公开(公告)号：WO2016038357A1

公开(公告)日：2016-03-17

申请号：PCT/GB2015/052597

申请日：2015-09-08

Applicant: EULYSIS UK LIMITED

Inventor： TSAKAS, Spyridon Edouard ,  TSAKAS, Spyridon Christos

IPC: B01L3/00 ,  B65D47/36 ,  A61J1/20 ,  A61J1/14 ,  B65D51/24 ,  B65D51/28 ,  B65B29/10

CPC classification number: A61J1/2072 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/2027 ,  A61J1/2075 ,  A61J1/2093 ,  A61J1/2096 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/00 ,  A61K38/43 ,  A61K39/00 ,  A61M11/00 ,  B01L3/502 ,  B01L3/523 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0672 ,  B65B7/28 ,  B65B29/10 ,  B65B55/02 ,  B65B63/08 ,  B65D51/002 ,  B65D51/241 ,  B65D51/2814 ,  B65D51/2835

Abstract: A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

Abstract translation: 用于将一种或多种活性剂分配到容器中的封闭件包括具有可破裂壁的密封或可密封的室和可滑动地安装在活塞导向件中的中空活塞。 所述中空活塞包括在所述腔室中具有一端的外壁和至少一个通气孔。 所述端部具有切割结构。 所述中空活塞可在活塞引导件中在通气位置之间滑动，在通风位置中，所述至少一个通气孔允许腔室的通气和密封位置，在所述密封位置中，所述至少一个通气孔被密封，以防止腔室的通气和展开位置 其中切割结构穿过至少一部分易破壁。 外壁具有保持结构，其与活塞导向件接合以可释放地抵抗中空活塞在通气位置和密封位置与展开位置之间的滑动。 中空活塞可以具有外壁，并且所述外壁在腔室内具有面向可破坏壁的端部，其中切割端具有在所述切割结构中具有切割结构和间隙的第一边缘。

公开(公告)号：WO2016024127A1

公开(公告)日：2016-02-18

申请号：PCT/GB2015/052358

申请日：2015-08-14

Applicant: SENSEWHERE LIMITED

Inventor： ALSEHLY, Firas ,  SEVAK, Zankar Upendrakumar ,  ARSLAN, Tughrul Sati

IPC: G01S5/02

CPC classification number: G01S5/0252 ,  G01S5/0236 ,  H04W4/02

Abstract: In a mobile positioning system, mobile user devices carry out data validation on locally stored positioning data, regulating the positioning data provided to a positioning module and selectively requesting updated positioning data from a central database. A controller receives requests for updated positioning data and selectively responds with updates. The mobile user devices store observations data concerning measurements of signals from electromagnetic signal sources and transmit data about the locally stored observations data to the controller. The controller then selectively requests transmission of the locally stored observations data and the mobile user device determines when and whether to transmit that data. The amount of positioning data which must be transmitted to and from the mobile user device and the overall power consumption of the mobile user device is reduced. The decision as to what observations data to transmit to the controller is distributed between the mobile user device and the controller.

Abstract translation: 在移动定位系统中，移动用户设备对本地存储的定位数据进行数据验证，调节提供给定位模块的定位数据，并从中央数据库中选择性地请求更新的定位数据。 控制器接收更新的定位数据的请求，并选择性地响应更新。 移动用户设备存储关于来自电磁信号源的信号测量的观测数据，并将关于本地存储的观测数据的数据传送到控制器。 然后，控制器选择性地请求传输本地存储的观测数据，并且移动用户设备确定何时以及是否传送该数据。 必须向移动用户设备发送和从移动用户设备发送的定位数据量以及移动用户设备的总体功耗降低。 关于向控制器发送什么观测数据的决定分布在移动用户设备和控制器之间。

公开(公告)号：WO2015140551A1

公开(公告)日：2015-09-24

申请号：PCT/GB2015/050797

申请日：2015-03-18

Applicant: UNIVERSITY OF DUNDEE

Inventor： COLHOUN, Helen ,  LOOKER, Helen ,  MCKEIGUE, Paul ,  COLUMBO, Marco ,  DUNGER, David ,  DALTON, Neil ,  BROSNAN, Mary Julia ,  NOGOCEKE, Everson ,  AGAKOV, Felix ,  HESS, Sibylle

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/50 ,  G01N33/70 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G06F19/00 ,  G16H50/30

Abstract: Methods of predicting rapid decline in renal function in diabetes employing panels of biomarkers. The methods are useful for predicting risk of decline of renal function in individual subject and also for selecting subjects for clinical trials.

