括神经元，其包括神经突和能够产生物理引导提示的电极。 身体引导提示可以用于改变神经突的生长并且可以在时间和空间上动态，使得神经突生长可以以空间和/或时间方式改变。 可以使用神经突生长的动态控制来形成方向性神经连接，交叉点和/或重叠。 该系统包含能够容纳活细胞并促进细胞生长的室; 通道，其中所述通道连接到所述室，其中所述通道具有小于或等于约20微米的高度和/或宽度; 以及至少一个与所述通道相交的电极对，其电极的中心到中心间隔小于或等于约200微米，并且其中所述多个电极对与所述通道相交。

    MICROFLUIDIC ELECTROCHEMICAL ANALYTE DETECTORS
    2.
    发明申请
    MICROFLUIDIC ELECTROCHEMICAL ANALYTE DETECTORS 审中-公开

    公开(公告)号：WO2022020202A1

    公开(公告)日：2022-01-27

    申请号：PCT/US2021/042003

    申请日：2021-07-16

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： WU, Dan ,  VOLDMAN, Joel

    IPC: B01L3/00

    Abstract: Microfluidic chips containing electrochemical biosensors are described. The electrochemical biosensors include a flow layer intersected by valves of a control layer, which control the fluid flow. The flow layer includes two zones, an analyte capture zone for mixing a sample with an analyte capture element, and a detection zone for detecting the analyte. Both zones include a rotary mixer for mixing, and where needed, trapping, washing, and flowing the captured analyte. The captured analyte is detected by the sensing region of the detection zone. The microfluidic chips may be integrated into devices for automated, fast, point-of-care determination of analyte concentration.

    METHOD AND APPARATUS FOR TRACKING CELL IDENTITY
    4.
    发明申请
    METHOD AND APPARATUS FOR TRACKING CELL IDENTITY 审中-公开
    跟踪细胞识别的方法和装置

    公开(公告)号：WO2015061719A1

    公开(公告)日：2015-04-30

    申请号：PCT/US2014/062231

    申请日：2014-10-24

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： CASTELLARNAU, Marc ,  SZETO, Gregory, Lee ,  IRVINE, Darrell ,  LOVE, John, Christopher ,  VOLDMAN, Joel

    IPC: C12Q1/68

    CPC classification number: G01N15/1463 ,  G01N15/10 ,  G01N15/1484 ,  G01N35/00732 ,  G01N2015/0065 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2035/00811 ,  G01N2035/00831

    Abstract: A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtitre plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.

    Abstract translation: 通过分析平台跟踪细胞身份的方法使用随机条形码（SB）。 SB使用随机生成的代码，其基于与感兴趣的一组单元格一起封装的珠的数量，颜色和位置中的一个或多个。 SB的使用在其中将细胞从微孔阵列转移到微量滴定板同时保持其同一性的应用中得到证明，并且获得了100个块的转移的平均识别精度为96％。 该方法的模型缩放高达1000块，证明SB能够实现大约90％的精度。

    PARTICLE CAPTURE DEVICES AND METHODS OF USE THEREOF
    7.
    发明申请
    PARTICLE CAPTURE DEVICES AND METHODS OF USE THEREOF 审中-公开
    颗粒捕获装置及其使用方法

    公开(公告)号：WO2009102783A1

    公开(公告)日：2009-08-20

    申请号：PCT/US2009/033785

    申请日：2009-02-11

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  WHITEHEAD INSTITUTE ,  VOLDMAN, Joel ,  SKELLEY, Alison, M. ,  KIRAK, Oktay ,  JAENISCH, Rudolf

    Inventor： VOLDMAN, Joel ,  SKELLEY, Alison, M. ,  KIRAK, Oktay ,  JAENISCH, Rudolf

    IPC: C12Q1/68

    CPC classification number: G01N33/5005 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/16 ,  B01L2400/0421 ,  B01L2400/0424

    Abstract: The present invention provides a device and methods of use thereof in microscale particle capturing and particle pairing. This invention provides particle patterning device, which mechanically traps individual particles within first chambers of capture units, transfer the particles to second chambers of opposing capture units, and traps a second type of particle in the same second chamber. The device and methods allow for high yield assaying of trapped cells, high yield fusion of trapped, paired cells, for controlled binding of particles to cells and for specific chemical reactions between particle interfaces and particle contents. The device and method provide means of identification of the particle population and a facile route to particle collection.

    Abstract translation: 本发明提供了一种在微粒子捕获和粒子配对中使用的装置及其使用方法。 本发明提供了颗粒图案形成装置，其将捕获单元的第一室内的各个颗粒机械捕获，将颗粒转移到相对的捕获单元的第二室，并将第二类型的颗粒捕集在相同的第二室中。 该装置和方法允许捕获细胞的高产量测定，捕获的成对细胞的高产量融合，用于颗粒与细胞的受控结合以及颗粒界面和颗粒含量之间的特定化学反应。 该装置和方法提供了识别粒子群体的方法和容易的粒子收集途径。

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