公开(公告)号：WO2017172609A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/024289

申请日：2017-03-27

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  SLAGER, Joram ,  MCGONIGLE, Joseph Schmidt ,  LOCKWOOD, Nathan A.

IPC: A61M25/06 ,  A61M25/00

CPC classification number: A61M25/0662 ,  A61M25/0023 ,  A61M25/0045 ,  A61M25/0097 ,  A61M25/0668 ,  A61M39/06 ,  A61M2025/0024 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/006 ,  A61M2025/0681 ,  A61M2025/0687 ,  A61M2039/064 ,  A61M2039/0666 ,  A61M2207/00

Abstract: An insertion tool 100 for inserting a medical device into another medical device, such as a hemostasis sealing valve. The insertion tool includes a guide sheath 101 and a protection tube 105. The guide sheath includes a flared proximal end. The guide sheath can further include a central lumen. The guide sheath further includes a locking notch 104 disposed on the inner surface between the proximal end and the distal end. The protection tube includes a flared proximal end 108. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube is sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

Abstract translation: 用于将医疗装置插入另一医疗装置（例如止血密封阀）中的插入工具100。 插入工具包括引导护套101和保护管105.引导护套包括扩大的近端。 引导护套可以进一步包括中央内腔。 引导护套还包括设置在近端和远端之间的内表面上的锁定凹口104。 保护管包括张开的近端108.保护管的一部分可以位于引导护套的中心腔内。 保护管的张开的近端的尺寸设置成配合在锁定凹口内并且可以具有比紧邻锁定凹口的内表面的部分更大的外径。 其他实施例也包括在本文中。

公开(公告)号：WO2016053831A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/052565

申请日：2015-09-28

Applicant: SURMODICS, INC.

Inventor： CHAPPA, Ralph A. ,  LOCKWOOD, Nathan A. ,  MCGONIGLE, Joseph Schmidt

IPC: A61L29/04 ,  A61L29/08 ,  A61L29/14 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L29/14 ,  A61L29/049 ,  A61L29/085 ,  A61L31/041 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/06 ,  C08J3/203 ,  C08J2375/04 ,  C08J2429/10 ,  C08J2437/00 ,  C08L73/02 ,  C08L75/04

Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties.In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

Abstract translation: 本发明的实施例包括由具有光滑性质的聚合物形成的医疗装置元件。在一个实施例中，包括形成医疗装置元件的方法。 该方法可以包括混合第一聚合物组分和第二聚合物组分以形成聚合物混合物。 该方法还可以包括将聚合物混合物形成到医疗装置元件中。 该方法还可以包括用酸或碱中的至少一种处理聚合物混合物。 在一个实施例中，包括医疗装置。 医疗装置可以包括润滑元件，润滑元件包括第一聚合物组分和第二聚合物组分的混合物。 第二聚合物组分可以包括在形成元素之后用至少一种酸或碱处理的聚合物。 本文还包括其它实施例。

公开(公告)号：WO2014071387A1

公开(公告)日：2014-05-08

申请号：PCT/US2013/068539

申请日：2013-11-05

Applicant: SURMODICS, INC.

Inventor： VENTURA, Joseph ,  WADMAN, Shannon ,  SLAGER, Joram ,  MCGONIGLE, Joseph Schmidt ,  HERGENROTHER, Robert W.

IPC: A61K47/34 ,  A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  A61K31/337

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

公开(公告)号：WO2016154541A1

公开(公告)日：2016-09-29

申请号：PCT/US2016/024228

申请日：2016-03-25

Applicant: SURMODICS, INC. ,  BURTON, Kevin W.

Inventor： BURTON, Kevin W. ,  MCGONIGLE, Joseph Schmidt ,  KURDYUMOV, Aleksey V. ,  MISSLING, Jeffrey J. ,  LOCKWOOD, Nathan A. ,  PETERSEN, Beth A.

IPC: A61L27/18 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/07 ,  C08L67/04

CPC classification number: A61L31/10 ,  A61L27/18 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/602

Abstract: A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein.

Abstract translation: 描述了用于从可植入医疗装置输送一种或多种生物活性剂的生物相容性聚合物控制释放基质屏障结构。 在一个实施方案中，包括生物相容性聚合物控制释放基质屏障结构。 生物相容性聚合物控释基质可以包括由包含一种或多种顺应性生物相容性聚合物和一种或多种生物活性剂的柔顺材料形成的体结构。 身体结构可以限定可植入医疗装置的皮下元件通过的中心孔。 其他实施例包括在本文中。

公开(公告)号：WO2014110407A3

公开(公告)日：2014-07-17

申请号：PCT/US2014/011096

申请日：2014-01-10

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  KURDYUMOV, Aleksey V. ,  MCGONIGLE, Joseph Schmidt ,  HERGENROTHER, Robert W. ,  LOCKWOOD, Nathan A. ,  VENTURA, Joseph ,  STUCKE, Sean M.

IPC: A61B5/04 ,  A61N1/04 ,  A61N1/05 ,  C08G61/12 ,  C07D495/04 ,  C07D519/00 ,  C09D5/24 ,  C08G61/02 ,  C08G73/02 ,  H01B1/12

Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers and polymers are described and electrically conductive coatings that include activatable conductive polymers.

Abstract translation: 本文公开了可活化的导电组合物和制备和使用可活化的导电组合物的方法。 具体而言，描述了可活化的导电单体和聚合物以及包含可活化导电聚合物的导电涂层。