Abstract translation: 使用生物标志物组预测糖尿病肾功能快速下降的方法。 该方法可用于预测个体受试者肾功能下降的风险，也可用于选择临床试验对象。

公开(公告)号：WO2014162152A1

公开(公告)日：2014-10-09

申请号：PCT/GB2014/051068

申请日：2014-04-04

Applicant: O'CONNOR, Alexander, Ian, Nugent

Inventor： O'CONNOR, Alexander, Ian, Nugent

IPC: B63B35/79 ,  B63H16/08

CPC classification number: B63B35/79 ,  B63H16/18

Abstract: A board for water sports is provided that allows a user to more effectively propel the board through the water. The board comprises a first (2) and second (4) foot rest, a first (6) and second (8) arm support, wherein the first foot rest is coupled to the first arm support and the second foot rest is coupled to the second arm support such that movement of each foot rest produces a corresponding movement of the coupled arm support.

Abstract translation: 提供了一个水上运动的板子，允许用户更有效地推动板通过水。 所述板包括第一（2）和第二（4）脚踏板，第一（6）和第二臂支撑件（8），其中所述第一脚踏座联接到所述第一臂支撑件，并且所述第二脚踏板 第二臂支撑件，使得每个脚踏板的运动产生联接臂支撑件的相应运动。

公开(公告)号：WO2014087119A1

公开(公告)日：2014-06-12

申请号：PCT/GB2012/053061

申请日：2012-12-07

Applicant: ARTEMIS INTELLIGENT POWER LIMITED ,  DANFOSS POWER SOLUTIONS APS

Inventor： LAVENDER, Jack ,  VOLLER, Gordon

IPC: F04B1/04 ,  F03C1/04

CPC classification number: F04B1/0413 ,  F01B1/0658 ,  F03C1/0409 ,  F04B1/0426 ,  F04B1/053

Abstract: It is intended to provide a vehicle comprising a fluid working machine which can reduce wear of parts and be produced at low cost. The fluid working machine (11, 12) is provided with an eccentric cam (17), a piston 18A to 18F, a cylinder 19A to 19F, a drive rod 20A-20F having an engaging part (24) engaging with the piston and a contact part (25) contacting the eccentric cam (17), a holding member 34A to 34F surrounding the drive rod, a pressing member 40A to 40F for pressing up the holding member in a radially outward direction, and at least one holding ring (41) for holding the holding member from the outside.

Abstract translation: 本发明旨在提供一种包括流体加工机的车辆，其能够降低零件的磨损并以低成本生产。 流体加工机11,12设置有偏心凸轮17，活塞18A〜18F，气缸19A〜19F，具有与活塞接合的卡合部24的驱动杆20A〜20F， 与偏心凸轮（17）接触的接触部分（25），围绕驱动杆的保持构件34A至34F，用于沿径向向外的方向按压保持构件的按压构件40A至40F，以及至少一个保持环 ）用于从外部握持保持构件。

公开(公告)号：WO2014020341A1

公开(公告)日：2014-02-06

申请号：PCT/GB2013/052053

申请日：2013-07-31

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE

Inventor： JOVANOVIC, Aleksandar ,  KHAN, Faisel

IPC: G01N33/50

CPC classification number: C12Q1/6883 ,  C12N9/0008 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y102/01012 ,  G01N33/5064 ,  G01N2333/90203

Abstract: A method of determining the vascular endothelial function of a subject using GAPDH as a biomarker is presented, whereby the level of GAPDH mRNA and/or GAPDH protein in a sample obtained from a subject is measured and compared to a reference. A difference in the level of GAPDH mRNA and/or GAPDH protein between that measured for the sample and a reference may be indicative of impaired vascular endothelial function and therefore may indicate the onset of a condition related to impaired vascular endothelial function such as atherosclerosis.

Abstract translation: 提出了使用GAPDH作为生物标志物测定受试者的血管内皮功能的方法，由此测量从受试者获得的样品中GAPDH mRNA和/或GAPDH蛋白的水平并与参考比较。 在测量样品和参考值之间的GAPDH mRNA和/或GAPDH蛋白水平的差异可以指示血管内皮功能受损，因此可以指示与血管内皮功能受损有关的病症如动脉粥样硬化的发作。

公开(公告)号：WO2013072706A1

公开(公告)日：2013-05-23

申请号：PCT/GB2012/052858

申请日：2012-11-16

Applicant: AIRCRAFT MEDICAL LIMITED

Inventor： MCGRATH, Matthew John Ross ,  INGLIS, Peter Douglas Colin ,  RHODES, Thomas James

IPC: A61B1/267 ,  A61B1/00

CPC classification number: A61B1/267 ,  A61B1/00101 ,  A61B1/00147 ,  A61B90/90

Abstract: A laryngoscope body for use with laryngoscope blades is presented having an elongate handle and a blade retaining member configured to retain a blade such that the blade extends away from the elongate handle; wherein the blade retaining member is fixable at a plurality of positions to allow a blade to be retained on the blade retaining member at a plurality of - angles relative to the elongate handle. There is also disclosed a kit of parts comprising a laryngoscope body and a plurality of blades, as well as a method of use for the said laryngoscope body with a suitable laryngoscope blade.

Abstract translation: 提供了一种用于喉镜刀片的喉镜体，其具有细长手柄和构造成保持刀片的刀片保持构件，使得刀片远离细长手柄延伸; 其中所述刀片保持构件可固定在多个位置，以允许刀片相对于所述细长把手以多个角度保持在所述刀片保持构件上。 还公开了一种包括喉镜体和多个叶片的部件套件，以及用于具有合适的喉镜刀片的所述喉镜体的使用方法。

公开(公告)号：WO2012059744A1

公开(公告)日：2012-05-10

申请号：PCT/GB2011/052111

申请日：2011-10-28

Applicant: GAS SENSING SOLUTIONS LTD. ,  MACGREGOR, Calum John ,  GIBSON, Desmond Robert

Inventor： MACGREGOR, Calum John ,  GIBSON, Desmond Robert

IPC: G01N21/35 ,  G01N21/27

CPC classification number: G01N21/61 ,  G01J11/00 ,  G01N21/274 ,  G01N21/3504 ,  G01N2201/0696 ,  G01N2201/1211 ,  G01N2201/127

Abstract: An optical absorption gas sensor for detecting an analyte gas comprises a gas sample receiving chamber, at least one light emitting diode (LED) and a photodiode or other photosensor. A plurality of light pulses are generated by passing pulses of current through the at least one LED. The current through the at least one LED is measured a plurality of times during each pulse and taken into account when generating a compensated output signal. The transfer ratio between LED current and photodiode output signal is calculated a plurality of times during each pulse. An ADC measures the LED and photodiode currents alternately. The LED pulses are generated by inductor discharge flyback and the period of time for which current is supplied to the inductor prior to each pulse is selected so that the photodiode output current is at an optimal region within the input range of the ADC. At least the temperature of the at least one LED is measured and taken into account when generating the compensated output signal. Thus, rather than providing especially careful control of the LED pulses, the pulses are measured, enabling a simpler, lower power circuit which is tolerant of variations in temperature to be provided.

Abstract translation: 用于检测分析气体的光吸收气体传感器包括气体样品接收室，至少一个发光二极管（LED）和光电二极管或其它光电传感器。 通过使电流的脉冲通过至少一个LED来产生多个光脉冲。 通过至少一个LED的电流在每个脉冲期间被测量多次，并且在产生补偿的输出信号时被考虑。 在每个脉冲期间多次计算LED电流和光电二极管输出信号之间的传输比。 ADC交替测量LED和光电二极管电流。 LED脉冲由电感放电回扫产生，并且选择在每个脉冲之前向电感器提供电流的时间段，使得光电二极管输出电流处于ADC的输入范围内的最佳区域。 当产生补偿的输出信号时，至少测量并考虑至少一个LED的温度。 因此，不是特别仔细地控制LED脉冲，而是测量脉冲，使得能够提供容忍温度变化的更简单的较低功率电路。

公开(公告)号：WO2012059743A2

公开(公告)日：2012-05-10

申请号：PCT/GB2011/052110

申请日：2011-10-28

Applicant: GAS SENSING SOLUTIONS LTD. ,  MACGREGOR, Calum John ,  GIBSON, Desmond Robert

Inventor： MACGREGOR, Calum John ,  GIBSON, Desmond Robert

IPC: G01N21/35 ,  G01N21/27 ,  G01N33/00

CPC classification number: G01N21/27 ,  G01N21/274 ,  G01N21/3504 ,  G01N33/0006 ,  G01N2201/1211 ,  G01N2201/12723 ,  G01N2201/12753 ,  G01N2201/12792

Abstract: An optical absorption gas sensor has an LED light source and a photodiode light detector, a temperature measuring device for measuring the LED temperature and a temperature measuring device for measuring the photodiode temperature. The sensor is calibrated by measuring the response of photodiode current at zero analyte gas concentration and at a reference analyte gas concentration. From these measurement, calibration data taking into account the effect of photodiode temperature on the sensitivity of the photodiode and, independently, the effect of changes in the spectrum of light output by the LED on the light detected by the photodiode with LED temperature can be obtained. Calibration data is written to memory in the gas sensor and in operation of the gas sensor, the output is compensated for both LED and photodiode temperature. The LED and photodiode can therefore be relatively far apart and operate at significantly different temperatures allowing greater freedom of optical pathway design. There is also disclosed an elongate waveguide for an optical absorption gas sensor formed from two opposed compound parabolic collectors.

Abstract translation: 光吸收式气体传感器具有LED光源和光电二极管光检测器，用于测量LED温度的温度测量装置和用于测量光电二极管温度的温度测量装置。 通过测量零分析气体浓度和参考分析物气体浓度下的光电二极管电流的响应来校准传感器。 从这些测量中，考虑到光电二极管温度对光敏二极管的影响的影响的校准数据，并且独立地，可以获得由LED输出的光谱的变化对由LED温度的光电二极管检测到的光的影响 。 校准数据被写入气体传感器中的存储器，并且在气体传感器的操作中，输出被补偿LED和光电二极管的温度。 因此，LED和光电二极管可以相对较远并且在显着不同的温度下操作，从而允许更大的光路设计自由度。 还公开了一种用于由两个相对的复合抛物线收集器形成的光吸收气体传感器的细长波导。

公开(公告)号：WO2012032353A2

公开(公告)日：2012-03-15

申请号：PCT/GB2011/051686

申请日：2011-09-08

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH ,  WEBSTER, Eric Alexander Garner ,  HENDERSON, Robert Kerr

Inventor： WEBSTER, Eric Alexander Garner ,  HENDERSON, Robert Kerr

IPC: H01L31/042

CPC classification number: H01L31/107 ,  H01L27/1443 ,  H01L31/02327 ,  H01L31/02363 ,  H01L31/18 ,  H01L31/1804 ,  Y02E10/547 ,  Y02P70/521

Abstract: A single photon avalanche diode (400) is disclosed, for use in a CMOS integrated circuit, the single photon avalanche diode, SPAD, comprising: a deep n-well region (406) formed above a p-type substrate (402); an n-well region (408) formed above and in contact with the deep n-well region (406); a cathode contact (412) connected to the n-well region (408) via a heavily doped n-type implant (410); a lightly doped region (428) forming a guard ring around the n-well and deep n-well regions; a p-well region (416, 422) adjacent to the lightly doped region; and an anode contact (420, 426) connected to the p-well region via a heavily doped p-type implant (418, 424); the junction (414) between the bottom of the deep n-well region and the substrate forming a SPAD multiplication region when an appropriate bias voltage is applied between the anode and cathode and the guard ring breakdown voltage being controlled with appropriate control of the lateral doping concentration gradient such that the breakdown voltage is higher than that of the planar SPAD multiplication region.

Abstract translation: 公开了单光子雪崩二极管（400），用于CMOS集成电路中，单光子雪崩二极管SPAD包括：形成在p型衬底（402）上方的深n阱区（406）; 形成在深n阱区域（406）上方并与深n阱区域（406）接触的n-阱区域（408）。 通过重掺杂的n型植入物（410）连接到所述n阱区（408）的阴极接触（412）; 轻掺杂区域（428），围绕n阱和深n阱区域形成保护环; 邻近轻掺杂区的p阱区（416,422）; 以及经由重掺杂的p型植入物（418,424）连接到所述p阱区的阳极接触件（420,426）。 当在阳极和阴极之间施加适当的偏置电压时，在深n阱区域的底部和形成SPAD乘法区域的衬底之间的结（414），并且通过适当地控制横向掺杂来控制保护环击穿电压 浓度梯度使得击穿电压高于平面SPAD倍增区的击穿电压。